Profile photo Eric Spierings

Eric Spierings

Associate Professor

Strategic program(s):

Biography

Dr. Spierings received his PhD degree as immunologist at the Leiden University Medical Center, The Netherlands and was subsequently recognized as SMBWO Immunologist by the Dutch Society for Immunology. His postdoctoral training was performed on minor H antigens in organ- and stem-cell transplantation in the laboratory of Prof. Dr. Els Goulmy, Leiden, The Netherlands. In 2008, he was appointed as lab director of the HLA laboratory of the University Medical Centre Utrecht, The Netherlands. In that position, he combines diagnostic histocompatibility testing with research. His current scientific interest focusses on the role of indirect recognition of mismatched HLA in transplantation and on post-transplant immunomonitoring via Next Generation Sequencing of T- and B-cell receptors and immunoglobulins.

Research groups

Transplantation

Research aim

We aim to understand how infection and immunity impact transplantation. By uncovering these mechanisms, we aim to improve patient care, reduce rejection and complications, and enhance success rates, benefiting society with better health outcomes.

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Recent publications

Specific Immune Defence Eric Spierings
2025, p.39-67
Maternal-Foetal HLA-DQB1 Incompatibility Is Associated With Pregnancy-Induced Hypertensive Disorders in a Genetically Isolated Population Liseanne J Van't Hof, Marie-Louise P van der Hoorn, Selena Migdis, Geert W Haasnoot, Emma T M Peereboom, Eric Spierings, Pieter J E van der Linden, Jacqueline D H Anholts, Heleen de Vreede, Winnie Ottenhof, Dave L Roelen, Michael Eikmans, Inge B Mathijssen, Lisa E E L O Lashley
HLA, 2025, vol. 106
Molecular disparity of HY antigen affects chronic graft-versus-host disease and relapse in female-to-male stem cell transplants Rima M Saliba, Matthias Niemann, Samer A Srour, Uri Greenbaum, Kamal K Alzahrani, Yudith Carmazzi, Gabriela Rondon, Katayoun Rezvani, May Daher, Dan Li, Qing Ma, Mark R Tanner, Kai Cao, Elizabeth J Shpall, Richard E Champlin, Eric Spierings, Jun Zou
Transplantation and cellular therapy, 2025, vol. 31, p.903-915
Swine Xenografts Share Few Predicted Indirectly Recognisable SLA-Derived Epitopes With HLA-Derived Epitopes From Human Kidney Grafts Benedict M Matern, Eric Spierings, Emma Peereboom, Matt Tector, Joseph Tector, Massimo Mangiola, Robert A Montgomery, Matthias Niemann
HLA, 2025, vol. 105
The Registry of Unmet Need Martin Maiers, Valerie Greco-Stewart, Abeer Madbouly, James Robinson, Hans-Peter Eberhard, Jürgen Sauter, Yoram Louzoun, Sapir Israeli, Yung-Tsi Bolon, Julia Pingel, Alexander H Schmidt, Eric Spierings, Christina Leonhard-Melief, Lydia Foeken, Martine Schuit, Alicia Venter, Steven G E Marsh
HLA, 2025, vol. 105
Indirect presentation of mismatched human leukocyte antigen-B associates with outcomes of cord blood transplantation Takeshi Sugio, Kohta Miyawaki, Naoyuki Uchida, Matthias Niemann, Eric Spierings, Kyohei Mori, Yuju Ohno, Tetsuya Eto, Yasuo Mori, Goichi Yoshimoto, Yoshikane Kikushige, Yuya Kunisaki, Shinichi Mizuno, Koji Nagafuji, Hiromi Iwasaki, Tomohiko Kamimura, Ryosuke Ogawa, Toshihiro Miyamoto, Shuichi Taniguchi, Koichi Akashi, Koji Kato
British Journal of Haematology, 2025, vol. 206, p.1406-1417

Fellowships & Awards

  • 1997: KNAW van Walree Grant
  • 2002: Best Abstract Award – 13th International Histocompatibility Workshop Conference 
  • 2004: Special Fellow – Leukemia and Lymphoma Society 
  • 2007: Best Abstract Award – European Federation for Immunogenetics Conference
  • 2009: Best Abstract Award – European Federation for Immunogenetics Conference
  • 2013: Ureka Mega Challenge Award for Innovation – UMC Utrecht
  • 2016: Novartis Award for best scientific publication – Dutch Transplantation Society
  • 2017: Medical Immunology Science Award – Dutch Society for Immunology

External positions

Scientific Advisory Board of the Center for Research in Transplantation and Translational Immunology - Evaluatie van het basale en translationele onderzoeksprogramma - CR2TI, onderdeel Université Nantes en INSERM geaffilieerd

Lid Science & Technology Initiatives Committee (STIC) - Liaison namens EFI binnen deze ASHI commissie - American Society of Histocompatibility and Immunogenetics

Member of the Scientific Committee - Member of the Scientific Committee - European Federation for Immunogenetics

Co-president - HLA, transplantation, and immunogenetics - International HLA & Immunogenetics Workshop Council

Contract Research - Onderzoek naar T cel en B cel epitopen en verfijnen van bestaande algoritmes - PIRCHE AG

Medisch Immunoloog Kenniscentrum MATCHIS. Consultverlening in het kader van stamceltransplantatie. - Histocompatibiliteit in stamceltransplantatie. Complementair en niet competerend. - Stichting MATCHIS

Member of the Editorial Board - Member of the Editorial Board - HLA Immune Response Genetics

Chair of the IT and Bioinformatics Committee - HLA and automation - European Federation for Immunogenetics

Chair of the Bioinformatics and IT Committee - Chair of the Bioinformatics and IT Committee - European Federation for Immunogenetics

Chair and Treasurer - HLA, transplantation, and Immunogenetics - 18th International HLA&Immunogenetics Workshop Foundation

Associate Editor - Associate Editor - Frontiers in Immunology

Member of the Editorial Board - Member of the Editorial Board - Cellular Immunology

Contract Research and advisory function - HLA matching at the epitope level - PIRCHE AG