Robert Jan Lebbink

Associate Professor

Strategic program(s):

Contact

rlebbin2@umcutrecht.nl

Pure profile

Research groups

Virus-host interactions

Research aim

To uncover new mechanisms of virus-host interactions and develop innovative antiviral strategies using genome engineering technologies.

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Recent publications

All publications

Genome-wide CRISPR/Cas9 library screen identifies C16orf62 as a host dependency factor for porcine deltacoronavirus infection Ningning Ma, Mengjia Zhang, Jiaru Zhou, Changsheng Jiang, Ahmed H. Ghonaim, Yumei Sun, Pei Zhou, Guanghao Guo, Anouk Evers, Hongmei Zhu, Qigai He, Robert Jan Lebbink, Berend Jan Bosch, Wentao Li
Emerging microbes & infections, 2024, vol. 13

CRISPR/Cas9-mediated genome editing of the thymidine kinase gene in a clinical HSV-1 isolate identifies F289S as novel acyclovir-resistant mutation Shuxuan Zheng, Georges M.G.M. Verjans, Anouk Evers, Ellen van den Wittenboer, Jeroen H.T. Tjhie, Robert Snoeck, Emmanuel J.H.J. Wiertz, Graciela Andrei, Jeroen J.A. van Kampen, Robert Jan Lebbink
Antiviral Research, 2024, vol. 228

The purinergic receptor P2X7 as a modulator of viral vector-mediated antigen cross-presentation Ylenia Longo, Sara Moreno Mascaraque, Giuseppe Andreacchio, Julia Werner, Ichiro Katahira, Elena De Marchi, Anna Pegoraro, Robert Jan Lebbink, Karl Köhrer, Patrick Petzsch, Ronny Tao, Francesco Di Virgilio, Elena Adinolfi, Ingo Drexler
Frontiers in Immunology, 2024, vol. 15

Proinsulin degradation and presentation of a proinsulin B-chain autoantigen involves ER-associated protein degradation (ERAD)-enzyme UBE2G2 Tom Cremer, Hanneke Hoelen, Michael L van de Weijer, George M Janssen, Ana I Costa, Peter A van Veelen, Robert Jan Lebbink, Emmanuel J H J Wiertz
PLoS ONE, 2024, vol. 19

Reactivation of Multidrug-Resistant HSV-1 in a Post-Allogenic Hematopoietic Stem Cell Transplant Patient Shuxuan Zheng, Lidewij L.W. Rümke, Bruno Tello Rubio, Malbert R.C. Rogers, Geerte L. Van Sluis, Jürgen H.E. Kuball, Annelies Riezebos-Brilman, Robert Jan Lebbink, Frans M. Verduyn Lunel
Open Forum Infectious Diseases, 2024, vol. 11

The genomic evolutionary dynamics and global circulation patterns of respiratory syncytial virus Annefleur C Langedijk, Bram Vrancken, Robert Jan Lebbink, Deidre Wilkins, Elizabeth J Kelly, Eugenio Baraldi, Abiel Homero Mascareñas de Los Santos, Daria M Danilenko, Eun Hwa Choi, María Angélica Palomino, Hsin Chi, Christian Keller, Robert Cohen, Jesse Papenburg, Jeffrey Pernica, Anne Greenough, Peter Richmond, Federico Martinón-Torres, Terho Heikkinen, Renato T Stein, Mitsuaki Hosoya, Marta C Nunes, Charl Verwey, Anouk Evers, Leyla Kragten-Tabatabaie, Marc A Suchard, Sergei L Kosakovsky Pond, Chiara Poletto, Vittoria Colizza, Philippe Lemey, Louis J Bont,
Nature Communications, 2024, vol. 15