Sabine Linn

Full Professor

Strategic program(s):

Contact

slinn2@umcutrecht.nl

Pure profile

Research groups

Translational breast cancer research group

Research aim

We aim to optimize early diagnosis and treatment of breast cancer, especially rare breast cancers like pregnancy associated, male & lobular breast cancer. We refine tissue diagnostics with molecular techniques/AI, and apply nipple fluid/blood tests.

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Recent publications

All publications

Estrogen receptor 1 chromatin profiling in human breast tumors reveals high inter-patient heterogeneity with enrichment of risk SNPs and enhancer activity at most-conserved regions Stacey E P Joosten, Sebastian Gregoricchio, Suzan Stelloo, Elif Yapıcı, Chia-Chi Flora Huang, Kerim Yavuz, Maria Donaldson Collier, Tunç Morova, Umut Berkay Altintaş, Yongsoo Kim, Sander Canisius, Cathy B Moelans, Paul J van Diest, Gozde Korkmaz, Nathan A Lack, Michiel Vermeulen, Sabine C Linn, Wilbert Zwart
Genome Research, 2024, vol. 34, p.539-555

Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancer Roberto A. Leon-Ferre, Sarah Flora Jonas, Roberto Salgado, Sherene Loi, Vincent De Jong, Jodi M. Carter, Torsten O. Nielsen, Samuel Leung, Nazia Riaz, Stephen Chia, Gérôme Jules-Clément, Giuseppe Curigliano, Carmen Criscitiello, Vincent Cockenpot, Matteo Lambertini, Vera J. Suman, Barbro Linderholm, John W.M. Martens, Carolien H.M. Van Deurzen, A. Mieke Timmermans, Tatsunori Shimoi, Shu Yazaki, Masayuki Yoshida, Sung Bae Kim, Hee Jin Lee, Maria Vittoria Dieci, Guillaume Bataillon, Anne Vincent-Salomon, Fabrice André, Marleen Kok, Sabine C. Linn, Matthew P. Goetz, Stefan Michiels
JAMA, 2024, vol. 331, p.1135-1144

Cox proportional hazards regression in small studies of predictive biomarkers K. Jóźwiak, V. H. Nguyen, L. Sollfrank, S. C. Linn, M. Hauptmann
Scientific Reports, 2024, vol. 14

Characterization of HER2-low breast cancer in young women with germline BRCA1/2 pathogenetic variants Francesco Schettini, Eva Blondeaux, Chiara Molinelli, Raphaëlle Bas, Hee Jeong Kim, Antonio Di Meglio, Rinat Bernstein Molho, Sabine C. Linn, Katarzyna Pogoda, Estela Carrasco, Kevin Punie, Elisa Agostinetto, Nerea Lopetegui-Lia, Kelly Anne Phillips, Angela Toss, Christine Rousset-Jablonski, Marion Acheritogaray, Alberta Ferrari, Shani Paluch-Shimon, Robert Fruscio, Wanda Cui, Stephanie M. Wong, Claudio Vernieri, Maria Vittoria Dieci, Alexios Matikas, Mariya Rozenblit, Cynthia Villarreal-Garza, Laura De Marchis, Fabio Puglisi, Leonor Vasconcelos de Matos, Monica Mariño, Luis Teixeira, Rossella Graffeo, Alessia Rognone, Alessandra Chirco, Nicoleta Antone, Yara Abdou, Maximilian Marhold, Ivana Božović-Spasojević, Alfonso Cortés Salgado, Luca Carmisciano, Marco Bruzzone, Giuseppe Curigliano, Aleix Prat, Matteo Lambertini
Cancer, 2024, vol. 130, p.2746-2762

Long-term outcomes of young, node-negative, chemotherapy-naïve, triple-negative breast cancer patients according to BRCA1 status Yuwei Wang, Gwen M H E Dackus, Efraim H Rosenberg, Sten Cornelissen, Leonora W de Boo, Annegien Broeks, Wim Brugman, Terry W S Chan, Paul J van Diest, Michael Hauptmann, Natalie D Ter Hoeve, Olga I Isaeva, Vincent M T de Jong, Katarzyna Jóźwiak, Roelof J C Kluin, Marleen Kok, Esther Koop, Petra M Nederlof, Mark Opdam, Philip C Schouten, Sabine Siesling, Charlaine van Steenis, Adri C Voogd, Willem Vreuls, Roberto F Salgado, Sabine C Linn, Marjanka K Schmidt
BMC Medicine, 2024, vol. 22, p.1-14

Olaparib Addition to Maintenance Bevacizumab Therapy in Ovarian Carcinoma with BRCA -Like Genomic Aberrations Philip C. Schouten, Sandra Schmidt, Kerstin Becker, Holger Thiele, Peter Nürnberg, Lisa Richters, Corinna Ernst, Isabelle Treilleux, Jacques Medioni, Florian Heitz, Carmela Pisano, Yolanda Garcia, Edgar Petru, Sakari Hietanen, Nicoletta Colombo, Ignace Vergote, Shoji Nagao, Sabine C. Linn, Eric Pujade-Lauraine, Isabelle Ray-Coquard, Philipp Harter, Eric Hahnen, Rita K. Schmutzler
JAMA network open, 2024, vol. 7