Saskia de Jager

Associate Professor

Strategic program(s):

Contact

sjager@umcutrecht.nl

Pure profile

Research groups

Molecular science & therapy in heart failure

Research aim

Current available therapies for chronic heart diseases only alleviate symptoms and prevent the disease from becoming worse. We aim to improve our understanding of heart failure and develop new strategies for therapy.

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Recent publications

All publications

CCL18 aggravates atherosclerosis by inducing CCR6-dependent T-cell influx and polarization Anjana Singh, Adriaan O Kraaijeveld, Adelina Curaj, Kanin Wichapong, Linda Hammerich, Saskia C A de Jager, Ilze Bot, Sergei P Atamas, Theo J C van Berkel, J Wouter Jukema, Iain Comerford, Shaun R McColl, Barend Mees, Johan W M Heemskerk, Gerry A F Nicolaes, Tilman Hackeng, Elisa Anamaria Liehn, Frank Tacke, Erik A L Biessen
Frontiers in Immunology, 2024, vol. 15

Cardiac delivery of modified mRNA using lipid nanoparticles M C I Labonia, M Estapé Senti, P H van der Kraak, M A D Brans, I Dokter, T J Streef, A M Smits, A K Deshantri, S C A de Jager, R M Schiffelers, J P G Sluijter, P Vader
Journal of controlled release : official journal of the Controlled Release Society, 2024, vol. 369, p.734-745

Cold exposure increases circulating fibroblast growth factor 21 in the eveninin males and females Carlijn A. Hoekx, Borja Martinez-Tellez, Maaike E. Straat, Magdalena M.A. Verkleij, Mirjam Kemmeren, Sander Kooijman, Martin Uhrbom, Saskia C.A. de Jager, Patrick C.N. Rensen, Mariëtte R. Boon
Endocrine connections, 2024, vol. 13

Growth differentiation factor 15 is not modified after weight loss induced by liraglutide in South Asians and Europids with type 2 diabetes mellitus Carlijn A. Hoekx, Maaike E. Straat, Maurice B. Bizino, Huub J. van Eyk, Hildebrandus J. Lamb, Johannes W.A. Smit, Ingrid M. Jazet, Saskia C.A. de Jager, Mariëtte R. Boon, Borja Martinez-Tellez
Experimental physiology, 2024, vol. 109, p.1292-1304

Extracellular vesicle-mediated delivery of CRISPR/Cas9 ribonucleoprotein complex targeting proprotein convertase subtilisin-kexin type 9 (Pcsk9) in primary mouse hepatocytes Nazma F Ilahibaks, Thomas A Kluiver, Olivier G de Jong, Saskia C A de Jager, Raymond M Schiffelers, Pieter Vader, Weng Chuan Peng, Zhiyong Lei, Joost P G Sluijter
Journal of Extracellular Vesicles, 2024, vol. 13

Hypoxia and TNF-alpha modulate extracellular vesicle release from human induced pluripotent stem cell-derived cardiomyocytes Margarida Viola, Maarten P. Bebelman, Renee G.C. Maas, Willemijn S. de Voogt, Frederik J. Verweij, Cor S. Seinen, Saskia C.A. de Jager, Pieter Vader, Dirk Michiel Pegtel, Joost Petrus Gerardus Sluijter
Journal of Extracellular Vesicles, 2024, vol. 13