Systems biology of gene regulation

Research aim

We aim to uncover the principles by which genome organization and epigenetic dynamics control gene regulation, and to understand how disruption of these systems reshapes cellular identity in disease.

About us

Gene regulation is not encoded in DNA sequence alone. It emerges from dynamic interactions between chromatin states, three-dimensional genome organization, and transcriptional networks. When these systems shift, cells change identity; when they destabilize, disease can arise.

Our group uncovers the principles governing these regulatory systems. We combine experimental innovation in single-cell assays with quantitative and computational approaches to measure genetic, epigenetic, structural, and transcriptional layers within individual cells. This integrated strategy moves beyond static maps toward mechanistic and predictive understanding.

We focus on regulatory transitions: how epigenetic plasticity enables state changes, how non-canonical chromatin organization forms, and how structural variation reshapes regulatory landscapes. Rather than studying these layers in isolation, we examine how they interact to produce stable—or unstable—gene regulatory systems.