Profile photo Raymond Schiffelers

Raymond Schiffelers

Full Professor

Strategic program(s):

Biography

Raymond Schiffelers studied Bio-Pharmaceutical Sciences at Leiden University (1990-1995). After an industrial traineeship at SmithKline Beecham Pharmaceuticals (UK) he did his PhD in medical microbiology at Erasmus University Rotterdam on liposomal targeting of antimicrobial agents (1996-2001). Subsequently he became post-doc at Utrecht University working on liposomes targeting tumor vasculature. In 2002-2003, at Intradigm Co (USA) he expanded his tumor vasculature-targeting work with polymers for delivery of siRNA. After his return to Utrecht University he became assistant and then associate professor. He co-invented OncoCort® a nanomedicine formulation of corticosteroids that will enter clinical trials in 2015.  In 2011, he moved to the Laboratory for Clinical Chemistry & Hematology of the University Medical Center Utrecht to work on nanomedicines, both for diagnosis and therapy. In particularly, he focuses on extracellular vesicles in the circulation as inspiration for new drug delivery systems and diagnostic readouts. He is founding member of the International Society for Extracellular Vesicles (ISEV) founding member and member organizing committee for the ISEV2014-annual meeting, Associate Editor of the Journal Extracellular Vesicles and editor of the International Journal of Pharmaceutics and the Journal of Controlled Release. He is Founder of EXCYTEX-an extracellular vesicle-based company and member of the Scientific Advisory Board for a number of start-up companies.

 

Research groups

Nanomedicine lab

Research aim

We develop synthetic and biological nanomedicine for targeted drug delivery

Go to group

Recent publications

T cell-specific non-viral DNA delivery and in vivo CAR-T generation using targeted lipid nanoparticles Jaime Fernández Bimbo, Eline van Diest, Daniel E. Murphy, Ator Ashoti, Martijn J.W. Evers, Suneel A. Narayanavari, Diana Pereira Vaz, Hanneke Rijssemus, Christina Zotou, Nadine Saber, Zhiyong Lei, Peter Mayrhofer, Maurits Geerlings, Raymond Schiffelers, Jacek Lubelski
Journal for ImmunoTherapy of Cancer, 2025, vol. 13
Effective communication with JCR editors in the peer review process Honggang Cui, Ana Beloqui, Davide Brambilla, Paolo Caliceti, Yunching (Becky) Chen, Laura M. Ensign, Jong Oh Kim, Twan Lammers, Kanjiro Miyata, Yu Kyoung Oh, Dan Peer, Amirali Popat, Raymond Schiffelers, Yang Shi, Xun Sun, Pieter Vader, Yoon Yeo, Lichen Yin, Yu Seok Youn, Zhiyuan Zhong, Stefaan C. De Smedt
Journal of Controlled Release, 2025, vol. 385
Serum heat inactivation diminishes ApoE-mediated uptake of D-Lin-MC3-DMA lipid nanoparticles Demian van Straten, Luuk van de Schepop, Rowan Frunt, Pieter Vader, Raymond M Schiffelers
Beilstein journal of nanotechnology, 2025, vol. 16, p.740-748
Therapeutic Application of mRNA for Genetic Diseases Paul J.L. Schürmann, Stijn P.E. van Breda Vriesman, Jose A. Castro-Alpízar, Sander A.A. Kooijmans, Edward E.S. Nieuwenhuis, Raymond M. Schiffelers, Sabine A. Fuchs
Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2025, vol. 17
Incorporation of cellular membrane protein extracts into lipid nanoparticles enhances their cellular uptake and mRNA delivery efficiency Diego A Rodríguez, Gaspard P R Lefebvre, Qiangbing Yang, Arjan D Barendrecht, Cor W Seinen, Raymond M Schiffelers, Pieter Vader
Journal of controlled release : official journal of the Controlled Release Society, 2025, vol. 382
A Robust Post-Insertion Method for the Preparation of Targeted Lipid Nanoparticles Jaime Fernández Bimbo, Raymond Schiffelers
Methods in molecular biology (Clifton, N.J.), 2025, vol. 2901, p.241-250

Fellowships & Awards

Vidi 2007 ‘Targeting inflammation to fight cancer’

Galenus Research Award 2009

ERC Consolidator grant 2010 260627 ‘Microvesicle-inspired drug delivery systems’

ERC Proof of Concept grant 2012 29744 ‘TargetMV’

External positions

Binnen Nanocell Therapeutics heb ik de functie van VP Preclinical R&D - supervisie onderzoekers op het gebied van preklinische R&D van nanomedicines - Nanocell Therapeutics

Editor - Blad op mijn vakgebied - Journal of Controlled Release

president ETPN - strategie in europees nanomedicine onderzoek - European Technology Platform Nanomedicine

Scientific Advisory Board - bedrijf ontwikkelt producten op mijn vakgebied - SentryX bv

associate editor - publicatie op mijn vakgebied - Drug Delivery & Translational Research

Scientific Advisory Board - Bedrijf ontwikkelt nanodeeltjes - Anjarium BioSciences

editor - publicatie op mijn vakgebied - International Journal of Pharmaceutics

associate editor - blad op mijn vakgebied - Journal Extracellular Vesicles

Chief Scientific Officer - Wetenschappelijke ontwikkelingen signaleren en onderzoeksstrategie bepalen - Excytex bv