Researchers Stefan Nierkens

Stefan Nierkens

Associate Professor

Strategic program(s):

Biography

Dr. Stefan Nierkens (PhD) is Associate Professor and Medical Immunologist, accredited according to guidelines of the College of Medical Immunologists of the Dutch Society of Immunology, in the UMC Utrecht and Princess Máxima Center for Pediatric Oncology. Within the ISO15189-accredited laboratory his focus areas are Hemato-oncology, Immune monitoring, Cell and functional diagnostics, and Serology.

Dr. Nierkens is Associate Professor Pediatric Tumor Immunology and HCT and focusses on the development of innovative immunotherapy treatment strategies (based on dendritic cells and gene-engineered T cells) to improve the outcome of pediatric cancers (e.g. acute leukemia and neuroblastoma). Furthermore, his lab (12 fte) focuses on the combination of advanced immune monitoring and PK-PD modeling to provide predictable immune reconstitution after hematopoietic cell transplantation.

Strategic program(s):

Contact

snierken@umcutrecht.nl

Pure profile

Research groups

Pediatric tumor immunology

Research aim

We strive to improve efficacy and safety of immune therapy against pediatric cancers, specifically focussing on the function of immune cells in children undergoing hematopoietic cell transplantation or receiving CAR-T cells.

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Primary immunodeficiency

Research aim

To address unmet medical needs by detecting novel primary immunodeficiency, and improving clinical practice by optimizing diagnosis, prognosis and treatment of disease.

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Recent publications

All publications

Targeting pediatric cancers via T-cell recognition of the monomorphic MHC class I-related protein MR1 Annelisa M Cornel, Loutje van der Sman, Jip T van Dinter, Marta Arrabito, Ester Dunnebach, Marliek van Hoesel, Thomas A Kluiver, Ana P Lopes, Noël M M Dautzenberg, Linde Dekker, Jorik M van Rijn, Denise A M H van den Beemt, Juliane L Buhl, Aimee du Chatinier, Farnaz Barneh, Yuyan Lu, Luca Lo Nigro, Anja Krippner-Heidenreich, Zsolt Sebestyén, Jurgen Kuball, Esther Hulleman, Jarno Drost, Sebastiaan van Heesch, Olaf T Heidenreich, Weng Chuan Peng, Stefan Nierkens
Journal for ImmunoTherapy of Cancer, 2024, vol. 12

Long-term immunity after BNT162b2 mRNA COVID-19 vaccination in pediatric patients with cancer K. L.Juliëtte Schmidt, Noortje R. Severeijns, Noël M.M. Dautzenberg, Peter M. Hoogerbrugge, Caroline A. Lindemans, Stefan Nierkens, Gaby Smits, Rob S. van Binnendijk, Marta Fiocco, Louis J. Bont, Wim J.E. Tissing
EJC Paediatric Oncology, 2024, vol. 4, p.1-4

Pharmacokinetics and Pharmacodynamics of Systemic Corticosteroids in Autoimmune and Inflammatory Diseases Julia E. Möhlmann, Solaiman Ezzafzafi, Caroline A. Lindemans, Marc H.A. Jansen, Stefan Nierkens, Alwin D.R. Huitema, Matthijs van Luin
Clinical Pharmacokinetics, 2024, vol. 63, p.1251-1270

Clinical and Biological Concepts for Mastering Immune Reconstitution After Hematopoietic Cell Transplantation Jürgen Kuball, Raffaella Greco, Stefan Nierkens, Jaap Jan Boelens
2024, p.85-96

Thymic NK-Cells and Their Potential in Cancer Immunotherapy Caitlyn Forbes, Stefan Nierkens, Annelisa M. Cornel
ImmunoTargets and Therapy, 2024, vol. 13, p.183-194

Heterozygous missense CSF1R variants hamper in vitro CD34+-derived dendritic cell generation but not in vivo dendritic cell development Shanice Beerepoot, Nicole I Wolf, Marjo S van der Knaap, Stefan Nierkens, Maud Plantinga
Molecular Immunology, 2024, vol. 174, p.41-46

Fellowships & Awards

2023: Joos Kerckhaert Award

External positions

Medische Immunologie - Overeenkomstige taken als Medisch Immunoloog bij LTI UMCU - Prinses Maxima Centrum voor Kinderoncologie

commissie - expertise medische immunologie - NVVI