Profile photo Marjolein de Bruin-Weller

Marjolein de Bruin-Weller

Full Professor

Strategic program(s):

Biography

Marjolein de Bruin-Weller  is a dermatologist and full professor in atopic dermatitis and head of the National Expertise Center of Atopic Dermatitis,  situated  in the dpt. of Dermatology and Allergology of the University Medical Center of Utrecht, The Netherlands

 

After her training in physiotherapy (1979-1983), she started her medical training at the University of Leiden and graduated in 1990. After this she started as a PhD candidate at Astmacenter Heideheuvel, Hilversum, the Netherlands, supervised by Professor Jan de Monchy (allergologist  University Medical Center Groningen, Professor Henk Jansen (pulmonologist University Medical Center Amsterdam) and dr. Frank Weller (pulmonologist University Medical Center Amsterdam).  In 1997 she defended her PhD thesis “Dynamics of the allergic reaction in the airways and the skin”  at the University of Groningen.

 

She started her training in dermatology in 1997 at the department of Dermatology/Allergology of the University Medical Center Utrecht and became a staff member at this department in 2001, with a special focus on atopic dermatitis.  In October 2018 she was appointed as Associate Professor and in December 2021 as full professor in atopic dermatitis.

Her major interest is clinical and translational research in atopic dermatitis. She is principle investigator in several clinical trials and investigator-initiated studies focused on difficult to treat atopic dermatitis and systemic immunosuppressive and immuno-modulating treatment. For translational, she closely collaborates with the Center of Translational Immunology in Utrecht (Professor Femke van Wijk).

Together with Femke van Wijk, Marjolein de Bruin leads the Utrecht Atopic Dermatitis Research Group.

 

In 2018 she imitated  the BioDay Registry in the Netherlands together with dr. Marie-Louise Schuttelaar from the department of Dermatology of the University Medical Center of Groningen. This register is focused on new systemic treatments in atopic dermatitis and includes a lot of data concerning atopic dermatitis (signs, symptoms, quality of life, work impairment) as well as data concerning atopic co-morbidities. At the end of 2021, 14 centers in the Netherlands are participating in the BioDay Registry and   >1000 patients are included.

 

Marjolein de Bruin-Weller  is a member of the Expertise group Allergy and Eczema Dutch Society of Dermatology and Venereology),  the  European Task Force of Atopic Dermatitis  (ETFAD) , the International Eczema Council (IEC)  and the  GA²LEN ADCARE Task Force.  She is chair of the advisory board Dutch Patient Society for Atopic Dermatitis (VMCE).

 

 

 

Research groups

Atopic dermatitis

Research aim

By combining clinical and translational research the goal of our research is to improve personalized treatment of adult and pediatric atopic dermatitis patients. The ultimate goal is to achieve disease modification and prevent atopic comorbidities.

Go to group

Tissue immunology

Research aim

Our mission is to comprehensively understand, monitor, and target immune-mediated inflammatory diseases such as IBD, AD and systemic autoimmune diseases. We aim to unravel (tissue) immune dysregulation and induce long-lasting disease modification.

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Recent publications

Dupilumab als nieuw behandelperspectief bij prurigo nodularis Octavian Bacoș-Cosma, Sophie Engels, Lian van der Gang, Marjolein de Bruin-Weller, Laura Loman, Marie Louise Schuttelaar
Nederlands Tijdschrift voor Dermatologie en Venereologie, 2025, vol. 35, p.5-9
JAK-remmers bij constitutioneel eczeem Esmé Kamphuis, Tabitha Piet, Octavian Bacoș-Cosma, Lian van der Gang, Marjolein de Bruin-Weller, Laura Loman, Marie Louise Schuttelaar
Nederlands Tijdschrift voor Dermatologie en Venereologie, 2025, vol. 35, p.10-12
Reassuring evidence on infection risk with dupilumab in atopic dermatitis Lian F van der Gang, Marjolein S de Bruin-Weller
JEADV : journal of the European Academy of Dermatology and Venereology, 2025, vol. 39, p.2026-2027
Efficacy and safety of lebrikizumab in adult and adolescent patients with moderate-to-severe atopic dermatitis inadequately controlled with or ineligible for ciclosporin A Richard B. Warren, Marjolein De Bruin-Weller, Athanasios Tsianakas, Abdallah Khemis, Jacek C. Szepietowski, H. Chih Ho Hong, Yanislav Mihaylov, Meritxell Falqués, Helena Agell, Eric Massana, Esther Garcia Gil, Ruth Coll, Stephan Weidinger
British Journal of Dermatology, 2025, vol. 193, p.876-888
Efficacy and Safety of Upadacitinib in Patients With Moderate-to-Severe Atopic Dermatitis Alan D Irvine, Vimal H Prajapati, Emma Guttman-Yassky, Eric L Simpson, Kim A Papp, Andrew Blauvelt, Chia-Yu Chu, H Chih-Ho Hong, Linda F Stein Gold, Marjolein de Bruin-Weller, Thomas Bieber, Kenji Kabashima, David Rosmarin, Cristina Sancho, Brian M Calimlim, Ayman Grada, Yang Yang, Xiaoqiang Wu, Gweneth Levy, Eliza M Raymundo, Henrique D Teixeira, Jonathan I Silverberg
American Journal of Clinical Dermatology, 2025, vol. 26, p.1003-1016
Topical Steroid Withdrawal Florence Vroman, Charlotte S Schimmel, Lisa P Van der Rijst, Marlies De Graaf, Marjolein De Bruin-Weller, Patrick M J H Kemperman, Dirk Jan Hijnen, Inge M Haeck
Acta Dermato-Venereologica, 2025, vol. 105