Wouter van Rheenen

Assistant Professor

Strategic program(s):

Contact

wrheene2@umcutrecht.nl

Pure profile

Research groups

Neurogenetics

Research aim

Given increasing possibilities in gene-based therapies for ALS, the overall aim of my research is to elucidate the exact genetic contribution in every patient to liability to disease.

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Clinical spectrum of motor neuron disease

Research aim

Motor neuron disease (MND) are a collection of disorder that primarily lead to progressive weakness and/or spasticity. The goal is better understand and treat the extensive clinical heterogeneity in MND.

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Recent publications

All publications

Mechanism-free repurposing of drugs for C9orf72-related ALS/FTD using large-scale genomic data Sara Saez-Atienzar, Cleide dos Santos Souza, Ruth Chia, Selina N. Beal, Ileana Lorenzini, Ruili Huang, Jennifer Levy, Camelia Burciu, Jinhui Ding, J. Raphael Gibbs, Ashley Jones, Ramita Dewan, Viviana Pensato, Silvia Peverelli, Lucia Corrado, Joke J.F.A. van Vugt, Wouter van Rheenen, Ceren Tunca, Elif Bayraktar, Menghang Xia, Robert H. Baloh, Robert Bowser, Christopher B. Brady, Alexis Brice, James Broach, William Camu, Adriano Chio, John Cooper-Knock, Daniele Cusi, Carsten Drepper, Vivian E. Drory, Travis L. Dunckley, Eva Feldman, Mary Kay Floeter, Pietro Fratta, Glenn Gerhard, Summer B. Gibson, Jonathan D. Glass, Stephen A. Goutman, John Hardy, Matthew B. Harms, Terry D. Heiman-Patterson, Lilja Jansson, Janine Kirby, Hannu Laaksovirta, John E. Landers, Russell McLaughlin, Kevin Kenna, Leonard H. van den Berg, Jan H. Veldink, , , ,
Cell genomics, 2024, vol. 4

Diagnosing primary lateral sclerosis Eva M J de Boer, Bálint S de Vries, Wim Van Hecke, Angelika Mühlebner, Koen L Vincken, Christian P Mol, Wouter van Rheenen, Henk-Jan Westeneng, Jan H Veldink, Günter U Höglinger, Huw R Morris, Irene Litvan, Joost Raaphorst, Nicola Ticozzi, Philippe Corcia, Wim Vandenberghe, Yolande A L Pijnenburg, Harro Seelaar, Caroline Ingre, Philip Van Damme, Leonard H van den Berg, Bart P C van de Warrenburg, Michael A van Es
Journal of Neurology, 2024, vol. 272

The imputation of C9orf72 repeat expansions in GWAS data Polina Merbaum, Wouter van Rheenen, Jan Veldink
2024

Assessment of risk of ALS conferred by the GGGGCC hexanucleotide repeat expansion in C9orf72 among first-degree relatives of patients with ALS carrying the repeat expansion Iris F. Van Wijk, Ruben P.A. Van Eijk, Loes Van Boxmeer, Henk Jan Westeneng, Michael A. Van Es, Wouter Van Rheenen, Leonard H. Van Den Berg, Marinus J.C. Eijkemans, Jan H. Veldink
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 2024, vol. 25, p.188-196