Profile photo Linda van Laake

Linda van Laake

Associate Professor

Biography

Linda W. Van Laake, MD, PhD obtained her medical degree at Maastricht University and her PhD (title: Cardiac Recovery by Stem and Progenitor Cells) at Utrecht University, after which she continued her scientific career as a postdoctoral researcher at the Gladstone Institutes, University of California, San Francisco (USA). In 2011 she became Assistant Professor at the Department of Cardiology of the University Medical Center Utrecht and the Hubrecht Institute Utrecht, the Netherlands. In addition, she works as a clinical cardiologist specialized in heart failure.

Dr. Van Laake’s team explores novel approaches to regenerate the heart using stem- and progenitor cells. Many cardiovascular diseases, such as heart failure and myocardial infarction, are associated with loss of functional cardiomyocytes (heart muscle cells). A focus on the understanding of fundamental cardiac developmental – and repair processes will promote the recapitulation of cardiac differentiation in vitro. Currently, the team is investigating the influence of circadian or “day-night” rhythms on cardiac development and regeneration.

Combing a variety of novel approaches together with a greater understanding of how heart development and repair work, Dr. Van Laake and her team strive to create better personalized heart failure therapies.

 

Research groups

Inherited heart disease (cardiogenetics)

Research aim

We aim to enhance patient and family lives impacted by inherited cardiomyopathies. Our efforts target gene and variant identification, disease mechanisms, factors influencing disease outcomes, therapy optimization, and exploration of novel therapies.

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Recent publications

Impairments identified by comprehensive geriatric assessment in potential candidates for left ventricular assist device and heart transplantation Lauren Dautzenberg, Linda W. van Laake, Renee C.M.A. Raijman, Geert J. Lefeber, Wilma Knol, Marish I.F. Oerlemans, Faiz Z. Ramjankhan, Susan A. Braithwaite, Mieke D.J. Nagtegaal, Marielle H. Emmelot-Vonk, Huiberdina L. Koek
IJC Heart and Vasculature, 2024, vol. 50
ECPELLA as a bridge-to-decision in refractory cardiogenic shock Jan Willem Balder, Mariusz K. Szymanski, Linda W. van Laake, Pim van der Harst, Christiaan L. Meuwese, Faiz Z. Ramjankhan, Manon G. van der Meer, Jeannine A.J.M. Hermens, Michiel Voskuil, Eric E.C. de Waal, Dirk W. Donker, Marish I.F.J. Oerlemans, Adriaan O. Kraaijeveld
Netherlands Heart Journal, 2024, vol. 32, p.245-253
Cardiac magnetic resonance in advanced heart failure Francesca Coraducci, Giulia De Zan, Damiano Fedele, Pietro Costantini, Andrea Igoren Guaricci, Anna Giulia Pavon, Arco Teske, Maarten Jan Cramer, Lysette Broekhuizen, Dirk Van Osch, Ibrahim Danad, Birgitta Velthuis, Dominika Suchá, Ivo van der Bilt, Carmine Pizzi, Antonio Dello Russo, Marish Oerlemans, Linda W van Laake, Pim van der Harst, Marco Guglielmo
Echocardiography, 2024, vol. 41, p.1-13
Survival after HeartMate 3 left ventricular assist device implantation Lieke Numan, Rene Schramm, Marish I F J Oerlemans, Niels P van der Kaaij, Emmeke Aarts, Faiz Z Ramjankhan, Anne-Marie Oppelaar, Michiel Morshuis, Sabina P W Guenther, Daniel Zimpfer, Julia Riebandt, Dominik Wiedemann, Folkert W Asselbergs, Linda W Van Laake
ESC heart failure, 2023, vol. 10, p.2754-2756
Developing a personalized remote patient monitoring algorithm Mehran Moazeni, Lieke Numan, Maaike Brons, Jaco Houtgraaf, Frans H Rutten, Daniel L Oberski, Linda W van Laake, Folkert W Asselbergs, Emmeke Aarts
European Heart Journal - Digital Health, 2023, vol. 4, p.455-463
Identifying patients at risk Lieke Numan, Daniel Zimpfer, Osnat Itzhaki Ben Zadok, Emmeke Aarts, Michiel Morshuis, Sabina P W Guenther, Julia Riebandt, Dominik Wiedemann, Faiz Z Ramjankhan, Anne-Marie Oppelaar, Tuvia Ben-Gal, Binyamin Ben-Avraham, Folkert W Asselbergs, Rene Schramm, Linda W Van Laake
ESC heart failure, 2023, vol. 10, p.1656-1665