Advanced microscopy and organelle dynamics
Lysosomes, organelles, electron microscopy, cell biology, cancer, neurodegenerative diseases
Research aim
We aim to comprehend the complex process of lysosome biogenesis in health and disease. Advancing our understanding holds promise for novel treatments of cancer and neurodegenerative diseases
About us
The Klumperman lab is dedicated to exploring membrane trafficking in health and disease, with a specific focus on lysosomes. Lysosomes are essential organelles that regulate cellular metabolism as well as some to the major signaling pathways in the cell, making them a key target for our research. Given the involvement of lysosomes in diseases like cancer and neurodegenerative disorders, our research is crucial for understanding and potentially treating these conditions.
Our unique approach involves visualizing lysosomes using specialized electron microscopy (EM) techniques. Judith Klumperman is an expert in EM, and the lab utilizes a unique combination of EM, molecular, and biochemical methods to unravel the intricate morpho-molecular organization within cells. Our expertise in immuno-EM and correlative microscopy (CLEM) allows us to directly correlate information from live cells to EM images, enhancing our understanding of cellular processes.
Currently, our research topics span endo-lysosomal biology, membrane trafficking, neuronal cell biology, autophagy, cancer cell biology, and correlative light and electron microscopy. Through our interdisciplinary approach and collaborative efforts, we aim to make significant contributions to both basic science and clinical applications in understanding and treating diseases.