Transplantation
adaptive alloimmunity, innate immunity, viral and bacterial infections
Research aim
We aim to understand how infection and immunity impact transplantation. By uncovering these mechanisms, we aim to improve patient care, reduce rejection and complications, and enhance success rates, benefiting society with better health outcomes.
About us
The Transplantation Team tackles the complex challenges related to transplantation, infection, and immunity. Transplantation offers life-saving treatments, yet risks such as infections, rejection, and Graft-versus-Host disease remain significant hurdles. We aim to unravel the intricate interactions between infections, the immune system, and transplanted organs to enhance patient outcomes and advance medical science.
Our research bridges basic science and clinical practice. By elucidating mechanisms underlying transplant-related infections and immune responses, we strive to develop novel therapeutic strategies and diagnostic tools. Our ultimate goal is to prolong graft survival, reduce infectious complications, and improve the quality of life for transplant recipients.
We adopt a multidisciplinary approach, integrating expertise from immunology, microbiology, transplantation medicine, and bioinformatics, while connecting to Regenerative Medicine, Circulatory Health, and Cancer. Our collaborative efforts, involving experimental, computational, and clinical methodologies, enable us to explore complex biological phenomena comprehensively.
We maintain strong interactions with national and international bodies like Eurotransplant, the National Committee for Kidney Transplantation (LONT), and the Dutch Organ Transplant Registry. Additionally, we engage with companies and regulatory agencies to translate our findings into clinical applications and influence healthcare policies.