Full Professor
Strategic program(s):
Biography
2008 finished fellowship Neonatal Neurology (Prof dr. Linda de Vries)
2006 Pediatrician- Neonatologist (prof. dr. Frank van Bel)
1999 PhD, Leiden University, the Netherlands (prof. dr. Margot van de Bor)
1996 Bachelor of Medicine, Leiden University, the Netherlands
Her research focuses on neonatal neuro-imaging. These techniques appear to give the opportunity to detect subtle differences, which are helpful in predicting neurodevelopmental outcome and evaluating of neuroprotective/neuroregenerative strategies to reduce brain injury, which is the other part of her research.
Research aim
To improve long term cardiovascular and neurodevelopmental outcome in patients with severe congenital heart disease.Research aim
We use longitudinal fetal and neonatal neuroimaging and neuromonitoring to study brain development and function, model brain diseases, and improve long term outcome in high-risk infants.Research aim
Our mission is to unravel the impact of early life adversity, such as perinatal asphyxia and stroke, preterm birth and early life stress on brain development and to design strategies to improve outcome of affected infants, shaping a better future.Research aim
Our mission is to unravel the impact of neonatal surgery, as well for congenital heart defects as non-cardiac anomalies on brain injury, development and long-term impairments to develop strategies to improve long-term outcome shaping a better future.1991 Leids Universitair Fonds: International Foundation for Student Research Projects: ‘Cardiac and Cerebral Doppler-sonography in Neonates’. University of California Los Angeles, Verenigde Staten (€20K)
2005 NSCK reward: Registry ‘Severe Hyperbilirubinemia in Neonates in the Netherlands.’ (NSCK, surveillance) (€10k)
2006 “Ter Meulen Fonds”, Royal Netherlands Academy of Arts and Sciences, The Netherlands, Clinical Research Fellowship. Supervisor: Prof. P.S. Hüppi, University of Geneva, Switzerland (€50k)
2006 International Pediatric Research Foundation (IPRF): exchange program Young Investigator Fellowship of the ESPR, for Clinical Research fellowship Geneve, Prof. P.S. Hüppi, University Geneva, Switzerland (€20k)
2009 The Netherlands Organisation for Scientific Research (NWO): program ‘early evaluation of medical innovation’: ‘Perinatal allopurinol trial for reduction of birth asphyxia induced brain damage’. Co-PI with Obstetrician: Dr. J.B. Derks (PhD: Joepe Kaandorp) (€150k +€50K UMCU)
2009 Alexandre Suerman Stipendium: ‘Reference ranges for the lateral cerebral ventricles of newborn infants’ (PhD: Margaretha Brouwer) (€75k +€50k UMCU)
2009 Catherijne Foundation: MRI of preterm infants: prediction of neurodevelopmental outcome (€200k)
2010 Univeristy Medical Center Utrecht / Wilhelmina Children’s Hospital Foundation: ‘Maturation dependent vulnerability of the Brain and Outcome of Preterm Infants assessed by MRI’ (PhD: Karina Kersbergen) (€150k+€50k UMC)
2011 International Foundation initiated by University Medical Centre Utrecht ‘MRI-biomarkers of Outcome and Perinatal Brain Injury in Neonates with Congenital Heart Disease’ (€50k)
2013 Dutch Ministry of Economic Affairs, the Province and Municipality of Utrecht, Utrecht University and the University Medical Center Utrecht: ‘The Nutri-brain project: a randomised, double-blind, controlled trial to evaluate the effects of a nutritional supplement on brain integrity in preterm infants’. (€2.5m)
2016 Nutricia research: fetal and neonatal MRI in youth cohort utrecht. 200.000 euro. Elise Turk
2018 Crucial trial: : CeRebrUm and CardIac protection with ALlopurinol in neonates with congenital heart disease requiring neonatal cardiac surgery.zonMW 80-84800-98-42022 (1.6 mljn). National RCT. Prinicipal investigator.
2008-2010 European project Framework VI: ‘NEOBRAIN Neonatal estimation of brain damage risk and identification of neuroprotectants’ LSHM-CT-2006-036534, contract Nr 036534. Member of the MRI workpackage. (€2.3m)
2009 Ministero della Salute – Direzione Generale della Ricerca Scientifica e Tecnologica. ‘Early identification of newborns at high risk of brain injury through a valida- ted biomarkers profile and specific neuro-imaging patterns. A follow up study of clinical and neurodevelopmental outcome in a large cohort study’. (PI Prof G. Buonocore, University Siena.) Co-applicant, co-supervised 3 PhD students. (€800k)
2011 European study: ‘SafeBoosC: Safeguarding the brain of our smallest children: randomised, blinded, multinational (10 countries), phase II feasibility clinical trial on near-infrared spectroscopy monitoring combined with defined treatment guidelines versus standard monitoring and treatment as usual in premature infantsconsortium’. Neuro-imaging work package leader. (€1.2m)
2012 – 2020 The Netherlands Organisation for Scientific Research (NWO). ‘Adult mesenchymal stem cells (MSC) to regenerate the neonatal brain’ (Co-PIs Prof Annemieke Kavelaars and Prof Linda de Vries). Co-applicant and neuro-imaging workpackage leader. (€1.7m)
2012 Grant Health Insurance company: Nuts-Ohra: ‘Neuromonitoring during neonatal surgery, and evaluating brain injury with MRI and long-term outcome’. (PI Petra Lemmers). Co-applicant, supervised PhD student: Lisanne Stolwijk. (€160k+50k)
2013 Irish Medical Research Council: ‘Automatic analysis of brain injury in MRI of asphyxiated infants’. Co-applicant supervised post-doctoral Fellow (Dr Keelin Murphy). (€100k)
2013 Univeristy Medical Center Utrecht / Wilhelmina Children’s hospital Foundation: ‘White matter injury of the preterm infants’, animal experimental study.’ (PI Dr Cora Nijboer). Supervised PhD student: Erik van Tilborg (€150k +€50k UMCU)
2014 Univeristy Medical Center Utrecht / Wilhelmina Children’s hospital foundation: ‘Anatomical brain networks and its functional dynamics in neonates : a biomarker for cognitive outcome’. (PI Dr Martijn van de Heuvel). Supervised PhD student: Kristin Keunen (€150k+€50k UMCU)
2016 IGLOInsuline like growth factor levels and outcome in extreme premature infants: Brain foundation. The Next Step HA2016-02-04. (co-applicant) (€480.000)
2016 Univeristy Medical Center Utrecht / Wilhelmina Children’s hospital foundation: The effects of preterm birth of stressresilience during childhood. WKZ foundation. (co-applicant) €150.000 Femke Lammertink
Consultancy - . - Chiesi
