Sam van Beuningen

Assistant Professor

Strategic program(s):

Contact

sbeuning@umcutrecht.nl

Pure profile

Research groups

Cellular disease models

Research aim

To develop patient-derived cell models to understand the molecular mechanisms of disease, to identify and validate targets for treatment, and to develop drugs and precision medicine applications.

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Pediatric pulmonology

Research aim

We unravel biological, clinical and psychosocial aspects of lung diseases like Cystic Fibrosis, Primary Ciliary Dyskinesia and oncology to continuously improve diagnosis and treatment by implementing latest scientific insights into clinical care.

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Recent publications

All publications

OrgaSegment Juliet W Lefferts, Suzanne Kroes, Matthew B Smith, Paul J Niemöller, Natascha D A Nieuwenhuijze, Heleen N Sonneveld van Kooten, Cornelis K van der Ent, Jeffrey M Beekman, Sam F B van Beuningen
Communications biology, 2024, vol. 7

CFTR Function Restoration upon Elexacaftor/Tezacaftor/Ivacaftor Treatment in Patient-Derived Intestinal Organoids with Rare CFTR Genotypes. Juliet W Lefferts, Marlou C Bierlaagh, Suzanne Kroes, Natascha D A Nieuwenhuijze, Heleen N Sonneveld van Kooten, Paul J Niemöller, Tibo F Verburg, Hettie M Janssens, Danya Muilwijk, Sam F B van Beuningen, Cornelis K van der Ent, Jeffrey M Beekman
International Journal of Molecular Sciences, 2023, vol. 24

Drug Repurposing for Cystic Fibrosis Lisa W. Rodenburg, Livia Delpiano, Violeta Railean, Raquel Centeio, Madalena C. Pinto, Shannon M.A. Smits, Isabelle S. van der Windt, Casper F.J. van Hugten, Sam F.B. van Beuningen, Remco N.P. Rodenburg, Cornelis K. van der Ent, Margarida D. Amaral, Karl Kunzelmann, Michael A. Gray, Jeffrey M. Beekman, Gimano D. Amatngalim
International Journal of Molecular Sciences, 2022, vol. 23

Trim46 organizes microtubule fasciculation in the axon initial segment Martin Harterink, Karin Vocking, Xingxiu Pan, Eva M. Soriano Jerez, Lotte Slenders, Amélie Fréal, Roderick P. Tas, Willine J. Van De Wetering, Karina Timmer, Jasmijn Motshagen, Sam F.B. Van Beuningen, Lukas C. Kapitein, Willie J.C. Geerts, Jan A. Post, Casper C. Hoogenraad
Journal of Neuroscience, 2019, vol. 39, p.4864-4873

Antibodies to TRIM46 are associated with paraneoplastic neurological syndromes Marleen H. van Coevorden-Hameete, Sam F.B. van Beuningen, Matthieu Perrenoud, Lena M. Will, Esther Hulsenboom, Jean Francois Demonet, Lidia Sabater, Johan M. Kros, Jan J.G.M. Verschuuren, Maarten J. Titulaer, Esther de Graaff, Peter A.E. Sillevis Smitt, Casper C. Hoogenraad
Annals of Clinical and Translational Neurology, 2017, vol. 4, p.680-686

Neuronal polarity Sam F.B. van Beuningen, Casper C. Hoogenraad
Current Opinion in Neurobiology, 2016, vol. 39, p.1-7