Profile photo Elly Hol

Elly Hol

Full Professor

Strategic program(s):


Elly Hol is Vice-Dean of Research of the University Medical Center Utrecht, professor of “Glia biology of brain diseases” at the Utrecht University, a member of the Royal Netherlands Academy of Arts and Sciences (KNAW), and a member of the Academia Europaea. She is head of the department of Translational Neuroscience at the University Medical Center Utrecht Brain Center. Her research is focused on the role of glial cells in brain diseases. The overall aim is to elucidate the molecular and functional changes in glia that contribute to the pathogenesis of neurological and psychiatric diseases. Her work is translational and includes studies on glial cells in human post-mortem brain tissue, in human cell models, and in mouse models for brain diseases. Elly was trained as a medical biologist with a specialization in molecular neurobiology. After her PhD in Utrecht, she obtained a Max-Planck Fellowship to work at the Max-Planck-Institute for Psychiatry in Martinsried. In 1997, she started as a post-doc at the Netherlands Institute for Neuroscience in Amsterdam, and between 2003 and 2013 she headed the group “Astrocyte Biology & Neurodegeneration”. She was appointed professor of "Biology of glia and neural stem cells” at the University of Amsterdam in 2012. As of 2013 she works as a principal investigator at the department of translational neuroscience, UMC Utrecht Brain Center. She is in the editorial board of Glia and she is a board member of the Medical, Biomedical, and Health Sciences Domain of the KNAW.

Research groups

Glia biology of brain diseases

Research aim

Glia play a crucial role in dementia, stroke, neurodevelopmental disorders, and brain tumors. We aim to understand how glia are mechanistically involved and use this knowledge to contribute to glia-targeted therapies for these brain disorders.

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Recent publications

Early amyloid-induced changes in microglia gene expression in male APP/PS1 mice Takuya Oshima, Mandy S J Kater, Christiaan F M Huffels, Evelyn M Wesseling, Jinte Middeldorp, Elly M Hol, Mark H G Verheijen, August B Smit, Erik W G M Boddeke, Bart J L Eggen
Journal of Neuroscience Research, 2024, vol. 102
GFAP-isoforms in the nervous system Alexandra J E M de Reus, Onur Basak, Werner Dykstra, Jessy V van Asperen, Emma J van Bodegraven, Elly M Hol
Current Opinion in Cell Biology, 2024, vol. 87
Progesterone receptor distribution in the human hypothalamus and its association with suicide Lin Zhang, Ronald W H Verwer, Joop van Heerikhuize, Paul J Lucassen, Peter W Nathanielsz, Elly M Hol, Eleonora Aronica, Waljit S Dhillo, Gerben Meynen, Dick F Swaab
Acta neuropathologica communications, 2024, vol. 12
Corrigendum Zuzana Matusova, Elly M Hol, Milos Pekny, Mikael Kubista, Lukas Valihrach
Frontiers in Cellular Neuroscience, 2023, vol. 17, p.1212975
Reactive astrogliosis in the era of single-cell transcriptomics Zuzana Matusova, Elly M. Hol, Milos Pekny, Mikael Kubista, Lukas Valihrach
Frontiers in Cellular Neuroscience, 2023, vol. 17
Limited Effects of Class II Transactivator-Based Immunotherapy in Murine and Human Glioblastoma A Katherine Tan, Aurelie Henry, Nicolas Goffart, Sofie van Logtestijn, Vincent Bours, Elly M Hol, Pierre A Robe
Cancers, 2023, vol. 16

External positions

Member Scientific Advisory Board, Alzheimer Nederland

Chair Scientific Advisory Board, Parkinson Nederland

Board member, Stichting vrienden van het Herseninstituut

Chair Scientific Advisory Board, Alzheimer Nederland

Member scientific advisory board EndParalysis Foundation, EndParalysis foundation

Member editorial board, Glia (scientific journal)

Member scientific advisory board, Hersenstichting

Special professor of Biology of glia and neural stem cells, University of Amsterdam