Profile photo Theo van den Broek

Theo van den Broek

Assistant Professor

Strategic program(s):

Biography

Theo van den Broek is trained as a medical specialist (medical microbiology) and immunologist (Center for Translational Immunology), and is a translational researcher at heart. He obtained his PhD on the dynamics of T cell reconsitution following lymphopenia at the Utrecht University in 2015. During his clinical training he obtained a Marie Curie Global Fellowship for a postdoc in the lab of Prof. M.C. Carroll (Boston Children's Hospital & Harvard Medical School) in Boston (USA) to investigate the dynamics of loss of B cell tolerance in autoimmunity. Following his clinical training he combined his research with clinical microbiology. In 2023 he was awarded a VENI personal fellowship to investigate the interaction between T and B cells in the pediatric immune system.

Since 2023 he started his own research group at the Center for Translational Immunology (CTI). Van den Broek's team investigates the intricate interaction between T and B cells, exploring its implications for disease, effective immunity, and immune reconstitution 

In the last years he has been actively involved in the support of career development and training of early career researchers (ECRs). He is chair of the young Dutch Society of Immunology (youngNVVI) and boardmember of the UMC Utrecht young academy. He co-founded an international open-access scientific journal (Journal of Life Sciences, JoLS) and an associated postdoc community with the goal of training ECRs in peer-review. This initiative received (inter)national attention and resulted in his appointment as the alumnus of the month at Utrecht University.

Research groups

T:B cell interactions in human lymph nodes

Research aim

Our mission is to investigate the complex interactions between T and B cells within human lymph nodes, aiming to drive meaningful clinical advancements.

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Recent publications

Invasion of spontaneous germinal centers by naive B cells is rapid and persistent Theo van den Broek, Kristine Oleinika, Siti Rahmayanti, Carlos Castrillon, Cees E van der Poel, Michael C Carroll
Science Immunology, 2024, vol. 9
Complex subsets but redundant clonality after B cells egress from spontaneous germinal centers Carlos Castrillon, Lea Simoni, Theo van den Broek, Cees van der Poel, Elliot H Akama-Garren, Minghe Ma, Michael C Carroll
eLife, 2023, vol. 12
Follicular T cells are clonally and transcriptionally distinct in B cell-driven mouse autoimmune disease Elliot H Akama-Garren, Theo van den Broek, Lea Simoni, Carlos Castrillon, Cees E van der Poel, Michael C Carroll
Nature Communications, 2021, vol. 12, p.6687
Prepare PhD holders for different career tracks Theo van den Broek, Berent Prakken, Frank Miedema
Nature, 2021, vol. 600, p.386
Coronavirus: postdoc winners need paid extensions Theo van den Broek, James Gould
Nature, 2020, vol. 583

Fellowships & Awards

2023: WKZ fonds: Boosting pediatric immunity: building a strong relationship between young T and B cells

2023: Veni - ZonMW (NWO)

2021: Ambasador of the month, at Immunopaedia

2021: Alumnus of the month - University of Utrecht

2021: I&I boost grant: To unravel the role of innate signals in the (pre-)differentiation and function of naïve T-cells.

2018: Marie Curie Individual Global Fellowship

2016: Scholarship (KNAW, Ter Meulen)

2012: Work visit scholarship (NVVI)

2012: Work visit scholarship (KNAW, Ter Meulen)

2012: Travel grant (PReS symposium)

2010: Travel grant (TRiPR symposium)

2008: Research Fellowship (Arizona Arthritis Center)

2007: Scholarship (Fulbright)

2007: Scholarship (Prince Bernhard Culture Foundation, via Carolus Magnus foundation)