Karin de Winter-de Groot

PHD Candidate - Medical

Strategic program(s):

Contact

kwinter@umcutrecht.nl

Pure profile

Research groups

Cellular disease models

Research aim

To develop patient-derived cell models to understand the molecular mechanisms of disease, to identify and validate targets for treatment, and to develop drugs and precision medicine applications.

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Pediatric pulmonology

Research aim

We unravel biological, clinical and psychosocial aspects of lung diseases like Cystic Fibrosis, Primary Ciliary Dyskinesia and oncology to continuously improve diagnosis and treatment by implementing latest scientific insights into clinical care.

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Recent publications

All publications

Letter to the editor E. De Wachter, J. C. Davies, N. J. Simmonds, C. Castellani, K. M. de Winter-de Groot, A. Munck, M. Proesmans, K. W. Southern, J. Barben
Journal of Cystic Fibrosis, 2023, vol. 23, p.176-177

FDA-approved drug screening in patient-derived organoids demonstrates potential of drug repurposing for rare cystic fibrosis genotypes E. de Poel, S. Spelier, M. C. Hagemeijer, P. van Mourik, S. W.F. Suen, A. M. Vonk, J. E. Brunsveld, G. N. Ithakisiou, E. Kruisselbrink, H. Oppelaar, G. Berkers, K. M. de Winter de Groot, S. Heida-Michel, S. R. Jans, H. van Panhuis, M. Bakker, R. van der Meer, J. Roukema, E. Dompeling, E. J.M. Weersink, G. H. Koppelman, A. R. Blaazer, J. E. Muijlwijk-Koezen, C. K. van der Ent, J. M. Beekman
Journal of Cystic Fibrosis, 2023, vol. 22, p.548-559

16S rRNA-Based Microbiota Profiling Assists Conventional Culture Analysis of Airway Samples from Pediatric Cystic Fibrosis Patients Maartje Kristensen, Emma M de Koff, Mei Ling Chu, Simone Groendijk, Gerdien A Tramper-Stranders, Karin M de Winter-de Groot, Hettie M Janssens, Harm A Tiddens, Mireille van Westreenen, Elisabeth A M Sanders, Bert H G M Arets, Cornelis K van der Ent, Sabine M P J Prevaes, Debby Bogaert
Microbiology spectrum, 2023, vol. 11, p.1-8

Organoid-guided synergistic treatment of minimal function CFTR mutations with CFTR modulators, roflumilast and simvastatin Sacha Spelier, Karin de Winter-de Groot, Natascha Keijzer-Nieuwenhuijze, Yves Liem, Kors van der Ent, Jeffrey Beekman, Lieke S. Kamphuis
The European respiratory journal, 2023, vol. 63

Optimization of performance of Dutch newborn screening for cystic fibrosis M J Bouva, J E Dankert-Roelse, Cpb van der Ploeg, R K Verschoof-Puite, D D Zomer-van Ommen, Jjp Gille, B S Jakobs, Mla Heijnen, K M de Winter-de Groot
Journal of Cystic Fibrosis, 2023, vol. 23, p.120-125

European survey of newborn bloodspot screening for CF Anne Munck, Daria O Berger, Kevin W Southern, Carla Carducci, Karin M de Winter-de Groot, Silvia Gartner, Nataliya Kashirskaya, Barry Linnane, Marijke Proesmans, Dorota Sands, Olaf Sommerburg, Carlo Castellani, Jürg Barben,
Journal of Cystic Fibrosis, 2023, vol. 22, p.484-495