Researchers Stefan Nierkens

Stefan Nierkens

Associate Professor

Strategic program(s):

Biography

Dr. Stefan Nierkens (PhD) is Associate Professor and Medical Immunologist, accredited according to guidelines of the College of Medical Immunologists of the Dutch Society of Immunology, in the UMC Utrecht and Princess Máxima Center for Pediatric Oncology. Within the ISO15189-accredited laboratory his focus areas are Hemato-oncology, Immune monitoring, Cell and functional diagnostics, and Serology.

Dr. Nierkens is Associate Professor Pediatric Tumor Immunology and HCT and focusses on the development of innovative immunotherapy treatment strategies (based on dendritic cells and gene-engineered T cells) to improve the outcome of pediatric cancers (e.g. acute leukemia and neuroblastoma). Furthermore, his lab (12 fte) focuses on the combination of advanced immune monitoring and PK-PD modeling to provide predictable immune reconstitution after hematopoietic cell transplantation.

Strategic program(s):

Contact

snierken@umcutrecht.nl

Pure profile

Research groups

Pediatric tumor immunology

Research aim

We strive to improve efficacy and safety of immune therapy against pediatric cancers, specifically focussing on the function of immune cells in children undergoing hematopoietic cell transplantation or receiving CAR-T cells.

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Primary immunodeficiency

Research aim

To address unmet medical needs by detecting novel primary immunodeficiency, and improving clinical practice by optimizing diagnosis, prognosis and treatment of disease.

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Recent publications

All publications

Loss of p53 impairs death receptor expression and confers resistance to CD19 CAR T-cell therapy in BCP-ALL Willem P J Cox, Noël M M Dautzenberg, Linde Dekker, Tesa Klenovsek, Annelisa M Cornel, Marliek van Hoesel, Dorette S van Ingen Schenau, Reno S Bladergroen, Roland P Kuiper, Laurens T van der Meer, Friso G Calkoen, Stefan Nierkens, Frank N van Leeuwen
Blood Neoplasia, 2025, vol. 2

Improved survival with model-based dosing of antithymocyte globulin in pediatric hematopoietic cell transplantation Rick Admiraal, Stefan Nierkens, Marc B. Bierings, Mirjam E. Belderbos, Alwin D. Huitema, Robbert G.M. Bredius, Yilin Jiang, Kevin J. Curran, Andromachi Scaradavou, Maria I. Cancio, Elizabeth Klein, Wouter J. Kollen, Dorine Bresters, Friso G.J. Calkoen, A. Birgitta Versluijs, C. Michel Zwaan, Jaap Jan Boelens, Caroline A. Lindemans
Blood Advances, 2025, vol. 9, p.2344-2353

Engineering anti-BCMA CAR T cells for enhancing myeloma killing efficacy via apoptosis regulation Thomas Kimman, Marta Cuenca, Ralph G Tieland, Dedeke Rockx-Brouwer, Jasmijn Janssen, Benjamin Motais, Anne Slomp, Corine Pleijte, Sabine Heijhuurs, Angelo D Meringa, Wendy Boschloo, Douwe Mt Bosma, Sanne Kroos, Vania Lo Presti, Joost P G Sluijter, Stefan Nierkens, Niels Bovenschen, Jürgen Kuball, Alain van Mil, Monique C Minnema, Zsolt Sebestyén, Victor Peperzak
Nature Communications, 2025, vol. 16

Increased Clonal Hematopoiesis in Long-term Survivors of Pediatric Hematopoietic Cell Transplantation Konradin F. Müskens, Nienke Wieringa, Maaike G.J.M. van Bergen, Joëll E. Bense, Brigit M. Te Pas, Anne P.J. de Pagter, Arjan C. Lankester, Marc B. Bierings, Donna S. Neuberg, Saskia Haitjema, Leontien C.M. Kremer, Gerwin A. Huls, Stefan Nierkens, Joop H. Jansen, Caroline A. Lindemans, Aniek O. de Graaf, Mirjam E. Belderbos
Blood cancer discovery, 2025, vol. 6, p.110-118

Ex vivo T-lymphopoiesis assays assisting corrective treatment choice for genetically undefined T-lymphocytopaenia Zainab M Golwala, Helena Spiridou Goncalves, Ranjita Devi Moirangthem, Grace Evans, Sabrina Lizot, Coco de Koning, Alexandrine Garrigue, Marta Martin Corredera, Juan Moises Ocampo-Godinez, Evey Howley, Susanne Kricke, Arnold Awuah, Irene Obiri-Yeboa, Rajeev Rai, Neil Sebire, Fanette Bernard, Victoria Bordon Cueto De Braem, Kaan Boztug, Theresa Cole, Andrew R Gennery, Scott Hackett, Sophie Hambleton, Mette Holm, Maaike A Kusters, Adam Klocperk, Antonio Marzollo, Nufar Marcus, Zohreh Nademi, Jana Pachlopnik Schmid, Herbert Pichler, Anna Sellmer, Pere Soler-Palacin, Maarja Soomann, Paul Torpiano, Joris van Montfrans, Stefan Nierkens, Stuart Adams, Matthew Buckland, Kimberly Gilmour, Austen Worth, Adrian J Thrasher, E Graham Davies, Isabelle André, Alexandra Y Kreins
Clinical Immunology, 2025, vol. 274

Multicenter validation of secondary hemophagocytic lymphohistiocytosis diagnostic criteria Gunnar Lachmann, Patrick Heeren, Friederike S. Schuster, Peter Nyvlt, Claudia Spies, Insa Feinkohl, Thomas Schenk, Wafa Ammouri, France Debaugnies, Lionel Galicier, Yuan Jia, Nikhil Meena, Carole Nagant, Olaf Neth, Stefan Nierkens, Juan San Martin, Hao Wei Sun, Yini Wang, Zhao Wang, Jae Ho Yoon, Frank M. Brunkhorst, Paul La Rosée, Gritta Janka, Cornelia Lachmann
Journal of Internal Medicine, 2025, vol. 297, p.312-327

Fellowships & Awards

KWF fellowship

Kika

ZonMW-TAS

VillaJoep

Ammodo

External positions

Medische Immunologie - Overeenkomstige taken als Medisch Immunoloog bij LTI UMCU - Prinses Maxima Centrum voor Kinderoncologie

commissie - expertise medische immunologie - NVVI