Profile photo Robin H. van der Weide

Robin H. van der Weide

Assistant Professor

Biography

Robin H. van der Weide is an Assistant Professor in computational and single-cell genomics at the Center for Molecular Medicine, UMC Utrecht. His research focuses on understanding how the many regulatory layers of the (epi)genome control cell identity in development and disease.

Robin combines cutting-edge experimental techniques with computational analysis to reveal hidden patterns in gene regulation. During his PhD at the Netherlands Cancer Institute, he showed how the Cohesin protein complex creates physical loops in DNA, fundamentally shaping how the genome is organized in three dimensions.

As a postdoctoral researcher at the Hubrecht Institute, he co-developed MAbID, a technology that measures multiple features of gene regulation simultaneously in thousands of individual cells. This innovation opened new ways to study how cells make decisions and led to a biotechnology spin-off.

His lab takes a holistic approach to studying what turns genes on or off in healthy and diseased cells: single-cell chromatin systems biology. Robin is passionate about training the next generation of scientists and building a collaborative, transparent research environment.

Research groups

Systems biology of gene regulation

Research aim

We aim to uncover the principles by which genome organization and epigenetic dynamics control gene regulation, and to understand how disruption of these systems reshapes cellular identity in disease.

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Recent publications

Combinatorial single-cell profiling of major chromatin types with MAbID Silke J.A. Lochs, Robin H. van der Weide, Kim L. de Luca, Tessy Korthout, Ramada E. van Beek, Hiroshi Kimura, Jop Kind
Nature Methods, 2024, vol. 21, p.72-82
Distinct roles for CKM–Mediator in controlling Polycomb-dependent chromosomal interactions and priming genes for induction Emilia Dimitrova, Angelika Feldmann, Robin H. van der Weide, Koen D. Flach, Anna Lastuvkova, Elzo de Wit, Robert J. Klose
Nature Structural and Molecular Biology, 2022, vol. 29, p.1000-1010
A Mediator-cohesin axis controls heterochromatin domain formation Judith H I Haarhuis, Robin H van der Weide, Vincent A Blomen, Koen D Flach, Hans Teunissen, Laureen Willems, Thijn R Brummelkamp, Benjamin D Rowland, Elzo de Wit
Nature Communications, 2022, vol. 13, p.754
Impact of chromatin context on Cas9-induced DNA double-strand break repair pathway balance Ruben Schep, Eva K. Brinkman, Christ Leemans, Xabier Vergara, Robin H. van der Weide, Ben Morris, Tom van Schaik, Stefano G. Manzo, Daniel Peric-Hupkes, Jeroen van den Berg, Roderick L. Beijersbergen, René H. Medema, Bas van Steensel
Molecular Cell, 2021, vol. 81, p.2216-2230.e10
Hi-C analyses with GENOVA Robin H van der Weide, Teun van den Brand, Judith H I Haarhuis, Hans Teunissen, Benjamin D Rowland, Elzo de Wit
NAR genomics and bioinformatics, 2021, vol. 3
High-throughput identification of human SNPs affecting regulatory element activity Joris van Arensbergen, Ludo Pagie, Vincent D. FitzPatrick, Marcel de Haas, Marijke P. Baltissen, Federico Comoglio, Robin H. van der Weide, Hans Teunissen, Urmo Võsa, Lude Franke, Elzo de Wit, Michiel Vermeulen, Harmen J. Bussemaker, Bas van Steensel
Nature genetics, 2019, vol. 51, p.1160-1169

Fellowships & Awards

2024 - UitZicht Pilot Grant
2023 - NWO VENI Fellowship
2021 - GOA Young Investigator Award