Profile photo Elly Hol

Elly Hol

Full Professor

Strategic program(s):

Biography

Elly Hol is Vice-Dean of Research of the University Medical Center Utrecht, professor of “Glia biology of brain diseases” at the Utrecht University, a member of the Royal Netherlands Academy of Arts and Sciences (KNAW), and a member of the Academia Europaea. She is head of the department of Translational Neuroscience at the University Medical Center Utrecht Brain Center. Her research is focused on the role of glial cells in brain diseases. The overall aim is to elucidate the molecular and functional changes in glia that contribute to the pathogenesis of neurological and psychiatric diseases. Her work is translational and includes studies on glial cells in human post-mortem brain tissue, in human cell models, and in mouse models for brain diseases. Elly was trained as a medical biologist with a specialization in molecular neurobiology. After her PhD in Utrecht, she obtained a Max-Planck Fellowship to work at the Max-Planck-Institute for Psychiatry in Martinsried. In 1997, she started as a post-doc at the Netherlands Institute for Neuroscience in Amsterdam, and between 2003 and 2013 she headed the group “Astrocyte Biology & Neurodegeneration”. She was appointed professor of "Biology of glia and neural stem cells” at the University of Amsterdam in 2012. As of 2013 she works as a principal investigator at the department of translational neuroscience, UMC Utrecht Brain Center. She is in the editorial board of Glia and she is a board member of the Medical, Biomedical, and Health Sciences Domain of the KNAW.

Research groups

Glia biology of brain diseases

Research aim

Glia play a crucial role in dementia, stroke, neurodevelopmental disorders, and brain tumors. We aim to understand how glia are mechanistically involved and use this knowledge to contribute to glia-targeted therapies for these brain disorders.

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Recent publications

Molecular pathology, developmental changes and synaptic dysfunction in (pre-) symptomatic human C9ORF72-ALS/FTD cerebral organoids Astrid T van der Geest, Channa E Jakobs, Tijana Ljubikj, Christiaan F M Huffels, Marta Cañizares Luna, Renata Vieira de Sá, Youri Adolfs, Marina de Wit, Daan H Rutten, Marthe Kaal, Maria M Zwartkruis, Mireia Carcolé, Ewout J N Groen, Elly M Hol, Onur Basak, Adrian M Isaacs, Henk-Jan Westeneng, Leonard H van den Berg, Jan H Veldink, Domino K Schlegel, R Jeroen Pasterkamp
Acta neuropathologica communications, 2024, vol. 12
Emerging Models to Study Human Microglia In vitro Henna Jäntti, Lois Kistemaker, Alice Buonfiglioli, Lot D De Witte, Tarja Malm, Elly M Hol
Advances in neurobiology, 2024, vol. 37, p.545-568
Early amyloid-induced changes in microglia gene expression in male APP/PS1 mice Takuya Oshima, Mandy S J Kater, Christiaan F M Huffels, Evelyn M Wesseling, Jinte Middeldorp, Elly M Hol, Mark H G Verheijen, August B Smit, Erik W G M Boddeke, Bart J L Eggen
Journal of Neuroscience Research, 2024, vol. 102
GFAP-isoforms in the nervous system Alexandra J E M de Reus, Onur Basak, Werner Dykstra, Jessy V van Asperen, Emma J van Bodegraven, Elly M Hol
Current Opinion in Cell Biology, 2024, vol. 87
Progesterone receptor distribution in the human hypothalamus and its association with suicide Lin Zhang, Ronald W H Verwer, Joop van Heerikhuize, Paul J Lucassen, Peter W Nathanielsz, Elly M Hol, Eleonora Aronica, Waljit S Dhillo, Gerben Meynen, Dick F Swaab
Acta neuropathologica communications, 2024, vol. 12
Corrigendum Zuzana Matusova, Elly M Hol, Milos Pekny, Mikael Kubista, Lukas Valihrach
Frontiers in Cellular Neuroscience, 2023, vol. 17, p.1212975

External positions

Bestuurslid/domeinvoorzitter Medische, Medisch-Biologische en Gezondheidswetenschappen - Vakinhoudelijke discussies en advies over biomedische zaken aan KNAW bestuur. - KNAW

Lid editorial board - Ik review wetenschappelijke artikelen op mijn vakgebied. - Tijdschrift Glia van de uitgever Wiley