Profile photo Tolboom

Tolboom

Assistant Professor - medical

Strategic program(s):

Biography

Nuclear medicine physician,
Department of Radiology and Nuclear Medicine, University Medical Centre Utrecht and Princess Maxima Centre for pediatric oncology, Utrecht (fixed term).

Specific clinical fields of interest:
Nuclear Neuro-imaging (i.e. neuro-oncology, epilepsy, neurodegeneration), Pediatric nuclear imaging, Hemato-oncology, Head and Neck oncology, Nuclear therapies (theranostics)

Research line: 
Clinical neuro imaging (co-PI of multicenter study using FET PET for management of glioblastoma, local PI of multicenter TAU PET study investigating clinical value of TAU PET in neurodegeneration), national PI for an European Organization for Research and Treatment of Cancer (EORTC) initiated nuclear treatment study in Meningioma (‘LUMEN’ study). Experimental neuroimaging using neuroinflammation tracers (PI of multi-center study using neuroinflammation PET).

Leadership:
-Member and vice chair of EORTC Brain tumour group/ nuclear medicine committee.
-Member of Neuroimaging committee, European Association of Nuclear Medicine (EANM)
-EANM representative for the European Academy of Neurology (EAN), member of management group of EAN scientific panel on neuroimaging.
-EANM liaison person to the EAN Brain Health Summit initiative.
-Co-Chair of Dutch Society for Nuclear Medicine Neuroimaging committee.

Research groups

Nuclear theranostics research

Research aim

With nuclear theranostics we aim to develop radiopharmaceuticals to improve the disease diagnosis and therapy, including clinical translation for direct impact. Disease areas of interest are (childhood) cancer, neurology and infectious diseases.

Go to group

Clinical and translational neuro-oncology

Research aim

We aim to improve treatments and clinical outcomes of patients with gliomas and other brain tumors, by combining expertise from oncobiology, neuropsychology, imaging, surgical & clinical neurology, and palliative care.

Go to group

Recent publications

Whole-Body [18F]DPA-714 Kinetic Assessment Using PET/CT Scanner with Long Axial Field of View Xavier Palard-Novello, Denise Visser, Maqsood Yaqub, Elsmarieke van de Giessen, Marijke E. den Hollander, Albert D. Windhorst, Sander C.J. Verfaillie, Hans Knoop, Bart N.M. van Berckel, Sandeep S.V. Golla, Nelleke Tolboom, Ronald Boellaard
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2025, vol. 66, p.1142-1148
Update to the RANO working group and EANO recommendations for the clinical use of PET imaging in gliomas Norbert Galldiks, Philipp Lohmann, Mariam Aboian, Ramon F Barajas, William G Breen, Jana Ivanidze, Derek R Johnson, Timothy J Kaufmann, Michelle M Kim, Maximilian J Mair, Giuseppe Minniti, Michael Müther, Ali Nabavizadeh, Joshua D Palmer, Roberta Rudà, Marion Smits, Nelleke Tolboom, Sophie E M Veldhuijzen van Zanten, Michael C Veronesi, Jan-Michael Werner, Martin van den Bent, Susan M Chang, Karl-Josef Langen, Ian Law, Jonathan McConathy, Minesh Mehta, Matthias Preusser, Susan C Short, Riccardo Soffietti, Michael Vogelbaum, Michael Weller, Patrick Y Wen, Joerg-Christian Tonn, Nathalie L Albert
LANCET ONCOLOGY, 2025, vol. 26, p.e436-e447
Correction to Nathalie L Albert, Norbert Galldiks, Benjamin M Ellingson, Martin J van den Bent, Susan M Chang, Francesco Cicone, Eng-Siew Koh, Ian Law, Emilie Le Rhun, Maximilian J Mair, Jan-Michael Werner, Anna S Berghoff, Julia Furtner, Giuseppe Minniti, Andrew M Scott, Susan C Short, Jana Ivanidze, Derek R Johnson, Bogdana Suchorska, Nelleke Tolboom, Joerg-Christian Tonn, Antoine Verger, Evanthia Galanis, Priscilla K Brastianos, Patrick Y Wen, Michael Weller, Nancy U Lin, Matthias Preusser
Nature medicine, 2025, vol. 31, p.2816
Intra-arterial Administration of Radiopharmaceuticals in Neuro-Oncology; New Improvement for [131I]-Phenylalanine in High-Grade Gliomas? N Tolboom, T J Snijders, E P A Vonken, I C van der Schaaf, T Seute, A J A T Braat
Cardiovascular and Interventional Radiology, 2025, vol. 48, p.725–728
RANO criteria for response assessment of brain metastases based on amino acid PET imaging Nathalie L Albert, Norbert Galldiks, Benjamin M Ellingson, Martin J van den Bent, Susan M Chang, Francesco Cicone, Eng-Siew Koh, Ian Law, Emilie Le Rhun, Maximilian J Mair, Jan-Michael Werner, Anna S Berghoff, Julia Furtner, Giuseppe Minniti, Andrew M Scott, Susan C Short, Jana Ivanidze, Derek R Johnson, Bogdana Suchorska, Nelleke Tolboom, Joerg-Christian Tonn, Antoine Verger, Eva Galanis, Priscilla K Brastianos, Patrick Y Wen, Michael Weller, Nancy U Lin, Matthias Preusser
Nature medicine, 2025, vol. 31, p.1424-1430
Dynamic PET imaging in patients with unilateral carotid occlusion shows lateralized cerebral hypoperfusion, but no amyloid binding Naomi Lp Starmans, Anna E Leeuwis, Edwin Bennink, Sebastiaan L Meyer Viol, Sandeep Sv Golla, Jan Willem Dankbaar, Esther E Bron, Geert Jan Biessels, L Jaap Kappelle, Wiesje M van der Flier, Nelleke Tolboom,
Journal of Alzheimer's disease : JAD, 2025, vol. 105, p.519-530