Glia biology of brain diseases
brain organoids, iPSCs, neurodegenerative disease
Research aim
Glia play a crucial role in dementia, stroke, neurodevelopmental disorders, and brain tumors. We aim to understand how glia are mechanistically involved and use this knowledge to contribute to glia-targeted therapies for these brain disorders.
About us
Glia are the brain’s most predominant cell type. For years these cells were dismissed as mere helpers for neurons, with little regard for their full impact in sickness and health.
Recent findings indicate a much larger role for glia than anticipated. Astrocytes exhibit stem-cell like properties, suggesting regenerative potential. Moveover, glia appear to be implicated in neurodegenerative diseases like Alzheimer’s Disease (AD) via an upregulated state called gliosis.
Our research group aims to understand the mechanisms by which glia are involved in neuro-development and -degeneration. We investigate this in AD, Alexander Disease, glioma and disorders involving blood-brain barrier (BBB) leakage. Several questions guide our research: How do glia behave and communicate with other cells at different stages of pathogenesis? How might such dynamics affect disease phenotype?
We employ innovative cell culture systems such as patient-derived induced pluripotent stem cells (iPSCs) and brain organoids. Our cerebral organoids are the first in the world to describe innate microglia development. A novel in vitro BBB model is also in development. Finally, we trigger anti-tumor responses in glioma models.
We aim to better understand neurological disorders, thereby accelerating the development of therapeutics for millions of affected people.
We train biomedical students and partner with leading global research groups and patient organizations, working with strong collaborative spirit.