Inherited heart disease (cardiogenetics)
Genomics, Heart failure
Research aim
We aim to enhance patient and family lives impacted by inherited cardiomyopathies. Our efforts target gene and variant identification, disease mechanisms, factors influencing disease outcomes, therapy optimization, and exploration of novel therapies.
About us
The primary aim of the u-GENE-CARE (Utrecht genetic cardiomyopathy) research group is to enhance the quality of life for patients and families with inherited cardiac diseases, especially cardiomyopathies. Our approach involves a comprehensive examination of all aspects of disease, including pathophysiologic mechanisms, genetic underpinnings, clinical manifestations, and therapeutic advancements. Utilizing diverse model systems such as natural occurring animal models and induced pluripotent cardiac stem cells (iPSc), we delve into aspects of disease pathology to gain deeper insights and drive innovation in treatment strategies. The main strength of u-GENE-CARE lies in our team’s expertise across various disciplines, enabling us to conduct research seamlessly from laboratory to clinical application. This significantly expedites the translation of research findings into clinical practice, thereby enhancing patient care. Our PIs maintain robust partnerships with (inter)national research groups, facilitating the exchange of knowledge and resources. Within the Netherlands we work closely with all partners of the National Working Group of Cardiogenetics, leveraging collective expertise for greater impact.
Furthermore, our clinical team members hold accreditation with the National Centres of Expertise (NFU) and the European Reference Network (GUARD HEART) for several cardiogenetic disorders, underscoring our commitment to excellence in clinical care and research advancement.