Ton Logtenberg

Full Professor

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Recent publications

Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR x LGR5 bispecific antibody with efficacy in epithelial tumors Bram Herpers, Berina Eppink, Mark I. James, Carme Cortina, Adrià Cañellas-Socias, Sylvia F. Boj, Xavier Hernando-Momblona, Dominik Glodzik, Rob C. Roovers, Marc van de Wetering, Carina Bartelink-Clements, Vanessa Zondag-van der Zande, Jara García Mateos, Kuan Yan, Lucia Salinaro, Abdul Basmeleh, Szabolcs Fatrai, David Maussang, Jeroen J. Lammerts van Bueren, Irene Chicote, Garazi Serna, Laia Cabellos, Lorena Ramírez, Paolo Nuciforo, Ramon Salazar, Cristina Santos, Alberto Villanueva, Camille Stephan-Otto Attolini, Elena Sancho, Hector G. Palmer, Josep Tabernero, Michael R. Stratton, John de Kruif, Ton Logtenberg, Hans Clevers, Leo S. Price, Robert G.J. Vries, Eduard Batlle, Mark Throsby
Nature Cancer, 2022, vol. 3, p.418-436

MCLA-117, a CLEC12AxCD3 bispecific antibody targeting a leukaemic stem cell antigen, induces T cell-mediated AML blast lysis Pieter Fokko van Loo, Basav N. Hangalapura, Soley Thordardottir, John D. Gibbins, Henrike Veninga, Linda J.A. Hendriks, Arjen Kramer, Rob C. Roovers, Marij Leenders, John de Kruif, Robert P. Doornbos, Andres Sirulnik, Mark Throsby, Ton Logtenberg, Harry Dolstra, Alexander B.H. Bakker
Expert Opinion on Biological Therapy, 2019, vol. 19, p.721-733

Unbiased Combinatorial Screening Identifies a Bispecific IgG1 that Potently Inhibits HER3 Signaling via HER2-Guided Ligand Blockade Cecile A.W. Geuijen, Camilla De Nardis, David Maussang, Eric Rovers, Tristan Gallenne, Linda J.A. Hendriks, Therese Visser, Roy Nijhuis, Ton Logtenberg, John de Kruif, Piet Gros, Mark Throsby
Cancer Cell, 2018, vol. 33, p.922-936.e10

Generation of stable cell clones expressing mixtures of human antibodies John De Kruif, Arjen Kramer, Roy Nijhuis, Vanessa Van Der Zande, Renate Den Blanken, Carina Clements, Therèse Visser, Rob Keehnen, Marcel Den Hartog, Mark Throsby, Ton Logtenberg
Biotechnology and Bioengineering, 2010, vol. 106, p.741-750

Human Immunoglobulin Repertoires against Tetanus Toxoid Contain a Large and Diverse Fraction of High-Affinity Promiscuous V_H Genes John de Kruif, Arjen Kramer, Therèse Visser, Carina Clements, Roy Nijhuis, Freek Cox, Vanessa van der Zande, Renate Smit, Daniel Pinto, Mark Throsby, Ton Logtenberg
Journal of Molecular Biology, 2009, vol. 387, p.548-558

Antibody cocktails Ton Logtenberg
Trends in biotechnology, 2007, vol. 25, p.390-394