Wim Otte

Associate Professor

Strategic program(s):

Biography

Wim Otte is clinical epidemiologist at the UMC Utrecht Brain Center, and specialized in the statistics of predictive modeling research. He advocates open science and Bayesian inference. His recent work is dedicated to epilepsy-related clinical questions with sidesteps in the field of hearing disabilities, meta-research, and philosophy of science.

Strategic program(s):

Contact

wotte@umcutrecht.nl

Pure profile

Research groups

Personalized prediction, treatment and genetics in epilepsy

Research aim

We develop personalized methods for diagnosing, treating, and predicting outcome in epilepsy. Our aim is to better control seizures, treat comorbidities, and improve quality of life with a precision medicine approach in all people with epilepsy.

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Recent publications

All publications

Reliability and state-dependency of EEG connectivity, complexity and network characteristics L. S. Dominicus, D. Y. Lodema, B. Oranje, M. G. Zandstra, A. P.C. Hermans, L. Imhof, W. M. Otte, A. Hillebrand, K. Ambrosen, C. J. Stam, B. H. Ebdrup, E. van Dellen
Scientific Reports, 2025, vol. 15

The use of IPD meta-analysis in maternal health prognostics Willem M Otte
Lancet (London, England), 2025, vol. 406, p.1926-1927

What determines the timing of epilepsy surgery in children with cortical malformations and low-grade epilepsy-associated tumors? Maurits W.C.B. Sanders, Matyas Ebel, Aswin Chari, Merel Fleumer, Anca M. Vasilica, Maria H. Eriksson, Martin Tisdall, Barbora Splitkova, Anezka Belohlavkova, Willem M. Otte, Floor E. Jansen, J. Helen Cross, Kees P.J. Braun, Pavel Krsek
Epilepsia Open, 2025, vol. 10, p.1345-1352

Antiseizure medication reduction in long-term video-electroencephalographic monitoring for presurgical evaluation Renate van Griethuysen, Charlotte J J van Asch, Willem M Otte, Herm Lamberink, Josemir W Sander, Mireille D Bourez-Swart, Lotte de Jong, Albert J Colon, Kees P J Braun,
Epilepsia, 2025, vol. 66, p.4490-4500

Structural and effective brain connectivity in focal epilepsy S. B. Jelsma, M. Zijlmans, I. B. Heijink, F. W.A. Hoefnagels, M. Raemaekers, W. M. Otte, N. E.C. van Klink, D. van Blooijs
Neuroimage: Reports, 2025, vol. 5

Blueprint for clinical N-of-1 strategies with off-label precision treatments in monogenic epilepsies Victoria M Defelippe, Eva H Brilstra, Willem M Otte, Ghislaine J M W van Thiel, Helen J Cross, Finbar O'Callaghan, Valentina De Giorgis, Emilio Perucca, Kees P J Braun, Floor E Jansen
Orphanet Journal of Rare Diseases, 2025, vol. 20

External positions

Dovenpastoraat - Geen, behalve dat door crisispastoraat werktijden mogelijk afgestemd moeten worden - Protestantse Kerk Nederland, Dienstencentrum