Profile photo Wilton van Klei

Wilton van Klei

Full Professor

Strategic program(s):

Biography

Wilton van Klei received his PhD in 2002 and completed his postgraduate training as anesthesiologist in the Netherlands (2006. After that he did a clinical and research fellowship in perioperative medicine (Ottawa, Ontario, 2007). He returned to the Netherlands to complete a fellowship in cardiothoracic anesthesia (2009), including training in TEE. From 2007 till 2012, he was the Medical Director of the Outpatient Preoperative Evaluation Clinic of the UMC Utrecht. Subsequently, he was the Chair of the Department of Anesthesiology and the Director Research and Education of the Division of Anesthesiology, Intensive Care and Emergency Medicine of the UMC Utrecht (2013-2021). Curently, his primary affiliation is at the University Health Network Toronto / University of Toronto, but he holds a small appointment as a research professor at the UMC Utrecht.

 

His interests focus on improving care for high-risk surgical patients, and involve collaborations with cardiologists, surgeons, clinical chemists, and epidemiologists within the UMC Utrecht’s Circulatory Health research programme. He is supervising several PhD students on clinical research projects in the field of cardiovascular perioperative medicine. Most projects aim to unravel further the etiology, detection and treatment of asymptomatic myocardial injury after surgery. He considers hisself a specialist in perioperative medicine.
Perioperative medicine starts before surgery with a preanesthesia assessment and currently often ends with the patient leaving the recovery room, except for a responsibility for postoperative pain management. However, anesthesiologists should be involved not only in pain management, but also in providing postoperative care on general wards, monitoring vital functions and monitoring for complications likely to be related to surgery and anesthesia. In fact, anesthesiologists should extend what they are doing in the operating room to the surgical floor in order to improve patient outcomes. He is working towards this goal by initiating research in those areas where evidence for optimal treatment is absent.

Research groups

Perioperative risk management and monitoring

Research aim

Our research aim is to improve prevention and early detection of complications in surgical patients, in order to reduce morbidity and improve or preserve quality of life, and to develop novel monitoring techniques and advanced AI technology.

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Recent publications

Postoperative myocardial injury phenotypes and self-reported disability in patients undergoing noncardiac surgery Lisette M. Vernooij, Judith A.R. van Waes, Remco B. Grobben, Felix van Lier, Simon Feng, Matthew Machina, Michael McKenny, Hendrik M. Nathoe, Duminda N. Wijeysundera, Wilton A. van Klei, W. Scott Beattie
British Journal of Anaesthesia, 2024
Postoperative troponin surveillance to detect myocardial infarction Selene Martinez-Perez, Judith A.R. van Waes, Lisette M. Vernooij, Brian H. Cuthbertson, W. Scott Beattie, Duminda N. Wijeysundera, Wilton A. van Klei
British Journal of Anaesthesia, 2024, vol. 132, p.667-674
The effect of proactive versus reactive treatment of hypotension on postoperative disability and outcome in surgical patients under anaesthesia (PRETREAT) Matthijs Kant, Wilton A. van Klei, Markus W. Hollmann, Denise P. Veelo, Teus H. Kappen, Eline de Klerk, Lisette M. Vernooij, Luuk C. Otterspoor, Geert Jan E. Cromheecke, Marlous Huijzer, Jannie Witziers, Lotte E. Terwindt, Tim Bastiaanse, Rogier V. Immink, Magnus Strypet, Niek H. Sperna Weiland, Marije Wijnberge, Marc G.H. Besselink, Lisette M. Vernooij, Yvonne C. Janmaat, Annemarie Akkermans,
BJA open, 2024, vol. 9
Effect of a national guideline on postoperative troponin surveillance Eva Alvarez Torres, Justyna Bartoszko, Selene Martinez Perez, Gordon Tait, Michael Santema, W. Scott Beattie, Stuart A. McCluskey, Wilton A. van Klei
Canadian Journal of Anesthesia, 2023, vol. 71, p.322-329
Improved Re-estimation of Perioperative Cardiac Risk Using the Surgical Apgar Score Julian F. Daza, Justyna Bartoszko, Wilton Van Klei, Karim S. Ladha, Stuart A. Mccluskey, Duminda N. Wijeysundera
Annals of surgery, 2023, vol. 278, p.65-71
Systematic reviews and consensus definitions for the Standardised Endpoints in Perioperative Medicine (StEP) initiative Alexander I.R. Jackson, Oliver Boney, Rupert M. Pearse, Andrea Kurz, D. James Cooper, Wilton van Klei, Luca Cabrini, Timothy E. Miller, S. Ramani Moonesinghe, Paul Myles, Michael P.W. Grocott, Paul Myles, T. J. Gan, Phil Peyton, Dan Sessler, Martin Tramèr, Alan Cyna, Gildasio S. De Oliveira, Christopher Wu, Mark Jensen, Henrik Kehlet, Mari Botti, Guy Haller, Mike Grocott, Tim Cook, Lee Fleisher, Mark Neuman, David Story, Russell Gruen, Sam Bampoe, Lis Evered, David Scott, Brendan Silbert, Diederik van Dijk, Cor Kalkman, Matthew Chan, Hilary Grocott, Rod Eckenhoff, Lars Rasmussen, Lars Eriksson, Scott Beattie, Duminda Wijeysundera, Giovanni Landoni, Kate Leslie, Bruce Biccard, Simon Howell, Peter Nagele, Toby Richards, Stefan Dieleman, Wilton van Klei,
British Journal of Anaesthesia, 2023, vol. 130, p.404-411