Profile photo Joris van Montfrans

Joris van Montfrans

Assistant Professor - medical

Strategic program(s):

Biography

Dr. Joris van Montfrans is an Associate Professor of Pediatric Immunology in the UMC Utrecht. He completed his medical study at the Rijks Universiteit Leiden and his PhD at the Vrije Universiteit Amsterdam. He performed his pediatric training at the UMC Utrecht and at Tygerberg Hospital in Cape Town, South Africa. He is a consultant in pediatric immunology since 2009. Dr. van Montfrans works as a clinical doctor and as a researcher in the field of primary immunodeficiencies. He is currently the head of the combined departments of pediatric immunology, -infectious diseases, -rheumatology and -hematology. The research areas he is involved in include genetic causes of primary immune deficiencies and long term complications of antibody deficiencies. He is the principal investigator for a national study assessing efficacy of early screening for genetic causes of immunodeficiencies. He is also the principal investigator in a study into auto-immune complications in CVID, and recently started a national RCT exploring the optimal dose of IgRT in CVID patients. He is secretary of the National Working Party for Immunodeficiencies and member of the eGLILD consortium steering committee. He is an active teacher involved in of training medical students and as such he is involved organizing EUREKA summer schools.

Research groups

Pediatric immunology team

Research aim

The pediatric immunology team focuses on the under-explored research field of immune response modification for the prevention of immune-driven diseases. The goal of our research is to develop interventions that can prevent disease manifestations.
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Primary immunodeficiency

Research aim

To address unmet medical needs by detecting novel primary immunodeficiency, and improving clinical practice by optimizing diagnosis, prognosis and treatment of disease.
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Recent publications

JAK inhibitor treatment for inborn errors of JAK/STAT signaling Marco Fischer, Peter Olbrich, Jérôme Hadjadj, Volker Aumann, Shahrzad Bakhtiar, Vincent Barlogis, Philipp von Bismarck, Markéta Bloomfield, Claire Booth, Emmeline P. Buddingh, Deniz Cagdas, Martin Castelle, Alice Y. Chan, Shanmuganathan Chandrakasan, Kritika Chetty, Pierre Cougoul, Etienne Crickx, Jasmeen Dara, Angela Deyà-Martínez, Susan Farmand, Renata Formankova, Andrew R. Gennery, Luis Ignacio Gonzalez-Granado, David Hagin, Leif Gunnar Hanitsch, Jana Hanzlikovà, Fabian Hauck, José Ivorra-Cortés, Kai Kisand, Ayca Kiykim, Julia Körholz, Timothy Ronan Leahy, Joris van Montfrans, Zohreh Nademi, Brigitte Nelken, Suhag Parikh, Silvi Plado, Jan Ramakers, Antje Redlich, Frédéric Rieux-Laucat, Jacques G. Rivière, Yulia Rodina, Pérsio Roxo Júnior, Sarah Salou, Catharina Schuetz, Anna Shcherbina, Mary A. Slatter, Fabien Touzot, Ekrem Unal, Arjan C. Lankester, Siobhan Burns, Mikko R.J. Seppänen, Olaf Neth, Michael H. Albert, Stephan Ehl, Bénédicte Neven, Carsten Speckmann
Journal of Allergy and Clinical Immunology, 2024, vol. 153, p.275-286.e18
Wiskott-Aldrich syndrome Tanja C. Vallée, Jannik S. Glasmacher, Hannes Buchner, Peter D. Arkwright, Uta Behrends, Anastasia Bondarenko, Michael J. Browning, David Buchbinder, Alessandro Cattoni, Liudmyla Chernyshova, Peter Ciznar, Theresa Cole, Wojciech Czogała, Gregor Dueckers, John David M. Edgar, Fatih Erbey, Anders Fasth, Francesca Ferrua, Renata Formankova, Eleonora Gambineri, Andrew R. Gennery, Frederick D. Goldman, Luis I. Gonzalez-Granado, Carsten Heilmann, Tarja Heiskanen-Kosma, Hanna Juntti, Leena Kainulainen, Hirokazu Kanegane, Neslihan E. Karaca, Sara S. Kilic, Christoph Klein, Sylwia Kołtan, Irina Kondratenko, Isabelle Meyts, Gulnara M. Nasrullayeva, Lucia D. Notarangelo, Srdjan Pasic, Isabelle Pellier, Claudio Pignata, Siraj Misbah, Ansgar Schulz, Gesmar R. Segundo, Anna Shcherbina, Mary Slatter, Robert Sokolic, Pere Soler-Palacin, Polina Stepensky, Joris M. van Montfrans, Samppa Ryhänen, Beata Wolska-Kuśnierz, John B. Ziegler, Xiaodong Zhao, Alessandro Aiuti, Hans D. Ochs, Michael H. Albert
Blood, 2024, vol. 143, p.2504-2516
Humoral and cellular immunogenicity, effectiveness and safety of COVID-19 mRNA vaccination in patients with pediatric rheumatic diseases Mohamad Hamad Saied, Joeri W van Straalen, Sytze de Roock, Frans M Verduyn Lunel, Jelle de Wit, Lia G H de Rond, Erika Van Nieuwenhove, Bas J Vastert, Joris M van Montfrans, Annet van Royen-Kerkhof, Gerrie C J de Joode-Smink, Joost F Swart, Nico M Wulffraat, Marc H A Jansen
Vaccine, 2024, vol. 42, p.1145-1153
Pulmonary Computed Tomography Screening Frequency in Primary Antibody Deficiency Bas M Smits, Sharisa L Boland, Marjolein E Hol, Rana Dandis, Helen Leavis, Pim A de Jong, Sabine M P J Prevaes, Firdaus A A Mohamed Hoesein, Joris M van Montfrans, Pauline M Ellerbroek
Journal of Allergy and Clinical Immunology: In Practice, 2024, vol. 12, p.1037-1048.e3
Comprehensive reanalysis for CNVs in ES data from unsolved rare disease cases results in new diagnoses German Demidov, Burcu Yaldiz, José Garcia-Pelaez, Elke de Boer, Nika Schuermans, Liedewei Van de Vondel, Ida Paramonov, Lennart F. Johansson, Francesco Musacchia, Elisa Benetti, Gemma Bullich, Karolis Sablauskas, Sergi Beltran, Christian Gilissen, Alexander Hoischen, Stephan Ossowski, Richarda de Voer, Katja Lohmann, Carla Oliveira, Ana Topf, Lisenka E.L.M. Vissers, Kristina Zguro, Federico Zara, Ioannis Zaganas, Vicente A. Yépez, Brunhilde Wirth, David Webb, Hannah Verdin, Erika Van Nieuwenhove, Joris van Montfrans, Roxane van Heurck, Lars van der Veken, Laura Valle, Paolo Uva, Bjarne Udd, Aurelien Trimouille, Rachel Thompson, Marco Tartaglia, Yves Sznajer, Pasquale Striano, Verena Steinke-Lange, Martha Spilioti, Paolo Scudieri, Evelin Schröck, Katherine Schon, Marcello Scala, Helen Leavis, Manon Huibers, Marielle van Gijn, Geert de Vries, , Steven Laurie
npj Genomic Medicine, 2024, vol. 9
Impact of newborn screening for SCID on the management of congenital athymia Evey Howley, Zainab Golwala, Matthew Buckland, Federica Barzaghi, Sujal Ghosh, Scott Hackett, Rosie Hague, Fabian Hauck, Ursula Holzer, Adam Klocperk, Minna Koskenvuo, Nufar Marcus, Antonio Marzollo, Malgorzata Pac, Jan Sinclair, Carsten Speckmann, Maarja Soomann, Lynne Speirs, Sneha Suresh, Sophie Taque, Joris van Montfrans, Horst von Bernuth, Brynn K. Wainstein, Austen Worth, E. Graham Davies, Alexandra Y. Kreins
Journal of Allergy and Clinical Immunology, 2023, vol. 153, p.330-334

Fellowships & Awards

2020: Jeffrey Modell Foundation C.H.I.L.D.R.E.N! Research Program grant