Hugo Snippert

Associate Professor

Strategic program(s):

Contact

hsnipper@umcutrecht.nl

Pure profile

Research groups

Early (T1-T2) colorectal cancers

Research aim

To minimize the impact of treatment for early (T1-T2) colorectal cancers, while preserving the high survival rates, achieve the highest quality of life for patients, and lower the healthcare costs.

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Recent publications

All publications

BRAF^V600E augments WNT signaling in colorectal cancer via aberrant DNA methylation Layla El Bouazzaoui, Jeroen M. Bugter, Emre Küçükköse, André Verheem, Jasmin B. Post, Nicola Fenderico, Inne H.M. Borel Rinkes, Hugo J.G. Snippert, Madelon M. Maurice, Onno Kranenburg
iScience, 2025, vol. 28

BRAF^V600E maintains the CpG island methylator phenotype, and DNA methylation of PRC2 targets genes in colon cancer Layla El Bouazzaoui, Jeroen M. Bugter, Emre Küçükköse, André Verheem, Jasmin B. Post, Nicola Fenderico, Inne H.M. Borel Rinkes, Hugo J.G. Snippert, Madelon M. Maurice, Onno Kranenburg
iScience, 2025, vol. 28

Resistance to MAPK Pathway Inhibition in BRAF-V600E Mutant Colorectal Cancer Can Be Overcome with Insulin Receptor/Insulin-like Growth Factor-1 Receptor Inhibitors Layla El Bouazzaoui, Daniëlle A.E. Raats, André Verheem, Inne H.M.Borel Rinkes, Hugo J.G. Snippert, Madelon M. Maurice, Onno Kranenburg
Organoids, 2025, vol. 4

Response to systemic therapies in patient-derived cell lines from primary and recurrent adult granulosa cell tumors Geertruid J Brink, Nizar Hami, Sander Mertens, Hans W Nijman, Luc Rcw van Lonkhuijzen, Eva Maria Roes, Christine A R Lok, Cornelis D de Kroon, Jurgen Mj Piek, Ward Hofhuis, Hugo J G Snippert, Jolijn Willemijntje Groeneweg, Petronella O Witteveen, Ronald P Zweemer
MOLECULAR CANCER THERAPEUTICS, 2024, vol. 24, p.628-638

Efficacy and safety in early-phase clinical trials for refractory colorectal cancer Lidwien P Smabers, Maarten A Huismans, Niels van Nieuwenhuijzen, Monique C Minnema, Onno Kranenburg, Miriam Koopman, Hugo J G Snippert, Anne M May, Jeanine M L Roodhart
European Journal of Cancer, 2024, vol. 212

Homopolymer switches mediate adaptive mutability in mismatch repair-deficient colorectal cancer Hamzeh Kayhanian, William Cross, Suzanne E M van der Horst, Panagiotis Barmpoutis, Eszter Lakatos, Giulio Caravagna, Luis Zapata, Arne Van Hoeck, Sjors Middelkamp, Kevin Litchfield, Christopher Steele, William Waddingham, Dominic Patel, Salvatore Milite, Chen Jin, Ann-Marie Baker, Daniel C Alexander, Khurum Khan, Daniel Hochhauser, Marco Novelli, Benjamin Werner, Ruben van Boxtel, Joris H Hageman, Julian R Buissant des Amorie, Josep Linares, Marjolijn J L Ligtenberg, Iris D Nagtegaal, Miangela M Laclé, Leon M G Moons, Lodewijk A A Brosens, Nischalan Pillay, Andrea Sottoriva, Trevor A Graham, Manuel Rodriguez-Justo, Kai-Keen Shiu, Hugo J G Snippert, Marnix Jansen
Nature Genetics, 2024, vol. 56, p.1420-1433