“High Risk” denotes research in patients that are at a particularly high risk for developing a first clinical or subsequent cardiovascular event. Many patients in the focus areas of the program have such elevated risk (in particular patients with hypertension, diabetes, atherosclerosis), and require optimal selection of primary or secondary preventive interventions. They are subject of targeted research.
Certain groups stand out with regard to identifiable risk factors and are at particular interest for the research program. The patient groups hypertension, type 2 diabetes and patients with female-specific risk factors cover an area of closely related risk factors and diseases leading to increased cardiovascular risk. The main group hypertension has a specific focus on complicated hypertension. Diabetes has a specific focus on type 2 diabetes and cardiovascular diseases. The group of patients with female-specific risk factors has a focus on HELLP, gestational diabetes, PCOS and POF. For etiologic, diagnostic, prognostic and therapeutic research regarding the relations between hypertension/diabetes mellitus/female-specific risk factors and vascular disease, three cross-connections can be identified: insulin resistance (obesity, metabolic syndrome, PCOS, HIV), sympathetic activity (new interventions, chronic kidney disease) and vascular stiffness/media calcification (vascular imaging, vascular ageing, pseudoxanthoma elasticum). These cross-links between hypertension and diabetes mellitus work synergistically and create a unique and integrated translational research network with a strong focus on patient outcomes and novel therapies.
Research groups play a pivotal role in advancing knowledge and innovation within their respective fields. By bringing together diverse experts, they foster collaborative efforts that drive scientific and technological breakthroughs.
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