Sabine Linn

Full Professor

Strategic program(s):

Contact

slinn2@umcutrecht.nl

Pure profile

Research groups

Translational breast cancer research group

Research aim

We aim to optimize early diagnosis and treatment of breast cancer, especially rare breast cancers like pregnancy associated, male & lobular breast cancer. We refine tissue diagnostics with molecular techniques/AI, and apply nipple fluid/blood tests.

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Recent publications

All publications

Tumor-Infiltrating Lymphocytes in Patients with Stage i Triple-Negative Breast Cancer Untreated with Chemotherapy Veerle C.M. Geurts, Sara Balduzzi, Tessa G. Steenbruggen, Sabine C. Linn, Sabine Siesling, Sunil S. Badve, Angela Demichele, Michail Ignatiadis, Roberto A. Leon-Ferre, Matthew P. Goetz, Antonio C. Wolff, Natalie Klar, Stefan Michiels, Sherene Loi, Sylvia Adams, Hugo M. Horlings, Gabe S. Sonke, Roberto Salgado, Marleen Kok
JAMA Oncology, 2024, vol. 10, p.1077-1086

Estrogen receptor 1 chromatin profiling in human breast tumors reveals high inter-patient heterogeneity with enrichment of risk SNPs and enhancer activity at most-conserved regions Stacey E P Joosten, Sebastian Gregoricchio, Suzan Stelloo, Elif Yapıcı, Chia-Chi Flora Huang, Kerim Yavuz, Maria Donaldson Collier, Tunç Morova, Umut Berkay Altintaş, Yongsoo Kim, Sander Canisius, Cathy B Moelans, Paul J van Diest, Gozde Korkmaz, Nathan A Lack, Michiel Vermeulen, Sabine C Linn, Wilbert Zwart
Genome Research, 2024, vol. 34, p.539-555

Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancer Roberto A. Leon-Ferre, Sarah Flora Jonas, Roberto Salgado, Sherene Loi, Vincent De Jong, Jodi M. Carter, Torsten O. Nielsen, Samuel Leung, Nazia Riaz, Stephen Chia, Gérôme Jules-Clément, Giuseppe Curigliano, Carmen Criscitiello, Vincent Cockenpot, Matteo Lambertini, Vera J. Suman, Barbro Linderholm, John W.M. Martens, Carolien H.M. Van Deurzen, A. Mieke Timmermans, Tatsunori Shimoi, Shu Yazaki, Masayuki Yoshida, Sung Bae Kim, Hee Jin Lee, Maria Vittoria Dieci, Guillaume Bataillon, Anne Vincent-Salomon, Fabrice André, Marleen Kok, Sabine C. Linn, Matthew P. Goetz, Stefan Michiels
JAMA, 2024, vol. 331, p.1135-1144

High-dose chemotherapy for patients with stage III breast cancer with homologous recombination deficiency Joost G.E. Verbeek, Leyla Azarang, Luis E. Pilli, Vincent M.T. De Jong, Agnes Jager, Sabine C. Linn, Valesca P. Retèl, Wim H. Van Harten
Acta oncologica (Stockholm, Sweden), 2024, vol. 63, p.701-709

Predictive gene expression profile for adjuvant taxane benefit in breast cancer in the MATADOR trial Mark Opdam, Annelot G.J. van Rossum, Marlous Hoogstraat, Gergana Bounova, Hugo M. Horlings, Erik van Werkhoven, Ingrid A.M. Mandjes, A. Elise van Leeuwen – Stok, Sander Canisius, Harm van Tinteren, Alex L.T. Imholz, Johanneke E.A. Portielje, Monique E.M.M. Bos, Sandra Bakker, Jelle Wesseling, Lennart Kester, Jacco van Rheenen, Emiel J. Rutgers, Renee X. de Menezes, Lodewyk F.A. Wessels, Marleen Kok, Hendrika M. Oosterkamp, Sabine C. Linn, Marcel Soesan, Rianne M. Oosterkamp, Frank Jeurissen, Nir Weijl, Karin J. Beelen, Aart van Bochove, Gerty de Klerk, Suzan Vrijaldenhoven, Annette van der Velden, Hiltje de Graaf, Marielle Smeets, Jetske Meerum Terwogt, Jolanda Schrama, Philomeen Kuijer, Hanneke Wilmink, Ronald Hoekstra, Judith Kroep, Hans F.M. Pruijt, Leander van Gerven, Allert H. Vos, Frans Erdkamp, Willemien G. van Leeuwen-Breuk, Alexander de Graeff,
iScience, 2024, vol. 27

Cox proportional hazards regression in small studies of predictive biomarkers K. Jóźwiak, V. H. Nguyen, L. Sollfrank, S. C. Linn, M. Hauptmann
Scientific Reports, 2024, vol. 14