Trudy Straetemans

Associate Professor

Strategic program(s):

Contact

gstraete@umcutrecht.nl

Pure profile

Research groups

Tumor Immunology

Research aim

Our research aims to revolutionise cancer treatment by advancing innovative immunotherapies, ensuring safer, more effective therapies, and improving patient outcomes, ultimately transforming lives through cutting-edge translational cancer research.

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Recent publications

All publications

Basics of advanced therapy medicinal product development in academic pharma and the role of a GMP simulation unit I. Johanna, A. Daudeij, F. Devina, C. Nijenhuis, B. Nuijen, B. Romberg, C. de Haar, J. Haanen, H. Dolstra, E. Bremer, Z. Sebestyen, T. Straetemans, I. Jedema, J. Kuball
Immuno-Oncology and Technology, 2023, vol. 20

Strategies to improve γδTCRs engineered T-cell therapies for the treatment of solid malignancies A D Meringa, P Hernández-López, A Cleven, M de Witte, T Straetemans, J Kuball, D X Beringer, Z Sebestyen
Frontiers in Immunology, 2023, vol. 14, p.1-7

Dual targeting of cancer metabolome and stress antigens affects transcriptomic heterogeneity and efficacy of engineered T cells Patricia Hernández-López, Eline van Diest, Peter Brazda, Sabine Heijhuurs, Angelo Meringa, Lauren Hoorens van Heyningen, Caterina Riillo, Caroline Schwenzel, Marina Zintchenko, Inez Johanna, Mara J T Nicolasen, Astrid Cleven, Thomas A Kluiver, Rosemary Millen, Jiali Zheng, Froso Karaiskaki, Trudy Straetemans, Hans Clevers, Remco de Bree, Hendrik G Stunnenberg, Weng Chuan Peng, Jeanine Roodhart, Susana Minguet, Zsolt Sebestyén, Dennis X Beringer, Jürgen Kuball
Nature immunology, 2023, vol. 25, p.88-101

The Role of γδ T Cells as a Line of Defense in Viral Infections after Allogeneic Stem Cell Transplantation Anke Janssen, Eline van Diest, Anna Vyborova, Lenneke Schrier, Anke Bruns, Zsolt Sebestyen, Trudy Straetemans, Moniek de Witte, Jürgen Kuball
Viruses, 2022, vol. 14, p.1-15

Uncovering the mode of action of engineered T cells in patient cancer organoids Johanna F. Dekkers, Maria Alieva, Astrid Cleven, Farid Keramati, Amber K.L. Wezenaar, Esmée J. van Vliet, Jens Puschhof, Peter Brazda, Inez Johanna, Angelo D. Meringa, Heggert G. Rebel, Maj Britt Buchholz, Mario Barrera Román, Amber L. Zeeman, Sam de Blank, Domenico Fasci, Maarten H. Geurts, Annelisa M. Cornel, Else Driehuis, Rosemary Millen, Trudy Straetemans, Mara J.T. Nicolasen, Tineke Aarts-Riemens, Hendrikus C.R. Ariese, Hannah R. Johnson, Ravian L. van Ineveld, Froso Karaiskaki, Oded Kopper, Yotam E. Bar-Ephraim, Kai Kretzschmar, Alexander M.M. Eggermont, Stefan Nierkens, Ellen J. Wehrens, Henk G. Stunnenberg, Hans Clevers, Jürgen Kuball, Zsolt Sebestyen, Anne C. Rios
Nature Biotechnology, 2022, vol. 41, p.60-69

γ9δ2 T-Cell Expansion and Phenotypic Profile Are Reflected in the CDR3δ Repertoire of Healthy Adults Anna Vyborova, Anke Janssen, Lucrezia Gatti, Froso Karaiskaki, Austin Yonika, Sanne van Dooremalen, Jasper Sanders, Dennis X Beringer, Trudy Straetemans, Zsolt Sebestyen, Jürgen Kuball
Frontiers in Immunology, 2022, vol. 13, p.1-13