Profile photo Magdaléna Harakalová

Magdaléna Harakalová

Assistant Professor

Biography

I am an Assistant Professor at the Department of Cardiology and the Regenerative Medicine Utrecht (RMU) center at UMCU. As a principal investigator, I am leading an independent research line that is based on a clear need from clinics: the identification of molecular mechanisms in carriers of genetic mutations who are at risk of developing genetic cardiomyopathies. My overarching research question is: Why is DNA not the heart’s destiny? - I study the chronological effects of a DNA mutation on the level of DNA/chromatin/RNA/protein but also cellular organelles, whole cells, tissue and the human organism. I aim to redefine cardiomyopathies on a personalized level and design diagnostic, preventive, and treatment strategies with the ultimate goal to timely predict and eradicate them. I use human cardiac tissue and patient-derived human iPSC-cardiomyocyte (hiPSC-CMs) models to investigate cardiomyopathy heterogeneity through next-generation sequencing-based -omics techniques, bioinformatics, high-resolution imaging, and functional studies. I have a medical background but I decided to work as a full-time scientist because I felt that progress made in fundamental research does not reach clinics fast enough.

Research groups

Inherited heart disease (cardiogenetics)

Research aim

We aim to enhance patient and family lives impacted by inherited cardiomyopathies. Our efforts target gene and variant identification, disease mechanisms, factors influencing disease outcomes, therapy optimization, and exploration of novel therapies.

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Recent publications

Locational memory of macrovessel vascular cells is transcriptionally imprinted Talitha C F Spanjersberg, Loes A Oosterhoff, Hedwig S Kruitwagen, Noortje A M van den Dungen, Johannes C M Vernooij, Folkert W Asselbergs, Michal Mokry, Bart Spee, Magdalena Harakalova, Frank G van Steenbeek
Scientific Reports, 2023, vol. 13
Identification of novel genetic risk factors of dilated cardiomyopathy Julia E Niskanen, Åsa Ohlsson, Ingrid Ljungvall, Michaela Drögemüller, Robert F Ernst, Dennis Dooijes, Hanneke W M van Deutekom, J Peter van Tintelen, Christian J B Snijders Blok, Marion van Vugt, Jessica van Setten, Folkert W Asselbergs, Aleksandra Domanjko Petrič, Milla Salonen, Sruthi Hundi, Matthias Hörtenhuber, Juha Kere, W Glen Pyle, Jonas Donner, Alex V Postma, Tosso Leeb, Göran Andersson, Marjo K Hytönen, Jens Häggström, Maria Wiberg, Jana Friederich, Jenny Eberhard, Magdalena Harakalova, Frank G van Steenbeek, Gerhard Wess, Hannes Lohi,
Genome Medicine, 2023, vol. 15
A Systematic Analysis of the Clinical Outcome Associated with Multiple Reclassified Desmosomal Gene Variants in Arrhythmogenic Right Ventricular Cardiomyopathy Patients Emilia Nagyova, Edgar T Hoorntje, Wouter P Te Rijdt, Laurens P Bosman, Petros Syrris, Alexandros Protonotarios, Perry M Elliott, Adalena Tsatsopoulou, Luisa Mestroni, Matthew R G Taylor, Gianfranco Sinagra, Marco Merlo, Yuko Wada, Minoru Horie, Jens Mogensen, Alex H Christensen, Brenda Gerull, Lei Song, Yan Yao, Siyang Fan, Ardan M Saguner, Firat Duru, Juha W Koskenvuo, Tania Cruz Marino, Crystal Tichnell, Daniel P Judge, Dennis Dooijes, Ronald H Lekanne Deprez, Cristina Basso, Kalliopi Pilichou, Barbara Bauce, Arthur A M Wilde, Philippe Charron, Véronique Fressart, Jeroen F van der Heijden, Maarten P van den Berg, Folkert W Asselbergs, Cynthia A James, Jan D H Jongbloed, Magdalena Harakalova, J Peter van Tintelen
Journal of Cardiovascular Translational Research, 2023, vol. 16, p.1276-1286
Generation and characterization of novel human induced pluripotent stem cell (iPSC) lines originating from five asymptomatic individuals carrying the PLN-R14del pathogenic variant and a non-carrier relative Valentina Balducci, Francesco Scardigli, Magdalena Harakalova, J. Peter. van Tintelen, Pieter A. Doevendans, Kevin D. Costa, Irene C. Turnbull, Joost P. G. Sluijter, Francesca Stillitano
Stem Cell Research, 2023, vol. 72
Sarcomere Disassembly and Transfection Efficiency in Proliferating Human iPSC-Derived Cardiomyocytes Qianliang Yuan, Renee G.C. Maas, Ellen C.J. Brouwer, Jiayi Pei, Christian Snijders Blok, Marko A. Popovic, Nanne J. Paauw, Niels Bovenschen, Jesper Hjortnaes, Magdalena Harakalova, Pieter A. Doevendans, Joost P.G. Sluijter, Jolanda van der Velden, Jan W. Buikema
Journal of Cardiovascular Development and Disease, 2022, vol. 9, p.1-13
Genetic Basis of Dilated Cardiomyopathy in Dogs and Its Potential as a Bidirectional Model Karen R Gaar-Humphreys, Talitha C F Spanjersberg, Giorgia Santarelli, Guy C M Grinwis, Viktor Szatmári, Bernard A J Roelen, Aryan Vink, J Peter van Tintelen, Folkert W Asselbergs, Hille Fieten, Magdalena Harakalova, Frank G van Steenbeek
Animals : an open access journal from MDPI, 2022, vol. 12, p.1-18