Metabolism, Stem cells and Cancer
metabolism, stem cells, cancer, live imaging
Research aim
Our overarching goal is to gain deep molecular understanding of cancer and stem cell metabolism to enable the development of novel therapies to treat diseases with a particular interest in cancer.
About us
We are interested in how cellular metabolism is intertwined with every process in the cell. We study the cross-talk between cell signaling and metabolism in the context of normal tissue homeostasis and in cancer.
In our group we use different research models, i.a. cell lines and organoids. Organoids are derived from healthy and cancerous tissue and recapitulate, in vitro, tissue architecture, cell heterogeneity and the cellular interactions that take place in vivo. We apply and generate a number of analytic tools and pipelines to our research, such as Seahorse-based bioenergetic analysis, Omics such as Metabolomics, Proteomics and RNAseq, etc. We have a strong interest in live imaging of genetic encoded metabolic reporters and in-house developed machine learning based analytic pipelines.