Hugo Snippert

Associate Professor

Strategic program(s):

Contact

hsnipper@umcutrecht.nl

Pure profile

Research groups

Early (T1-T2) colorectal cancers

Research aim

To minimize the impact of treatment for early (T1-T2) colorectal cancers, while preserving the high survival rates, achieve the highest quality of life for patients, and lower the healthcare costs.

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Recent publications

All publications

Impact of treatment history on drug resistance of metastatic colorectal cancer organoids Maarten A. Huismans, Lidwien P. Smabers, Sascha R. Brunner, Arne van Hoeck, Demi van de Kaa, Ingrid A. Franken, Emerens Wensink, Jan Koster, Richard Volckmann, Onno Kranenburg, Miriam Koopman, Hugo J.G. Snippert, Jeanine M.L. Roodhart
iScience, 2025, vol. 28

APOBEC3A drives deaminase mutagenesis in human gastric epithelium Yohan An, Ji-Hyun Lee, Joonoh Lim, Jeonghwan Youk, Seongyeol Park, Ji-Hyung Park, Kijong Yi, Taewoo Kim, Chang Hyun Nam, Won Hee Lee, Soo A Oh, Yoo Jin Bae, Thomas M Klompstra, Haeun Lee, Jinju Han, Junehwak Lee, Jung Woo Park, Jie-Hyun Kim, Hyunki Kim, Hugo Snippert, Bon-Kyoung Koo, Young Seok Ju
Genome Research, 2025, vol. 35, p.2158-2172

Intestinal tuft cell subtypes represent successive stages of maturation driven by crypt-villus signaling gradients Julian R Buissant des Amorie, Max A Betjes, Jochem H Bernink, Joris H Hageman, Veerle E Geurts, Harry Begthel, Dimitrios Laskaris, Maria C Heinz, Ingrid Jordens, Tiba Vinck, Ronja M Houtekamer, Ingrid Verlaan-Klink, Sascha R Brunner, Jacco van Rheenen, Martijn Gloerich, Hans Clevers, Sander J Tans, Jeroen S van Zon, Hugo J G Snippert
Nature Communications, 2025, vol. 16

BRAF^V600E augments WNT signaling in colorectal cancer via aberrant DNA methylation Layla El Bouazzaoui, Jeroen M. Bugter, Emre Küçükköse, André Verheem, Jasmin B. Post, Nicola Fenderico, Inne H.M. Borel Rinkes, Hugo J.G. Snippert, Madelon M. Maurice, Onno Kranenburg
iScience, 2025, vol. 28

BRAF^V600E maintains the CpG island methylator phenotype, and DNA methylation of PRC2 targets genes in colon cancer Layla El Bouazzaoui, Jeroen M. Bugter, Emre Küçükköse, André Verheem, Jasmin B. Post, Nicola Fenderico, Inne H.M. Borel Rinkes, Hugo J.G. Snippert, Madelon M. Maurice, Onno Kranenburg
iScience, 2025, vol. 28

Resistance to MAPK Pathway Inhibition in BRAF-V600E Mutant Colorectal Cancer Can Be Overcome with Insulin Receptor/Insulin-like Growth Factor-1 Receptor Inhibitors Layla El Bouazzaoui, Daniëlle A.E. Raats, André Verheem, Inne H.M.Borel Rinkes, Hugo J.G. Snippert, Madelon M. Maurice, Onno Kranenburg
Organoids, 2025, vol. 4