Sabine Linn

Full Professor

Strategic program(s):

Contact

slinn2@umcutrecht.nl

Pure profile

Research groups

Translational breast cancer research group

Research aim

We aim to optimize early diagnosis and treatment of breast cancer, especially rare breast cancers like pregnancy associated, male & lobular breast cancer. We refine tissue diagnostics with molecular techniques/AI, and apply nipple fluid/blood tests.

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Recent publications

All publications

Tumor-Infiltrating Lymphocytes in Patients with Stage i Triple-Negative Breast Cancer Untreated with Chemotherapy Veerle C.M. Geurts, Sara Balduzzi, Tessa G. Steenbruggen, Sabine C. Linn, Sabine Siesling, Sunil S. Badve, Angela Demichele, Michail Ignatiadis, Roberto A. Leon-Ferre, Matthew P. Goetz, Antonio C. Wolff, Natalie Klar, Stefan Michiels, Sherene Loi, Sylvia Adams, Hugo M. Horlings, Gabe S. Sonke, Roberto Salgado, Marleen Kok
JAMA Oncology, 2024, vol. 10, p.1077-1086

Estrogen receptor 1 chromatin profiling in human breast tumors reveals high inter-patient heterogeneity with enrichment of risk SNPs and enhancer activity at most-conserved regions Stacey E P Joosten, Sebastian Gregoricchio, Suzan Stelloo, Elif Yapıcı, Chia-Chi Flora Huang, Kerim Yavuz, Maria Donaldson Collier, Tunç Morova, Umut Berkay Altintaş, Yongsoo Kim, Sander Canisius, Cathy B Moelans, Paul J van Diest, Gozde Korkmaz, Nathan A Lack, Michiel Vermeulen, Sabine C Linn, Wilbert Zwart
Genome Research, 2024, vol. 34, p.539-555

Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancer Roberto A. Leon-Ferre, Sarah Flora Jonas, Roberto Salgado, Sherene Loi, Vincent De Jong, Jodi M. Carter, Torsten O. Nielsen, Samuel Leung, Nazia Riaz, Stephen Chia, Gérôme Jules-Clément, Giuseppe Curigliano, Carmen Criscitiello, Vincent Cockenpot, Matteo Lambertini, Vera J. Suman, Barbro Linderholm, John W.M. Martens, Carolien H.M. Van Deurzen, A. Mieke Timmermans, Tatsunori Shimoi, Shu Yazaki, Masayuki Yoshida, Sung Bae Kim, Hee Jin Lee, Maria Vittoria Dieci, Guillaume Bataillon, Anne Vincent-Salomon, Fabrice André, Marleen Kok, Sabine C. Linn, Matthew P. Goetz, Stefan Michiels
JAMA, 2024, vol. 331, p.1135-1144

Cox proportional hazards regression in small studies of predictive biomarkers K. Jóźwiak, V. H. Nguyen, L. Sollfrank, S. C. Linn, M. Hauptmann
Scientific Reports, 2024, vol. 14

Academic Uphill Battle to Personalize Treatment for Patients With Stage II/III Triple-Negative Breast Cancer Marleen Kok, Robbert Jan Gielen, Sylvia Adams, Jochen K. Lennerz, Priyanka Sharma, Sibylle Loibl, Erin Reardon, Gabe Sonke, Sabine Linn, Suzette Delaloge, Denis Lacombe, Tim Robinson, Sunil Badve, Miguel Martin, Justin M. Balko, Michail Ignatiadis, Giuseppe Curigliano, Antonio C. Wolff, Elizabeth A. Mittendorf, Sherene Loi, Lajos Pusztai, Sara M. Tolaney, Roberto Salgado
Journal of Clinical Oncology, 2024, vol. 42, p.3523-3529

Characterization of HER2-low breast cancer in young women with germline BRCA1/2 pathogenetic variants Francesco Schettini, Eva Blondeaux, Chiara Molinelli, Raphaëlle Bas, Hee Jeong Kim, Antonio Di Meglio, Rinat Bernstein Molho, Sabine C. Linn, Katarzyna Pogoda, Estela Carrasco, Kevin Punie, Elisa Agostinetto, Nerea Lopetegui-Lia, Kelly Anne Phillips, Angela Toss, Christine Rousset-Jablonski, Marion Acheritogaray, Alberta Ferrari, Shani Paluch-Shimon, Robert Fruscio, Wanda Cui, Stephanie M. Wong, Claudio Vernieri, Maria Vittoria Dieci, Alexios Matikas, Mariya Rozenblit, Cynthia Villarreal-Garza, Laura De Marchis, Fabio Puglisi, Leonor Vasconcelos de Matos, Monica Mariño, Luis Teixeira, Rossella Graffeo, Alessia Rognone, Alessandra Chirco, Nicoleta Antone, Yara Abdou, Maximilian Marhold, Ivana Božović-Spasojević, Alfonso Cortés Salgado, Luca Carmisciano, Marco Bruzzone, Giuseppe Curigliano, Aleix Prat, Matteo Lambertini
Cancer, 2024, vol. 130, p.2746-2762