Robert Jan Lebbink

Associate Professor

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Research aim

To uncover new mechanisms of virus-host interactions and develop innovative antiviral strategies using genome engineering technologies.

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Multi-proteomic profiling of the varicella-zoster virus-host interface reveals host susceptibilities to severe infection Virginie Girault, Alexey Stukalov, Madalina Elena Carter-Timofte, Jonny Hertzog, Melissa Verin, Katharina Austen, Darya A Haas, Lila Oubraham, Antonio Piras, Susanne Maidl, Rupert Öllinger, Roland Rad, Ulrike Protzer, Benedikt B Kaufer, Robert J Lebbink, Jan Rehwinkel, Trine H Mogensen, Andreas Pichlmair
Nature Microbiology, 2025, vol. 10, p.2048-2072

Identification of β4GALNT2 as an anti-hPIV3 factor through genome-wide CRISPR/Cas9 library screening Xuesheng Wu, Rutger D Luteijn, Estefanía Lozano-Andrés, Katherine Marougka, Wentao Li, Yoshiki Narimatsu, Frank J M van Kuppeveld, Berend Jan Bosch, Robert Jan Lebbink, Erik de Vries, Cornelis A M de Haan
Emerging microbes & infections, 2025, vol. 14

Genome-wide CRISPR/Cas9 library screen identifies C16orf62 as a host dependency factor for porcine deltacoronavirus infection Ningning Ma, Mengjia Zhang, Jiaru Zhou, Changsheng Jiang, Ahmed H. Ghonaim, Yumei Sun, Pei Zhou, Guanghao Guo, Anouk Evers, Hongmei Zhu, Qigai He, Robert Jan Lebbink, Berend Jan Bosch, Wentao Li
Emerging microbes & infections, 2024, vol. 13

CRISPR/Cas9-mediated genome editing of the thymidine kinase gene in a clinical HSV-1 isolate identifies F289S as novel acyclovir-resistant mutation Shuxuan Zheng, Georges M.G.M. Verjans, Anouk Evers, Ellen van den Wittenboer, Jeroen H.T. Tjhie, Robert Snoeck, Emmanuel J.H.J. Wiertz, Graciela Andrei, Jeroen J.A. van Kampen, Robert Jan Lebbink
Antiviral Research, 2024, vol. 228

The purinergic receptor P2X7 as a modulator of viral vector-mediated antigen cross-presentation Ylenia Longo, Sara Moreno Mascaraque, Giuseppe Andreacchio, Julia Werner, Ichiro Katahira, Elena De Marchi, Anna Pegoraro, Robert Jan Lebbink, Karl Köhrer, Patrick Petzsch, Ronny Tao, Francesco Di Virgilio, Elena Adinolfi, Ingo Drexler
Frontiers in Immunology, 2024, vol. 15

Proinsulin degradation and presentation of a proinsulin B-chain autoantigen involves ER-associated protein degradation (ERAD)-enzyme UBE2G2 Tom Cremer, Hanneke Hoelen, Michael L van de Weijer, George M Janssen, Ana I Costa, Peter A van Veelen, Robert Jan Lebbink, Emmanuel J H J Wiertz
PLoS ONE, 2024, vol. 19