Victor Peperzak

Associate Professor

Strategic program(s):

Contact

vpeperza@umcutrecht.nl

Pure profile

Research groups

B cell malignancies

Research aim

Our research aim is to control cellular life and death decisions to improve treatment of B cell cancers and allow T cell immunotherapy for untreatable cancers.

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Pediatric immunology team

Research aim

The pediatric immunology team focuses on the under-explored research field of immune response modification for the prevention of immune-driven diseases. The goal of our research is to develop interventions that can prevent disease manifestations.

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Recent publications

All publications

Identifying clinical response to daratumumab therapy in relapsed/refractory multiple myeloma using a patient-derived in vitro model Niels van Nieuwenhuijzen, Marta Cuenca, Leonie Abbink, Margot Jak, Victor Peperzak, Monique C Minnema
EJHaem, 2024, vol. 5, p.141-146

Bridging the gap between scientific discoveries and clinical application at the Utrecht Science Park Victor Peperzak, Jonathan M. Coquet
Immunology and Cell Biology, 2024, vol. 102, p.232-234

Nivolumab plus Brentuximab vedotin +/- bendamustine combination therapy Patrick Greve, Auke Beishuizen, Melanie Hagleitner, Jan Loeffen, Margreet Veening, Marianne Boes, Victor Peperzak, Claudius Diez, Friederike Meyer-Wentrup
Frontiers in Immunology, 2023, vol. 14

Serpin B9 controls tumor cell killing by CAR T cells Thomas Kimman, Anne Slomp, Anne Martens, Sarah Grabherr, Shuang Li, Eline van Diest, Jan Meeldijk, Jurgen Kuball, Monique C. Minnema, Eric Eldering, Niels Bovenschen, Zsolt Sebestyén, Victor Peperzak
Journal for ImmunoTherapy of Cancer, 2023, vol. 11

Wnt inhibitors reduce the unfolded protein response and enhance bortezomib-induced cell death in multiple myeloma Ingrid Spaan, Niels van Nieuwenhuijzen, Thomas Kimman, Dedeke Rockx-Brouwer, Ralph G Tieland, Madelon Maurice, Monique C Minnema, Reinier Raymakers, Victor Peperzak
Blood Advances, 2022, vol. 7, p.1103-1107

Advances and Perspectives in the Treatment of B-Cell Malignancies Victor Peperzak, Marta Cuenca Lopera
Cancers, 2021, vol. 13

Fellowships & Awards

2020: KWF/Alpe d'HuZes Research Project grant: Optimized Killing (OK) technology to empower engineered T or NK cells in the treatment of cancer.

2019: Targeting V-D-J recombined B-cell receptors as neoantigens for lymphoma immunotherapy

2018: Dutch Cancer Society/KWF Unique High Risk Project: Empowering the T cell killing machinery to eradicate cancer cells and prevent outgrowth.

2017: Dutch Cancer Society/KWF Research Project: Personalized strategy to avert drug resistance in hematologic cancers.

2015: Dutch Cancer Society/KWF personal Bas Mulder Award: Towards therapeutic targeting of Myeloid cell leukemia 1 (MCL-1) in B cell cancers.

2013: NWO-VENI personal Research Grant: Controlling death; regulation of MCL-1 in lymphocytes and lymphoma cells.

2011: EMBO Long-Term Fellowship

2010: Multiple Myeloma Research Foundation (MMRF) Research Fellow Award