WEE1 inhibitors trigger GCN2-mediated activation of the integrated stress response
Rinskje B Tjeerdsma, Timothy F Ng, Maurits Roorda, Daniëlle Bianchi, Sora Yang, Clara Bonnet, Michael VanInsberghe, Marieke Everts, Femke J Bakker, H Rudolf de Boer, Nathalie Moatti, Nicole Hustedt, Jay Z Yin, Lisa Hoeg, Matthew Leibovitch, Frank Sicheri, Alexander van Oudenaarden, Steven de Jong, Jeroen van den Berg, Marvin E Tanenbaum, Thijn R Brummelkamp, Daniel Durocher, Marcel A T M van Vugt
Nature Communications, 2025, vol. 16
NASP modulates histone turnover to drive PARP inhibitor resistance
Sarah C Moser, Anna Khalizieva, Josef Roehsner, Elisabeth Pottendorfer, Milo L Kaptein, Giulia Ricci, Vivek Bhardwaj, Onno B Bleijerveld, Liesbeth Hoekman, Ingrid van der Heijden, Simone di Sanzo, Alexander Fish, Aleksandra Chikunova, Judith H I Haarhuis, Roel Oldenkamp, Luisa Robbez-Masson, Justin Sprengers, Daniel J Vis, Lodewyk F A Wessels, Marieke van de Ven, Stephen J Pettitt, Andrew N J Tutt, Christopher J Lord, Benjamin D Rowland, Moritz Völker-Albert, Francesca Mattiroli, Thijn R Brummelkamp, Abdelghani Mazouzi, Jos Jonkers
Nature, 2025, vol. 645, p.1071–1080
DNA damage induces p53-independent apoptosis through ribosome stalling
Nicolaas J Boon, Rafaela A Oliveira, Pierré-René Körner, Adva Kochavi, Sander Mertens, Yuval Malka, Rhianne Voogd, Suzanne E M van der Horst, Maarten A Huismans, Lidwien P Smabers, Jonne M Draper, Lodewyk F A Wessels, Peter Haahr, Jeanine M L Roodhart, Ton N M Schumacher, Hugo J Snippert, Reuven Agami, Thijn R Brummelkamp
Science, 2024, vol. 384, p.785-792
Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy
Meike E W Logtenberg, J H Marco Jansen, Matthijs Raaben, Mireille Toebes, Katka Franke, Arianne M Brandsma, Hanke L Matlung, Astrid Fauster, Raquel Gomez-Eerland, Noor A M Bakker, Simone van der Schot, Koen A Marijt, Martijn Verdoes, John B A G Haanen, Joost H van den Berg, Jacques Neefjes, Timo K van den Berg, Thijn R Brummelkamp, Jeanette H W Leusen, Ferenc A Scheeren, Ton N Schumacher
Nature Medicine, 2019, vol. 25, p.612-619