Profile photo Linda van Laake

Linda van Laake

Full Professor

Biography

Linda W. Van Laake, MD, PhD obtained her medical degree at Maastricht University and her PhD (title: Cardiac Recovery by Stem and Progenitor Cells) at Utrecht University, after which she continued her scientific career as a postdoctoral researcher at the Gladstone Institutes, University of California, San Francisco (USA). In 2011 she became Assistant Professor at the Department of Cardiology of the University Medical Center Utrecht and the Hubrecht Institute Utrecht, the Netherlands. In addition, she works as a clinical cardiologist specialized in heart failure.

Dr. Van Laake’s team explores novel approaches to regenerate the heart using stem- and progenitor cells. Many cardiovascular diseases, such as heart failure and myocardial infarction, are associated with loss of functional cardiomyocytes (heart muscle cells). A focus on the understanding of fundamental cardiac developmental – and repair processes will promote the recapitulation of cardiac differentiation in vitro. Currently, the team is investigating the influence of circadian or “day-night” rhythms on cardiac development and regeneration.

Combing a variety of novel approaches together with a greater understanding of how heart development and repair work, Dr. Van Laake and her team strive to create better personalized heart failure therapies.

 

Research groups

Inherited heart disease (cardiogenetics)

Research aim

We aim to enhance patient and family lives impacted by inherited cardiomyopathies. Our efforts target gene and variant identification, disease mechanisms, factors influencing disease outcomes, therapy optimization, and exploration of novel therapies.
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Cardiac repair and regeneration

Research aim

Current available therapies for chronic heart diseases only alleviate symptoms and prevent the disease from becoming worse. We aim to improve our understanding and stimulate our natural potential for myocardial repair.
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Molecular science & therapy in heart failure

Research aim

Current available therapies for chronic heart diseases only alleviate symptoms and prevent the disease from becoming worse. We aim to improve our understanding of heart failure and develop new strategies for therapy.
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Recent publications

Healthcare consumption of patients with left ventricular assist device Lena Bosch, Peter-Paul M Zwetsloot, Maaike Brons, Gerardus P J van Hout, Manon G van der Meer, Mariusz K Szymanski, Anne-Marie Troost-Oppelaar, Faiz Z Ramjankhan, Pim van der Harst, Monica Gianoli, Marish I F J Oerlemans, Linda W van Laake
Netherlands Heart Journal, 2024, vol. 32, p.317-325
Mechanisms of myocardial reverse remodelling and its clinical significance Inês Falcão-Pires, Ana Filipa Ferreira, Fábio Trindade, Luc Bertrand, Michele Ciccarelli, Valeria Visco, Dana Dawson, Nazha Hamdani, Linda W. Van Laake, Frank Lezoualc'h, Wolfgang A. Linke, Ida G. Lunde, Peter P. Rainer, Mahmoud Abdellatif, Jolanda Van der Velden, Nicola Cosentino, Alessia Paldino, Giulio Pompilio, Serena Zacchigna, Stephane Heymans, Thomas Thum, Carlo Gabriele Tocchetti
European Journal of Heart Failure, 2024, vol. 26, p.1454-1479
Impairments identified by comprehensive geriatric assessment in potential candidates for left ventricular assist device and heart transplantation Lauren Dautzenberg, Linda W. van Laake, Renee C.M.A. Raijman, Geert J. Lefeber, Wilma Knol, Marish I.F. Oerlemans, Faiz Z. Ramjankhan, Susan A. Braithwaite, Mieke D.J. Nagtegaal, Marielle H. Emmelot-Vonk, Huiberdina L. Koek
IJC Heart and Vasculature, 2024, vol. 50
Integration of circadian rhythms and immunotherapy for enhanced precision in brain cancer treatment Matthias Quist, Maas van Os, Linda W. van Laake, Niels Bovenschen, Sandra Crnko
EBioMedicine, 2024, vol. 109
ECPELLA as a bridge-to-decision in refractory cardiogenic shock Jan Willem Balder, Mariusz K. Szymanski, Linda W. van Laake, Pim van der Harst, Christiaan L. Meuwese, Faiz Z. Ramjankhan, Manon G. van der Meer, Jeannine A.J.M. Hermens, Michiel Voskuil, Eric E.C. de Waal, Dirk W. Donker, Marish I.F.J. Oerlemans, Adriaan O. Kraaijeveld
Netherlands Heart Journal, 2024, vol. 32, p.245-253
Soluble Suppression of Tumorigenicity-2 Predicts Mortality and Right Heart Failure in Patients With a Left Ventricular Assist Device Lieke Numan, Emmeke Aarts, Faiz Ramjankhan, Marish I.F. Oerlemans, Manon G. van der Meer, Nicolaas de Jonge, Anne Marie Oppelaar, Hans Kemperman, Folkert W. Asselbergs, Linda W. Van Laake
Journal of the American Heart Association, 2024, vol. 13

External positions

Bestuurslid Werkgroep Hartfalen - Connectie beroepsgroep (cardiologen) - hartfalen, o.a. scholing, beoordelen beleidsdocumenten - NVVC

Commissielid Dekkerbeurzen (clinical scientist en postdoc) - Beursaanvragen beoordelen en selecteren - Hartstichting