Hugo Snippert

Associate Professor

Strategic program(s):

Contact

hsnipper@umcutrecht.nl

Pure profile

Research groups

Early (T1-T2) colorectal cancers

Research aim

To minimize the impact of treatment for early (T1-T2) colorectal cancers, while preserving the high survival rates, achieve the highest quality of life for patients, and lower the healthcare costs.

Go to group

Recent publications

All publications

Impact of treatment history on drug resistance of metastatic colorectal cancer organoids Maarten A. Huismans, Lidwien P. Smabers, Sascha R. Brunner, Arne van Hoeck, Demi van de Kaa, Ingrid A. Franken, Emerens Wensink, Jan Koster, Richard Volckmann, Onno Kranenburg, Miriam Koopman, Hugo J.G. Snippert, Jeanine M.L. Roodhart
iScience, 2025, vol. 28

Intestinal tuft cell subtypes represent successive stages of maturation driven by crypt-villus signaling gradients Julian R Buissant des Amorie, Max A Betjes, Jochem H Bernink, Joris H Hageman, Veerle E Geurts, Harry Begthel, Dimitrios Laskaris, Maria C Heinz, Ingrid Jordens, Tiba Vinck, Ronja M Houtekamer, Ingrid Verlaan-Klink, Sascha R Brunner, Jacco van Rheenen, Martijn Gloerich, Hans Clevers, Sander J Tans, Jeroen S van Zon, Hugo J G Snippert
Nature Communications, 2025, vol. 16

BRAF^V600E augments WNT signaling in colorectal cancer via aberrant DNA methylation Layla El Bouazzaoui, Jeroen M. Bugter, Emre Küçükköse, André Verheem, Jasmin B. Post, Nicola Fenderico, Inne H.M. Borel Rinkes, Hugo J.G. Snippert, Madelon M. Maurice, Onno Kranenburg
iScience, 2025, vol. 28

BRAF^V600E maintains the CpG island methylator phenotype, and DNA methylation of PRC2 targets genes in colon cancer Layla El Bouazzaoui, Jeroen M. Bugter, Emre Küçükköse, André Verheem, Jasmin B. Post, Nicola Fenderico, Inne H.M. Borel Rinkes, Hugo J.G. Snippert, Madelon M. Maurice, Onno Kranenburg
iScience, 2025, vol. 28

Resistance to MAPK Pathway Inhibition in BRAF-V600E Mutant Colorectal Cancer Can Be Overcome with Insulin Receptor/Insulin-like Growth Factor-1 Receptor Inhibitors Layla El Bouazzaoui, Daniëlle A.E. Raats, André Verheem, Inne H.M.Borel Rinkes, Hugo J.G. Snippert, Madelon M. Maurice, Onno Kranenburg
Organoids, 2025, vol. 4

Response to systemic therapies in patient-derived cell lines from primary and recurrent adult granulosa cell tumors Geertruid J Brink, Nizar Hami, Sander Mertens, Hans W Nijman, Luc Rcw van Lonkhuijzen, Eva Maria Roes, Christine A R Lok, Cornelis D de Kroon, Jurgen Mj Piek, Ward Hofhuis, Hugo J G Snippert, Jolijn Willemijntje Groeneweg, Petronella O Witteveen, Ronald P Zweemer
MOLECULAR CANCER THERAPEUTICS, 2024, vol. 24, p.628-638