Wouter van Rheenen

Assistant Professor

Strategic program(s):

Contact

wrheene2@umcutrecht.nl

Pure profile

Research groups

Neurogenetics

Research aim

Given increasing possibilities in gene-based therapies for ALS, the overall aim of my research is to elucidate the exact genetic contribution in every patient to liability to disease.

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Clinical spectrum of motor neuron disease

Research aim

Motor neuron disease (MND) are a collection of disorder that primarily lead to progressive weakness and/or spasticity. The goal is better understand and treat the extensive clinical heterogeneity in MND.

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Recent publications

All publications

The role of disease-associated short tandem repeats in amyotrophic lateral sclerosis Joke J F A van Vugt, Ramona A J Zwamborn, Egor Dolzhenko, Michael A Eberle, Ben Weisburd, Erwin Bekema, Maarten Kooyman, Bi-Nan Wang, Erik-Jan Kamsteeg, Monique Losekoot, Frank Baas, Camilla Novy, Helle Høyer, Ruben P A van Eijk, Michael A van Es, Wouter van Rheenen, Ammar Al-Chalabi, Leonard H van den Berg, Jan H Veldink,
Brain communications, 2025, vol. 7

Dissecting epigenetic age acceleration in amyotrophic lateral sclerosis Polina Merbaum, Ramona Zwamborn, Paul Hop, Project Min E.ALS Sequencing Consortium, Wouter van Rheenen, Jan Veldink
Epigenomics, 2025, vol. 17, p.1153-1161

Comprehensive analysis across SMN2 excludes DNA methylation as an epigenetic biomarker for spinal muscular atrophy Maria M. Zwartkruis, Joris V. Kortooms, Demi Gommers, Martin G. Elferink, Ilaria Signoria, Joyce van der Sel, Paul J. Hop, Ramona A.J. Zwamborn, Robin Geene, Jared W. Green, Hanneke W.M. van Deutekom, Wouter van Rheenen, Jan H. Veldink, Fay Lynn Asselman, Renske I. Wadman, W. Ludo van der Pol, Gijs W. van Haaften, Ewout J.N. Groen
iScience, 2025, vol. 28

UNC13A Polymorphism Influences Survival in Patients with Frontotemporal Dementia Lianne M. Reus, Sean W. Willemse, Sterre C.M. de Boer, Julie De Houwer, Willem L. Hartog, Merel O. Mol, Jeroen G.J. van Rooij, Niccolo Tesi, Laura Donker Kaat, Marc Hulsman, Everard G.B. Vijverberg, Henne Holstege, Wouter van Rheenen, Jan H. Veldink, Leonard H. van den Berg, John C. van Swieten, H. Seelaar, Sven J. van der Lee, Michael A. van Es, Yolande A.L. Pijnenburg
Annals of Neurology, 2025, vol. 97, p.1062-1066

An observational study of pleiotropy and penetrance of amyotrophic lateral sclerosis associated with CAG-repeat expansion of ATXN2 Koen C. Demaegd, Aoife Kernan, Johnathan Cooper-Knock, Joke J.F.A. van Vugt, Calum Harvey, Tobias Moll, David O’Brien, Sarah Gornall, Luke Drury, Sali M.K. Farhan, Patrick A. Dion, Guy A. Rouleau, Andrea Western, Paul J. Parsons, Benjamin Mclean, Michael Benatar, Leonard H. van den Berg, Philip Van Damme, Jan Willem Dankbaar, Jeroen Hendrikse, Wouter Koole, Charlotte de Bie, Esther Hobson, Jan H. Veldink, Bart van de Warrenburg, R. Jeroen Pasterkamp, Wouter van Rheenen, Janine Kirby, Pamela J. Shaw, Michael A. van Es
European Journal of Human Genetics, 2025, vol. 33, p.1106-1112

Diagnosing primary lateral sclerosis Eva M J de Boer, Bálint S de Vries, Wim Van Hecke, Angelika Mühlebner, Koen L Vincken, Christian P Mol, Wouter van Rheenen, Henk-Jan Westeneng, Jan H Veldink, Günter U Höglinger, Huw R Morris, Irene Litvan, Joost Raaphorst, Nicola Ticozzi, Philippe Corcia, Wim Vandenberghe, Yolande A L Pijnenburg, Harro Seelaar, Caroline Ingre, Philip Van Damme, Leonard H van den Berg, Bart P C van de Warrenburg, Michael A van Es
Journal of Neurology, 2024, vol. 272

External positions

No external positions -