Profile photo Paco Welsing

Paco Welsing

Associate Professor

Biography

I am a clinical Epidemiologist and HTA researcher. My research focuses on the optimal application of health interventions in daily clinical practice with a focus on rheumatic and immunologic diseases, mainly Rheumatoid Arthritis (RA) and Osteoarthritis (OA). More stratified approaches to treatment and the measurement of these treatment effects have been studied in different project, acting as project member/methodologist or (WP) lead. Examples are the CTMM TRACER project focussing on the clinical and health-economic evaluation of personalized approached to diagnosis and treatment of RA, the IMI APPROACH project focussing on exploring phenotypes of osteoarthritis for stratified treatment approaches, the IMI GetReal project focusing on the use of ‘Real World’ data in drug evaluation, specifically focussing on pragmatic trial design and using data from routine practice in trials, the multicenter PATIO trial evaluating a prediction based decision aid tool for tapering biological drugs in RA, the nationwide RCT and cohort study, GODIVA, regarding the (cost-)effectiveness and optimal patient group for joint distraction in young patients with severe knee OA and the EU STRATA-FIT project focussing on difficult-to-treat RA and the development of a stratified treatment approach and decision aid using real world. As the full effects of a treatment strategy when applied in clinical practice are of interest my research naturally includes modelling the clinical effectiveness as well as cost-effectiveness on the long term. I enjoy applying/adapting state-of the art statistical and Machine Learning methods in an innovative and creative way to clinical research questions also working as a methodologist consultant for our division.

Research groups

Rheumatology & clinical immunology

Research aim

To improve clinical practice by optimizing diagnosis, prognosis and treatment of rheumatic and immune-mediated and immune-deficient inflammatory diseases
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Knee joint preserving treatments

Research aim

The main goal of our research group is to develop and test joint preserving treatments for the knee joint, for pathology ranging from cartilage lesions to endstage osteoarthritis
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Recent publications

House dust mite sublingual allergen immunotherapy tablet is safe and well-tolerated in Dutch clinical practice Žana Tempels-Pavlica, Mark C J Aarts, Paco M J Welsing, Akke-Nynke van der Meer, Leonard P van der Zwan, Elena Uss, André C Knulst
Frontiers in allergy, 2024, vol. 5
Machine-learning predicted and actual 2-year structural progression in the IMI-APPROACH cohort Mylène P. Jansen, Wolfgang Wirth, Jaume Bacardit, Eefje M. van Helvoort, Anne C.A. Marijnissen, Margreet Kloppenburg, Francisco J. Blanco, Ida K. Haugen, Francis Berenbaum, Cristoph H. Ladel, Marieke Loef, Floris P.J.G. Lafeber, Paco M. Welsing, Simon C. Mastbergen, Frank W. Roemer
Quantitative Imaging in Medicine and Surgery, 2023, vol. 13, p.3298-3306
Endoscopic ultrasonography-guided gastroenterostomy versus surgical gastrojejunostomy for palliation of malignant gastric outlet obstruction (ENDURO) Janine B Kastelijn, Yorick L van de Pavert, Marc G Besselink, Paul Fockens, Rogier P Voermans, Roy L J van Wanrooij, Thomas R de Wijkerslooth, Wouter L Curvers, Ignace H J T de Hingh, Marco J Bruno, Bas Groot Koerkamp, Gijs A Patijn, Alexander C Poen, Jeanin E van Hooft, Akin Inderson, J Sven D Mieog, Jan-Werner Poley, Alderina Bijlsma, Daan J Lips, Niels G Venneman, Robert C Verdonk, Hendrik M van Dullemen, Frederik J H Hoogwater, Geert W J Frederix, I Quintus Molenaar, Paco M J Welsing, Leon M G Moons, Hjalmar C van Santvoort, Frank P Vleggaar,
Trials, 2023, vol. 24
Identifying multivariate disease trajectories and potential phenotypes of early knee osteoarthritis in the CHECK cohort Sara Altamirano, Mylène P. Jansen, Daniel L. Oberski, Marinus J.C. Eijkemans, Simon C. Mastbergen, Floris P.J.G. Lafeber, Willem E. van Spil, Paco M.J. Welsing
PLoS ONE, 2023, vol. 18
Healthcare Costs and Health-Related Quality of Life in Older Multimorbid Patients After Hospitalization Paola Salari, Séverine Henrard, Cian O’Mahony, Paco Welsing, Arjun Bhadhuri, Katharina Tabea Jungo, Thomas Beck, Denis O’Mahony, Stephen Byrne, Anne Spinewine, Wilma Knol, Nicolas Rodondi, Matthias Schwenkglenks
Health services insights, 2023, vol. 16
Prognostication of progressive pulmonary fibrosis in connective tissue disease-associated interstitial lung diseases Yu Hsiang Chiu, Maaike F.M. Koops, Mareye Voortman, H. Wouter van Es, Lucianne C.M. Langezaal, Paco M.J. Welsing, Anna Jamnitski, Anne E. Wind, Jacob M. van Laar, Jan C. Grutters, Julia Spierings
Frontiers in medicine, 2023, vol. 10