Profile photo Wilton van Klei

Wilton van Klei

Full Professor

Strategic program(s):

Biography

Wilton van Klei received his PhD in 2002 and completed his postgraduate training as anesthesiologist in the Netherlands (2006. After that he did a clinical and research fellowship in perioperative medicine (Ottawa, Ontario, 2007). He returned to the Netherlands to complete a fellowship in cardiothoracic anesthesia (2009), including training in TEE. From 2007 till 2012, he was the Medical Director of the Outpatient Preoperative Evaluation Clinic of the UMC Utrecht. Subsequently, he was the Chair of the Department of Anesthesiology and the Director Research and Education of the Division of Anesthesiology, Intensive Care and Emergency Medicine of the UMC Utrecht (2013-2021). Curently, his primary affiliation is at the University Health Network Toronto / University of Toronto, but he holds a small appointment as a research professor at the UMC Utrecht.

 

His interests focus on improving care for high-risk surgical patients, and involve collaborations with cardiologists, surgeons, clinical chemists, and epidemiologists within the UMC Utrecht’s Circulatory Health research programme. He is supervising several PhD students on clinical research projects in the field of cardiovascular perioperative medicine. Most projects aim to unravel further the etiology, detection and treatment of asymptomatic myocardial injury after surgery. He considers hisself a specialist in perioperative medicine.
Perioperative medicine starts before surgery with a preanesthesia assessment and currently often ends with the patient leaving the recovery room, except for a responsibility for postoperative pain management. However, anesthesiologists should be involved not only in pain management, but also in providing postoperative care on general wards, monitoring vital functions and monitoring for complications likely to be related to surgery and anesthesia. In fact, anesthesiologists should extend what they are doing in the operating room to the surgical floor in order to improve patient outcomes. He is working towards this goal by initiating research in those areas where evidence for optimal treatment is absent.

Research groups

Perioperative risk management and monitoring

Research aim

Our research aim is to improve prevention and early detection of complications in surgical patients, in order to reduce morbidity and improve or preserve quality of life, and to develop novel monitoring techniques and advanced AI technology.

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Recent publications

Cerebrovascular regulation during increases in systemic blood flow and systemic vascular resistance Emma H.M. Torn, Bas van Zaane, Niels P. van der Kaaij, Lisette M. Vernooij, Jan Folkert Heida, Wilton A. van Klei, Rogier V. Immink
Journal of Applied Physiology, 2025, vol. 139, p.1694-1702
Proactive vs Reactive Treatment of Hypotension During Surgery The PRETREAT Randomized Clinical Trial Matthijs Kant, Wilton A. van Klei, Markus W. Hollmann, Eline S. de Klerk, Luuk C. Otterspoor, Marc G. Besselink, Teus H. Kappen, Denise P. Veelo, , Ronald Zweemer, Jelle Ruurda
JAMA, 2025, vol. 334, p.1905-1914
The association between postoperative myocardial injury of unexplained aetiology after noncardiac surgery and sex and cancer on 1-yr survival Eva P.C. van Schaik, Lisette M. Vernooij, Younes Haddou, Remco B. Grobben, Wilton A. van Klei, Judith A.R. van Waes
BJA open, 2025, vol. 16
Use of prothrombin complex concentrates in liver transplantation Isabella Kojundzic, Neeki Alavi, Austin Lam, Keyvan Karkouti, Jeannie Callum, Matthanja Bieze, Carla Luzzi, Chaya Shwaartz, Marina Englesakis, François Martin Carrier, Jan Willem Boldingh, Jaap Jan Vos, Johannes P. van den Berg, Klaus Görlinger, Christopher Harle, Adrienne Carr, Ton Lisman, Wilton A. van Klei, Stuart A. McCluskey, Justyna Bartoszko
British Journal of Anaesthesia, 2025, vol. 135, p.1172-1192
Blood transfusion and acute kidney injury after cardiac surgery Yuliya Boyko, Sebastian B. Rasmussen, Justyna Bartoszko, Wilton A. van Klei, Stuart McCluskey, Keyvan Karkouti, Hanne B. Ravn
Canadian Journal of Anesthesia, 2025, vol. 72, p.1534-1543
Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in the perioperative period Lynn A Miggelbrink, Wilton A van Klei, Marianne C Verhaar, Folkert W Asselbergs, Wilko Spiering, Wolfgang F F A Buhre, Markus W Hollmann, Felix van Lier, Eric H P A van Dongen, Patrick Schober, Thijs C D Rettig, Hans J B Reitsma, Eva P C van Schaik, Lisette M Vernooij, Judith A R van Waes
British Journal of Anaesthesia, 2025, vol. 135, p.1075-1077

Fellowships & Awards

2011 Research Award of the International Anesthesia Research Society (IARS)