Wouter van Rheenen

Assistant Professor

Strategic program(s):

Contact

wrheene2@umcutrecht.nl

Pure profile

Research groups

Neurogenetics

Research aim

Given increasing possibilities in gene-based therapies for ALS, the overall aim of my research is to elucidate the exact genetic contribution in every patient to liability to disease.

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Clinical spectrum of motor neuron disease

Research aim

Motor neuron disease (MND) are a collection of disorder that primarily lead to progressive weakness and/or spasticity. The goal is better understand and treat the extensive clinical heterogeneity in MND.

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Recent publications

All publications

Bi-allelic intermediate ATXN2 repeat expansions are associated with slow progressing, leg-onset familial ALS Koen Cedric Demaegd, Wouter Koole, Joke JFA Van Vugt, Jan Willem Dankbaar, Jeroen Hendrikse, A. Nazlı Başak, Mamede De Carvalho, Philippe Corcia, Philippe Codron, Emilien Bernard, Claire Guissart, Philippe Couratier, Mónica Povedano Panades, Pieter A. Van Doorn, Bart P. Warrenburg, Johnathan Cooper-Knock, R. Jeroen Pasterkamp, Wouter Van Rheenen, Philip Van Damme, Leonard H. Van den Berg, Jan Herman Veldink, Michael A. Van Es, Patrick Vourc’h, Orla Hardiman, Russell McLaughin, Marc Gotkine, Yossef Lerner, Vivian Drory, Nicola Ticozzi, Vincenzo Silani, Teresa Salas, S. Jesus, Mora Pardina, Peter Andersen, Markus Weber, Ammar Al-Chalabi, Chris Shaw, Pamela J. Shaw, Karen E. Morrison, John E. Landers, Jonathan D. Glass, Clifton L. Dalgard
BMJ Neurology Open, 2026, vol. 8

The role of disease-associated short tandem repeats in amyotrophic lateral sclerosis Joke J F A van Vugt, Ramona A J Zwamborn, Egor Dolzhenko, Michael A Eberle, Ben Weisburd, Erwin Bekema, Maarten Kooyman, Bi-Nan Wang, Erik-Jan Kamsteeg, Monique Losekoot, Frank Baas, Camilla Novy, Helle Høyer, Ruben P A van Eijk, Michael A van Es, Wouter van Rheenen, Ammar Al-Chalabi, Leonard H van den Berg, Jan H Veldink,
Brain communications, 2025, vol. 7

Dissecting epigenetic age acceleration in amyotrophic lateral sclerosis Polina Merbaum, Ramona Zwamborn, Paul Hop, Project Min E.ALS Sequencing Consortium, Wouter van Rheenen, Jan Veldink
Epigenomics, 2025, vol. 17, p.1153-1161

A VAPB (P56S) mutation in a Dutch patient with familial motor neuron disease Sean W. Willemse, Koen C. Demaegd, Ruben P.A. Van Eijk, Philippe Van Damme, Elizabeth Harrington, Matthew B. Harms, Neil A. Shneider, Wouter Van Rheenen, Jan H. Veldink, Leonard H. Van Den Berg, Michael A. Van Es
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 2025, vol. 27, p.227-229

Comprehensive analysis across SMN2 excludes DNA methylation as an epigenetic biomarker for spinal muscular atrophy Maria M. Zwartkruis, Joris V. Kortooms, Demi Gommers, Martin G. Elferink, Ilaria Signoria, Joyce van der Sel, Paul J. Hop, Ramona A.J. Zwamborn, Robin Geene, Jared W. Green, Hanneke W.M. van Deutekom, Wouter van Rheenen, Jan H. Veldink, Fay Lynn Asselman, Renske I. Wadman, W. Ludo van der Pol, Gijs W. van Haaften, Ewout J.N. Groen
iScience, 2025, vol. 28

UNC13A Polymorphism Influences Survival in Patients with Frontotemporal Dementia Lianne M. Reus, Sean W. Willemse, Sterre C.M. de Boer, Julie De Houwer, Willem L. Hartog, Merel O. Mol, Jeroen G.J. van Rooij, Niccolo Tesi, Laura Donker Kaat, Marc Hulsman, Everard G.B. Vijverberg, Henne Holstege, Wouter van Rheenen, Jan H. Veldink, Leonard H. van den Berg, John C. van Swieten, H. Seelaar, Sven J. van der Lee, Michael A. van Es, Yolande A.L. Pijnenburg
Annals of Neurology, 2025, vol. 97, p.1062-1066

External positions

No external positions -