Sacha Spelier

Researcher/Postdoc

Strategic program(s):

Contact

aspelie2@umcutrecht.nl

Pure profile

Recent publications

All publications

The Promising Role of Intestinal Organoids in the Diagnostic Work-Up of Cystic Fibrosis Screen Positive Inconclusive Diagnosis/CFTR-Related Metabolic Syndrome (CFSPID/CRMS) Noelia Rodriguez Mier, Marlies Destoop, Sacha Spelier, Anabela Santo Ramalho, Jeffrey M Beekman, François Vermeulen, Marijke Proesmans, Karin M de Winter-de Groot
International Journal of Neonatal Screening, 2025, vol. 11

ACE-tRNAs are a platform technology for suppressing nonsense mutations that cause cystic fibrosis Wooree Ko, Joseph J Porter, Sacha Spelier, Emily G Sorensen, Priyanka Bhatt, Jeffrey T Gabell, Isabelle van der Windt, Tyler Couch, Kevin Coote, Martin Mense, Jeffrey M Beekman, John D Lueck
Nucleic acids research, 2025, vol. 53

CFTR and colorectal cancer susceptibility S Spelier, S Derksen, R Hofland, J M Beekman, B Yetkin-Arik
Trends in Cancer, 2024, vol. 10, p.876-879

Making sense of nonsense in the context of Cystic Fibrosis Sacha Spelier
2024

Organoid-guided synergistic treatment of minimal function CFTR mutations with CFTR modulators, roflumilast and simvastatin Sacha Spelier, Karin de Winter-de Groot, Natascha Keijzer-Nieuwenhuijze, Yves Liem, Kors van der Ent, Jeffrey Beekman, Lieke S. Kamphuis
The European respiratory journal, 2023, vol. 63

FDA-approved drug screening in patient-derived organoids demonstrates potential of drug repurposing for rare cystic fibrosis genotypes E. de Poel, S. Spelier, M. C. Hagemeijer, P. van Mourik, S. W.F. Suen, A. M. Vonk, J. E. Brunsveld, G. N. Ithakisiou, E. Kruisselbrink, H. Oppelaar, G. Berkers, K. M. de Winter de Groot, S. Heida-Michel, S. R. Jans, H. van Panhuis, M. Bakker, R. van der Meer, J. Roukema, E. Dompeling, E. J.M. Weersink, G. H. Koppelman, A. R. Blaazer, J. E. Muijlwijk-Koezen, C. K. van der Ent, J. M. Beekman
Journal of Cystic Fibrosis, 2023, vol. 22, p.548-559