Profile photo Marjolein de Bruin-Weller

Marjolein de Bruin-Weller

Full Professor

Strategic program(s):

Biography

Marjolein de Bruin-Weller  is a dermatologist and full professor in atopic dermatitis and head of the National Expertise Center of Atopic Dermatitis,  situated  in the dpt. of Dermatology and Allergology of the University Medical Center of Utrecht, The Netherlands

 

After her training in physiotherapy (1979-1983), she started her medical training at the University of Leiden and graduated in 1990. After this she started as a PhD candidate at Astmacenter Heideheuvel, Hilversum, the Netherlands, supervised by Professor Jan de Monchy (allergologist  University Medical Center Groningen, Professor Henk Jansen (pulmonologist University Medical Center Amsterdam) and dr. Frank Weller (pulmonologist University Medical Center Amsterdam).  In 1997 she defended her PhD thesis “Dynamics of the allergic reaction in the airways and the skin”  at the University of Groningen.

 

She started her training in dermatology in 1997 at the department of Dermatology/Allergology of the University Medical Center Utrecht and became a staff member at this department in 2001, with a special focus on atopic dermatitis.  In October 2018 she was appointed as Associate Professor and in December 2021 as full professor in atopic dermatitis.

Her major interest is clinical and translational research in atopic dermatitis. She is principle investigator in several clinical trials and investigator-initiated studies focused on difficult to treat atopic dermatitis and systemic immunosuppressive and immuno-modulating treatment. For translational, she closely collaborates with the Center of Translational Immunology in Utrecht (Professor Femke van Wijk).

Together with Femke van Wijk, Marjolein de Bruin leads the Utrecht Atopic Dermatitis Research Group.

 

In 2018 she imitated  the BioDay Registry in the Netherlands together with dr. Marie-Louise Schuttelaar from the department of Dermatology of the University Medical Center of Groningen. This register is focused on new systemic treatments in atopic dermatitis and includes a lot of data concerning atopic dermatitis (signs, symptoms, quality of life, work impairment) as well as data concerning atopic co-morbidities. At the end of 2021, 14 centers in the Netherlands are participating in the BioDay Registry and   >1000 patients are included.

 

Marjolein de Bruin-Weller  is a member of the Expertise group Allergy and Eczema Dutch Society of Dermatology and Venereology),  the  European Task Force of Atopic Dermatitis  (ETFAD) , the International Eczema Council (IEC)  and the  GA²LEN ADCARE Task Force.  She is chair of the advisory board Dutch Patient Society for Atopic Dermatitis (VMCE).

 

 

 

Research groups

Atopic dermatitis

Research aim

By combining clinical and translational research the goal of our research is to improve personalized treatment of adult and pediatric atopic dermatitis patients . The ultimate goal is to achieve disease modification and prevent atopic comorbidities.
Go to group

Tissue immunology

Research aim

Our mission is to comprehensively understand, monitor, and target immune-mediated inflammatory diseases such as IBD, AD and systemic autoimmune diseases. We aim to unravel (tissue) immune dysregulation and induce long-lasting disease modification.
Go to group

Recent publications

Real-world Experience of Abrocitinib Treatment in Patients with Atopic Dermatitis and Hand Eczema Esmé Kamphuis, Celeste M Boesjes, Laura Loman, Marijke Kamsteeg, Inge Haeck, Anneke M T Van Lynden-van Nes, Klaziena Politiek, Liana F Van der Gang, Marlies De Graaf, Marjolein S De Bruin-Weller, Marie L A Schuttelaar
Acta Dermato-Venereologica, 2024, vol. 104, p.1-9
Successful tapering of dupilumab in patients with atopic dermatitis with low disease activity Lotte S Spekhorst, Celeste M Boesjes, Laura Loman, Nicolaas P A Zuithoff, Daphne S Bakker, Esmé Kamphuis, Marijke Kamsteeg, Inge Haeck, Albert J Oosting, Paula P M van Lumig, Anneke M T van Lynden-van Nes, Ron A Tupker, Annebeth Flinterman, Floor M Garritsen, Wouter R H Touwslager, Marjolein S de Bruin-Weller, Marie-Louise Schuttelaar, Marlies de Graaf
British Journal of Dermatology, 2023, vol. 189, p.327-335
Dupilumab-Associated Lymphoid Reactions in Patients With Atopic Dermatitis Celeste M Boesjes, Lian F van der Gang, Daphne S Bakker, Tess A Ten Cate, Lotte S Spekhorst, Marlies de Graaf, Marijke R van Dijk, Marjolein S de Bruin-Weller
JAMA Dermatology, 2023, vol. 159, p.1240-1247
Effectiveness of Upadacitinib in Patients with Atopic Dermatitis including those with Inadequate Response to Dupilumab and/or Baricitinib Celeste M Boesjes, Liana F Van der Gang, Nicolaas P A Zuithoff, Daphne S Bakker, Lotte S Spekhorst, Inge Haeck, Marijke Kamsteeg, Marlies De Graaf, Marjolein S De Bruin-Weller
Acta Dermato-Venereologica, 2023, vol. 103
Dupilumab-associated ocular surface disease in atopic dermatitis patients Roselie Achten, Judith Thijs, Marlot van der Wal, Chantal van Luijk, Marlies de Graaf, Daphne Bakker, Joke de Boer, Femke van Wijk, Marjolein de Bruin-Weller
Allergy, 2023, vol. 78, p.2266-2276
The positive effect of dupilumab on comorbid asthma in patients with atopic dermatitis Lotte S Spekhorst, Marlies de Graaf, Lisa P van der Rijst, Nicolaas P A Zuithoff, René C Schweizer, Marijke Kamsteeg, Inge Haeck, Anneke M T van Lynden-van Nes, Paula van Lumig, Geertruida L E Romeijn, Marie-Louise Schuttelaar, Marjolein S de Bruin-Weller
Clinical and Translational Allergy, 2023, vol. 13

External positions

Chair working group “dure geneesmiddelen” NVDV

Advisory board member Aslan

Advisory board member Arena

Advisory board member and speaker Almirall

Advisory board member Eli Lilly

Advisory board member and speakerJanssen

Consultant, advisory board member and speaker Leo Pharma

Consultant, advisory board member and speaker Pfizer

Member Steering committee of the ADCARE Task Force

Member “ geneesmiddelencommissie FMS”

ExComm Member GA²LEN

consultant,advisory board member and speaker AbbVie

Advisory board member and speaker Galderma

Member Horizonscan inflammatory diseases (Zorginstituut Nederland)

Consultant, advisory board member and speaker Regeneron

Consultant, advisory board member and speaker Sanofi-Genzyme

Member International Eczema Council (IEC)

Member European Task Force of Atopic Dermatitis (ETFAD)

Chair Advisory board Dutch patient society for atopic dermatitis (VMCE)