Profile photo Raymond Schiffelers

Raymond Schiffelers

Full Professor

Strategic program(s):

Biography

Raymond Schiffelers studied Bio-Pharmaceutical Sciences at Leiden University (1990-1995). After an industrial traineeship at SmithKline Beecham Pharmaceuticals (UK) he did his PhD in medical microbiology at Erasmus University Rotterdam on liposomal targeting of antimicrobial agents (1996-2001). Subsequently he became post-doc at Utrecht University working on liposomes targeting tumor vasculature. In 2002-2003, at Intradigm Co (USA) he expanded his tumor vasculature-targeting work with polymers for delivery of siRNA. After his return to Utrecht University he became assistant and then associate professor. He co-invented OncoCort® a nanomedicine formulation of corticosteroids that will enter clinical trials in 2015.  In 2011, he moved to the Laboratory for Clinical Chemistry & Hematology of the University Medical Center Utrecht to work on nanomedicines, both for diagnosis and therapy. In particularly, he focuses on extracellular vesicles in the circulation as inspiration for new drug delivery systems and diagnostic readouts. He is founding member of the International Society for Extracellular Vesicles (ISEV) founding member and member organizing committee for the ISEV2014-annual meeting, Associate Editor of the Journal Extracellular Vesicles and editor of the International Journal of Pharmaceutics and the Journal of Controlled Release. He is Founder of EXCYTEX-an extracellular vesicle-based company and member of the Scientific Advisory Board for a number of start-up companies.

 

Research groups

Nanomedicine lab

Research aim

We develop synthetic and biological nanomedicine for targeted drug delivery

Go to group

Recent publications

GEVSod2 Powder Xiao Zhang, Xuan Ye, Yuling Xie, Zijiang Yang, Michail Spanos, Zilin Guo, Yu Xin Jin, Guoping Li, Zhiyong Lei, Raymond M. Schiffelers, Joost P.G. Sluijter, Hongyun Wang, Huihua Chen, Junjie Xiao
Research, 2025, vol. 8
Correction to Juntao Fang, Qiangbing Yang, Renée G.C. Maas, Michele Buono, Bram Meijlink, Dyonne Lotgerink Bruinenberg, Ernest Diez Benavente, Michal Mokry, Alain van Mil, Li Qian, Marie‑José Goumans, Raymond Schiffelers, Zhiyong Lei, Joost P.G. Sluijter
Stem Cell Research and Therapy, 2024, vol. 15
Intratumoral delivery of lipid nanoparticle-formulated mRNA encoding IL-21, IL-7, and 4-1BBL induces systemic anti-tumor immunity Ahmed E.I. Hamouda, Jessica Filtjens, Elisabeth Brabants, Daliya Kancheva, Ayla Debraekeleer, Jan Brughmans, Lotte Jacobs, Pauline M.R. Bardet, Elisabeth Knetemann, Pierre Lefesvre, Lize Allonsius, Mark Gontsarik, Ismael Varela, Marian Crabbé, Emile J. Clappaert, Federica Cappellesso, Aarushi A. Caro, Alícia Gordún Peiró, Luna Fredericq, Eva Hadadi, Mariona Estapé Senti, Raymond Schiffelers, Leo A. van Grunsven, Frank Aboubakar Nana, Bruno G. De Geest, Sofie Deschoemaeker, Stefaan De Koker, Florence Lambolez, Damya Laoui
Nature Communications, 2024, vol. 15
Lipid nanoparticles for nucleic acid delivery beyond the liver Nadine Saber, Mariona Estape Senti, Raymond Michel Schiffelers
Human gene therapy, 2024, vol. 35, p.617-627
Biofluid specific protein coronas affect lipid nanoparticle behavior in vitro Demian van Straten, Helena Sork, Luuk van de Schepop, Rowan Frunt, Kariem Ezzat, Raymond M. Schiffelers
Journal of Controlled Release, 2024, vol. 373, p.481-492
A magnetic separation method for isolating and characterizing the biomolecular corona of lipid nanoparticles Valentina Francia, Yao Zhang, Miffy Hok Yan Cheng, Raymond M Schiffelers, Dominik Witzigmann, Pieter R Cullis
Proceedings of the National Academy of Sciences of the United States of America, 2024, vol. 121

Fellowships & Awards

Vidi 2007 ‘Targeting inflammation to fight cancer’

Galenus Research Award 2009

ERC Consolidator grant 2010 260627 ‘Microvesicle-inspired drug delivery systems’

ERC Proof of Concept grant 2012 29744 ‘TargetMV’

External positions

Binnen Nanocell Therapeutics heb ik de functie van VP Preclinical R&D - supervisie onderzoekers op het gebied van preklinische R&D van nanomedicines - Nanocell Therapeutics

Editor - Blad op mijn vakgebied - Journal of Controlled Release

president ETPN - strategie in europees nanomedicine onderzoek - European Technology Platform Nanomedicine

Scientific Advisory Board - bedrijf ontwikkelt producten op mijn vakgebied - SentryX bv

associate editor - publicatie op mijn vakgebied - Drug Delivery & Translational Research

Scientific Advisory Board - Bedrijf ontwikkelt nanodeeltjes - Anjarium BioSciences

editor - publicatie op mijn vakgebied - International Journal of Pharmaceutics

associate editor - blad op mijn vakgebied - Journal Extracellular Vesicles

Chief Scientific Officer - Wetenschappelijke ontwikkelingen signaleren en onderzoeksstrategie bepalen - Excytex bv