Profile photo Kors van der Ent

Kors van der Ent

Full Professor

Strategic program(s):

Biography

The research interests of professor Kors van der Ent focus on the themes Cystic Fibrosis and other bronchusobstructive diseseases in young children. He is the leader of the national HIT-CF program which focuses on the development and personalised application of new drugs influencing the basis genetic defect in patients with CF. This program includes both mechanistic studies in collaboration with the Hubrecht lab and the Byvoet Center as well as studies into host pathogen interaction in collaboration with the veterinary faculty of the Utrecht University. Clinical studies are performed in close collaboration with other CF-centres throughout Europe. Furthermore, he was the founder of the Whistler birth cohort, in which thousands of children are followed from birth to study determinants of the development of respiratory diseases. These cohorts mirror normal development to understand mechanisms in disease.

Kors van der Ent has special interest in innovation and valorisation in medical care and believes in creation of hospital networks to build the future medical care system for children. He successfully developed new devices to measure neonatal lung function, which were launched to the market. He also developed the Luchtwegportaal, an interactive web-based system to collect patient data regarding respiratory diseases in many hospitals in The Netherlands.

Research groups

Cellular disease models

Research aim

To develop patient-derived cell models to understand the molecular mechanisms of disease, to identify and validate targets for treatment, and to develop drugs and precision medicine applications.

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Pediatric pulmonology

Research aim

We unravel biological, clinical and psychosocial aspects of lung diseases like Cystic Fibrosis, Primary Ciliary Dyskinesia and oncology to continuously improve diagnosis and treatment by implementing latest scientific insights into clinical care.

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Recent publications

The Effect of Disease-Modifying Therapies on Lung Function and Respiratory Muscle Strength in Spinal Muscular Atrophy Kim Kant-Smits, Bart Bartels, Laura van der Heiden, Esther S Veldhoen, Kors van der Ent, W Ludo van der Pol, Erik H J Hulzebos
Respiratory Care, 2025, vol. 70, p.337-348
Elexacaftor/tezacaftor/ivacaftor efficacy in intestinal organoids with rare CFTR variants in comparison to CFTR-F508del and CFTR-wild type controls Suzanne Kroes, Marlou C. Bierlaagh, Juliet W. Lefferts, Alessandra Boni, Danya Muilwijk, Carla Viscomi, Natascha D.A. Keijzer-Nieuwenhuijze, Luca Cristiani, Paul J. Niemöller, Tibo F. Verburg, Renato Cutrera, Alessandro G. Fiocchi, Vincenzina Lucidi, Cornelis K. van der Ent, Jeffrey M. Beekman, Federico Alghisi, Fabiana Ciciriello
Journal of Cystic Fibrosis, 2024, vol. 24, p.175-182
Physical Activity Levels, Cardiorespiratory Fitness, and Physical Literacy in Children with a Chronic Medical Condition Johannes J. Noordstar, Maaike C.A. Sprong, Martijn G. Slieker, Tim Takken, Cornelis K. Van Der Ent, Marco Van Brussel, Marije Bartels, Erik H.J. Hulzebos
Pediatric Physical Therapy, 2024, vol. 37, p.30-35
Early-Life Risk Factors for Carotid Intima-Media Thickness and Carotid Stiffness in Adolescence Isabelle A van der Linden, Rozan Roodenburg, Sanne L Nijhof, Cornelis K van der Ent, Roderick P Venekamp, Sabine E I van der Laan, Henk S Schipper
JAMA network open, 2024, vol. 7
Physical activity, sedentary behaviour, and childhood asthma Marianne Eijkemans, Monique Mommers, Margreet W. Harskamp-van Ginkel, Tanja G.M. Vrijkotte, Johnny Ludvigsson, Åshild Faresjö, Anna Bergström, Sandra Ekström, Veit Grote, Berthold Koletzko, Klaus Bønnelykke, Anders Ulrik Eliasen, Peter Bager, Mads Melbye, Isabella Annesi-Maesano, Nour Baïz, Henrique Barros, Ana Cristina Santos, Liesbeth Duijts, Sara M. Mensink-Bout, Claudia Flexeder, Sibylle Koletzko, Tamara Schikowski, Merete Åse Eggesbø, Virissa Lenters, Guillermo Fernández-Tardón, Mikel Subiza-Perez, Judith Garcia-Aymerich, Mónica López-Vicente, Jordi Sunyer, Maties Torrent, Ferran Ballester, Cecily Kelleher, John Mehegan, Andrea von Berg, Gunda Herberth, Marie Standl, Claudia E. Kuehni, Eva S.L. Pedersen, Maria Jansen, Ulrike Gehring, Jolanda M.A. Boer, Graham Devereux, Steve Turner, Ville Peltola, Hanna Lagström, Hazel M. Inskip, Katharine C. Pike, Geertje W. Dalmeijer, Cornelis K.van der Ent, Carel Thijs
BMJ open respiratory research, 2024, vol. 11
Repeatability and reproducibility of the Forskolin-induced swelling (FIS) assay on intestinal organoids from people with Cystic Fibrosis Marlou C. Bierlaagh, Anabela S. Ramalho, Iris A.L. Silva, Annelotte M. Vonk, Rutger M. van den Bor, Peter van Mourik, Johanna Pott, Sylvia W.F. Suen, Sylvia F. Boj, Robert G.J. Vries, Elise Lammertyn, François Vermeulen, Margarida D. Amaral, Kris de Boeck, Cornelis K. van der Ent, Jeffrey M. Beekman
Journal of Cystic Fibrosis, 2024, vol. 23, p.693-702

Fellowships & Awards

European CF young investigator meeting award 2011. A functional CFTR assay using primary cystic fibrosis organoids

European CF basic science meeting award 2011. Treatment with VX809 and VX770 in rectal CF organoids expressing  uncommon CFTR genotypes

European CF basic science meeting award 2012. Characterizing altered inflammatory signaling in CFTR-defective

bronchial epithelial cells

National symposium Dutch CF foundation award 2011. Complement mediated phagocytosis is reduced in CF monocytes.

External positions

lid van Wetenschappelijke Advies Raad (WAR) SKZ - Gevraagd en ongevraagd advies geven tav wetenschappelijk beleid van SKZ - Sophia Kinderziekenhuis Rotterdam

Voorzitter Jurycommissie - Advies en voorzitten van jurycommissies van KBS - Koning Boudewijnstichting

Consultant - Advisory services on trial development and patient recruitment - ReCode Therapeutics

Voorzitter Stichting - Inhoudelijke deskundigheid - Stichting Fair Therapeutics

Lid van Data Safety Monitoring Board - inhoudelijke expertise clinical research - Cystic Fibrosis Foundation

Algemeen bestuurslid - Expertise Kliniek en Research - Long Alliantie Nederland

Bestuurslid van St Malawi Mission Work Team - Expertise als algemeen kinderarts - St Malawi Mission Work Team