Jacco van Rheenen

Full Professor

Strategic program(s):

Contact

jrheenen@umcutrecht.nl

Pure profile

Recent publications

All publications

Intestinal tuft cell subtypes represent successive stages of maturation driven by crypt-villus signaling gradients Julian R Buissant des Amorie, Max A Betjes, Jochem H Bernink, Joris H Hageman, Veerle E Geurts, Harry Begthel, Dimitrios Laskaris, Maria C Heinz, Ingrid Jordens, Tiba Vinck, Ronja M Houtekamer, Ingrid Verlaan-Klink, Sascha R Brunner, Jacco van Rheenen, Martijn Gloerich, Hans Clevers, Sander J Tans, Jeroen S van Zon, Hugo J G Snippert
Nature Communications, 2025, vol. 16

The oestrous cycle stage affects mammary tumour sensitivity to chemotherapy Laura Bornes, Lennart J. van Winden, Veerle C.M. Geurts, Beaunelle de Bruijn, Leyla Azarang, Mirthe Lanfermeijer, Marika Caruso, Natalie Proost, Manon Boeije, Jeroen O. Lohuis, Guillaume Belthier, Eulàlia Noguera Delgado, Nadia de Gruil, Judith R. Kroep, Marieke van de Ven, Renee Menezes, Jelle Wesseling, Marleen Kok, Sabine Linn, Annegien Broeks, Huub H. van Rossum, Colinda L.G.J. Scheele, Jacco van Rheenen
Nature, 2024, vol. 637, p.195-204

Mechanisms that clear mutations drive field cancerization in mammary tissue Marta Ciwinska, Hendrik A. Messal, Hristina R. Hristova, Catrin Lutz, Laura Bornes, Theofilos Chalkiadakis, Rolf Harkes, Nathalia S.M. Langedijk, Stefan J. Hutten, Renée X. Menezes, Jos Jonkers, Stefan Prekovic, Marja van Oirsouw, Ellen Verschuur, Donna Pinto, Deborah Collyar, Hilary Stobart, Proteeti Bhattacharjee, Daniel Rea, Lodewyk F.A. Wessels, Marjanka Schmidt, Esther H. Lips, Fariba Behbod, Jacco van Rheenen, Jos Jonkers, E. Shelley Hwang, Nicholas E. Navin, Andrew Futreal, Helen R. Davies, Elinor J. Sawyer, Serena Nik-Zainal, Alastair M. Thompson, Jelle Wesseling, Benjamin D. Simons, Colinda L.G.J. Scheele,
Nature, 2024, vol. 633, p.198-206

Predictive gene expression profile for adjuvant taxane benefit in breast cancer in the MATADOR trial Mark Opdam, Annelot G.J. van Rossum, Marlous Hoogstraat, Gergana Bounova, Hugo M. Horlings, Erik van Werkhoven, Ingrid A.M. Mandjes, A. Elise van Leeuwen – Stok, Sander Canisius, Harm van Tinteren, Alex L.T. Imholz, Johanneke E.A. Portielje, Monique E.M.M. Bos, Sandra Bakker, Jelle Wesseling, Lennart Kester, Jacco van Rheenen, Emiel J. Rutgers, Renee X. de Menezes, Lodewyk F.A. Wessels, Marleen Kok, Hendrika M. Oosterkamp, Sabine C. Linn, Marcel Soesan, Rianne M. Oosterkamp, Frank Jeurissen, Nir Weijl, Karin J. Beelen, Aart van Bochove, Gerty de Klerk, Suzan Vrijaldenhoven, Annette van der Velden, Hiltje de Graaf, Marielle Smeets, Jetske Meerum Terwogt, Jolanda Schrama, Philomeen Kuijer, Hanneke Wilmink, Ronald Hoekstra, Judith Kroep, Hans F.M. Pruijt, Leander van Gerven, Allert H. Vos, Frans Erdkamp, Willemien G. van Leeuwen-Breuk, Alexander de Graeff,
iScience, 2024, vol. 27

Tumour microenvironment characterisation to stratify patients for hyperthermic intraperitoneal chemotherapy in high-grade serous ovarian cancer (OVHIPEC-1) S Lot Aronson, Cédric Walker, Bram Thijssen, Koen K van de Vijver, Hugo M Horlings, Joyce Sanders, Maartje Alkemade, Simone N Koole, Marta Lopez-Yurda, Christianne A R Lok, Sven Rottenberg, Jacco van Rheenen, Gabe S Sonke, Willemien J van Driel, Lennart A Kester, Kerstin Hahn, , Henk Schreuder
British Journal of Cancer, 2024, vol. 131, p.565-576

Taxanes trigger cancer cell killing in vivo by inducing non-canonical T cell cytotoxicity Claire Vennin, Chiara M. Cattaneo, Leontien Bosch, Serena Vegna, Xuhui Ma, Hugo G.J. Damstra, Moreno Martinovic, Efi Tsouri, Mila Ilic, Leyla Azarang, Jan R.T. van Weering, Emilia Pulver, Amber L. Zeeman, Tim Schelfhorst, Jeroen O. Lohuis, Anne C. Rios, Johanna F. Dekkers, Leila Akkari, Renee Menezes, Rene Medema, Serena R. Baglio, Anna Akhmanova, Sabine C. Linn, Simone Lemeer, Dirk M. Pegtel, Emile E. Voest, Jacco van Rheenen
Cancer Cell, 2023, vol. 41, p.1170-1185.e12

Fellowships & Awards

2015 Awarded an ERC consolidator grant by the European Research Council

2013 Stem Cells Young Investigator Award 2013 (10,000 dollar personal money)

2008 Awarded a VIDI grant by the Netherlands Organisation for Scientific Research (NWO).

2006 Fellowship for fundamental and (pre-)clinical cancer research from the Dutch Cancer Society (KWF).