Profile photo Jeffrey Beekman

Jeffrey Beekman

Full Professor

Biography

Dr. J.M. Beekman obtained a PhD in molecular immunology in 2004, and performed multiple post docs in molecular and cell biology within various immunological settings. In October 2010, he became principle investigator at the UMC Utrecht, and started a novel translational research line focusing on developing novel therapeutic strategies for cystic fibrosis, a genetic disease characterized by aberrant ion and fluid homeostasis at mucosal surfaces leading to chronic infection and inflammation and early death around the 3rd to 4th decade of life.

 

‘People with chronic diseases living healthy lives: I strive to create breakthrough solutions for clinical needs of people with chronic diseases by scientific research that focuses on the development of novel diagnostic or therapeutic approaches. This requires a multidisciplinary approach in which basic and clinical research is aligned, and integrated with needs of patients, the private sector and regulatory authorities. Currently, I am particularly proud of leading a team that developed a highly innovative diagnostic assay that enables individualized therapy for people with cystic fibrosis that lead to direct clinical impact for people within 4 years after the initial discovery.’

Research groups

Cellular disease models

Research aim

To develop patient-derived cell models to understand the molecular mechanisms of disease, to identify and validate targets for treatment, and to develop drugs and precision medicine applications.

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Pediatric pulmonology

Research aim

We unravel biological, clinical and psychosocial aspects of lung diseases like Cystic Fibrosis, Primary Ciliary Dyskinesia and oncology to continuously improve diagnosis and treatment by implementing latest scientific insights into clinical care.

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Recent publications

The response of rare CFTR mutations to specific modulator combinations Noemie Stanleigh, Michal Gur, Michal Shteinberg, Aryeh Weiss, Naama Sebbag-Sznajder, Deborah Duran, Myriam Grunewald, Liron Birimberg-Schwartz, Lea Pevzner, Ronen Bar-Yoseph, Jeffrey M. Beekman, Eitan Kerem, Michael Wilschanski, Batsheva Kerem
ERJ Open Research, 2025, vol. 11
Lung organoids Lorenzo Zanetto, Luca Bonadies, Raquel Moll-Diaz, Michela Pozzobon, Eugenio Baraldi, Jeffrey Beekman, Maurizio Muraca
European Respiratory Review, 2025, vol. 34
The Promising Role of Intestinal Organoids in the Diagnostic Work-Up of Cystic Fibrosis Screen Positive Inconclusive Diagnosis/CFTR-Related Metabolic Syndrome (CFSPID/CRMS) Noelia Rodriguez Mier, Marlies Destoop, Sacha Spelier, Anabela Santo Ramalho, Jeffrey M Beekman, François Vermeulen, Marijke Proesmans, Karin M de Winter-de Groot
International Journal of Neonatal Screening, 2025, vol. 11
ACE-tRNAs are a platform technology for suppressing nonsense mutations that cause cystic fibrosis Wooree Ko, Joseph J Porter, Sacha Spelier, Emily G Sorensen, Priyanka Bhatt, Jeffrey T Gabell, Isabelle van der Windt, Tyler Couch, Kevin Coote, Martin Mense, Jeffrey M Beekman, John D Lueck
Nucleic acids research, 2025, vol. 53
Dual RNA sequencing of a co-culture model of Pseudomonas aeruginosa and human 2D upper airway organoids Cayetano Pleguezuelos-Manzano, Wouter A.G. Beenker, Gijs J.F. van Son, Harry Begthel, Gimano D. Amatngalim, Jeffrey M. Beekman, Hans Clevers, Jeroen den Hertog
Scientific Reports, 2025, vol. 15
Elexacaftor/tezacaftor/ivacaftor efficacy in intestinal organoids with rare CFTR variants in comparison to CFTR-F508del and CFTR-wild type controls Suzanne Kroes, Marlou C. Bierlaagh, Juliet W. Lefferts, Alessandra Boni, Danya Muilwijk, Carla Viscomi, Natascha D.A. Keijzer-Nieuwenhuijze, Luca Cristiani, Paul J. Niemöller, Tibo F. Verburg, Renato Cutrera, Alessandro G. Fiocchi, Vincenzina Lucidi, Cornelis K. van der Ent, Jeffrey M. Beekman, Federico Alghisi, Fabiana Ciciriello
Journal of Cystic Fibrosis, 2024, vol. 24, p.175-182

External positions

Professor Cellulaire Ziektemodellen - Sporadische activiteiten als consultant voor FAIR therapeutics - FAIR Therapeutics

Board member - Organisatie congres en activiteiten van de Dutch Society for Stem Cell Research - Dutch Society for Stem Cell Research