Profile photo Sam van Beuningen

Sam van Beuningen

Assistant Professor

Biography

Sam van Beuningen is an Assistant Professor and leads a research team in AI and Automation for Cellular Disease models within the Department of Cellular Disease Models (UMC Utrecht) and the Regenerative Medicine Center Utrecht. He has an educational background in molecular biology and holds a PhD in cell biology from Utrecht University. During his PhD project, he gained extensive experience in various molecular biology and advanced microscopy techniques at the Department of Cell Biology (Utrecht University). After obtaining his PhD, Sam continued his career as a Data Science consultant for various large Dutch enterprises. Here he developed various data and machine-learning solutions to improve business processes. Since 2021 he is working within the Centre for Living Technologies where he combines his molecular biology and microscopy knowledge with his data science experience. Sam and his team run the Cellular Screening Technologies facility and the AI lab for Living Technologies where they develop automated lab and AI pipelines for the screening and analysis of patient derived technologies.

Research groups

Cellular disease models

Research aim

To develop patient-derived cell models to understand the molecular mechanisms of disease, to identify and validate targets for treatment, and to develop drugs and precision medicine applications.

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Pediatric pulmonology

Research aim

We unravel biological, clinical and psychosocial aspects of lung diseases like Cystic Fibrosis, Primary Ciliary Dyskinesia and oncology to continuously improve diagnosis and treatment by implementing latest scientific insights into clinical care.

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Recent publications

OrgaSegment Juliet W Lefferts, Suzanne Kroes, Matthew B Smith, Paul J Niemöller, Natascha D A Nieuwenhuijze, Heleen N Sonneveld van Kooten, Cornelis K van der Ent, Jeffrey M Beekman, Sam F B van Beuningen
Communications biology, 2024, vol. 7
CFTR Function Restoration upon Elexacaftor/Tezacaftor/Ivacaftor Treatment in Patient-Derived Intestinal Organoids with Rare CFTR Genotypes. Juliet W Lefferts, Marlou C Bierlaagh, Suzanne Kroes, Natascha D A Nieuwenhuijze, Heleen N Sonneveld van Kooten, Paul J Niemöller, Tibo F Verburg, Hettie M Janssens, Danya Muilwijk, Sam F B van Beuningen, Cornelis K van der Ent, Jeffrey M Beekman
International Journal of Molecular Sciences, 2023, vol. 24
Drug Repurposing for Cystic Fibrosis Lisa W. Rodenburg, Livia Delpiano, Violeta Railean, Raquel Centeio, Madalena C. Pinto, Shannon M.A. Smits, Isabelle S. van der Windt, Casper F.J. van Hugten, Sam F.B. van Beuningen, Remco N.P. Rodenburg, Cornelis K. van der Ent, Margarida D. Amaral, Karl Kunzelmann, Michael A. Gray, Jeffrey M. Beekman, Gimano D. Amatngalim
International Journal of Molecular Sciences, 2022, vol. 23
Trim46 organizes microtubule fasciculation in the axon initial segment Martin Harterink, Karin Vocking, Xingxiu Pan, Eva M. Soriano Jerez, Lotte Slenders, Amélie Fréal, Roderick P. Tas, Willine J. Van De Wetering, Karina Timmer, Jasmijn Motshagen, Sam F.B. Van Beuningen, Lukas C. Kapitein, Willie J.C. Geerts, Jan A. Post, Casper C. Hoogenraad
Journal of Neuroscience, 2019, vol. 39, p.4864-4873
Antibodies to TRIM46 are associated with paraneoplastic neurological syndromes Marleen H. van Coevorden-Hameete, Sam F.B. van Beuningen, Matthieu Perrenoud, Lena M. Will, Esther Hulsenboom, Jean Francois Demonet, Lidia Sabater, Johan M. Kros, Jan J.G.M. Verschuuren, Maarten J. Titulaer, Esther de Graaff, Peter A.E. Sillevis Smitt, Casper C. Hoogenraad
Annals of Clinical and Translational Neurology, 2017, vol. 4, p.680-686
Neuronal polarity Sam F.B. van Beuningen, Casper C. Hoogenraad
Current Opinion in Neurobiology, 2016, vol. 39, p.1-7