T:B cell interactions in human lymph nodes
Immune development, lymphoid structure, Translational Immunology
Research aim
Our mission is to investigate the complex interactions between T and B cells within human lymph nodes, aiming to drive meaningful clinical advancements.
About us
The human lymph node serves as a critical hub for immune cell coordination, crucial for initiating and regulating adaptive immune responses. While T and B cells are central to this process, their interactions within lymph nodes are not fully understood. Our research group aims to delve into the intricate interplay between T and B cells within human lymph nodes, shedding light on their collaboration, communication, and mutual influence during immune responses. Through advanced imaging techniques and immune and molecular profiling of lymph nodes across various conditions and ages, we strive to unveil novel insights into the spatial organization, molecular signalling, and functional outcomes of T and B cell interactions within the lymph node microenvironment, both in health and disease. Additionally, we develop and refine lymphoid models, such as tonsil organoids and synthetic 3D models, to better mimic in vivo complexity, enabling the study of immune responses, disease modelling, and the exploration of new interventions. The outcomes of our research will advance our understanding of immune cell dynamics, guide the development of targeted immunotherapies, and ultimately lead to improved treatments for immune-related disorders and diseases.