Profile photo Raymond Schiffelers

Raymond Schiffelers

Full Professor

Strategic program(s):

Biography

Raymond Schiffelers studied Bio-Pharmaceutical Sciences at Leiden University (1990-1995). After an industrial traineeship at SmithKline Beecham Pharmaceuticals (UK) he did his PhD in medical microbiology at Erasmus University Rotterdam on liposomal targeting of antimicrobial agents (1996-2001). Subsequently he became post-doc at Utrecht University working on liposomes targeting tumor vasculature. In 2002-2003, at Intradigm Co (USA) he expanded his tumor vasculature-targeting work with polymers for delivery of siRNA. After his return to Utrecht University he became assistant and then associate professor. He co-invented OncoCort® a nanomedicine formulation of corticosteroids that will enter clinical trials in 2015.  In 2011, he moved to the Laboratory for Clinical Chemistry & Hematology of the University Medical Center Utrecht to work on nanomedicines, both for diagnosis and therapy. In particularly, he focuses on extracellular vesicles in the circulation as inspiration for new drug delivery systems and diagnostic readouts. He is founding member of the International Society for Extracellular Vesicles (ISEV) founding member and member organizing committee for the ISEV2014-annual meeting, Associate Editor of the Journal Extracellular Vesicles and editor of the International Journal of Pharmaceutics and the Journal of Controlled Release. He is Founder of EXCYTEX-an extracellular vesicle-based company and member of the Scientific Advisory Board for a number of start-up companies.

 

Research groups

Nanomedicine lab

Research aim

We develop synthetic and biological nanomedicine for targeted drug delivery

Go to group

Recent publications

Assessment of feto-placental oxygenation and perfusion in a rat model of placental insufficiency using T2* mapping and 3D dynamic contrast-enhanced MRI Fatimah M. Al Darwish, Bram F. Coolen, Caren M. van Kammen, Lindy K. Alles, Judith de Vos, Raymond M. Schiffelers, Titia A. Lely, Gustav J. Strijkers, Fieke Terstappen
Placenta, 2024, vol. 151, p.19-25
mRNA-LNP COVID-19 Vaccine Lipids Induce Complement Activation and Production of Proinflammatory Cytokines Tamás Bakos, Tamás Mészáros, Gergely Tibor Kozma, Petra Berényi, Réka Facskó, Henriette Farkas, László Dézsi, Carlo Heirman, Stefaan de Koker, Raymond Schiffelers, Kathryn Anne Glatter, Tamás Radovits, Gábor Szénási, János Szebeni
International Journal of Molecular Sciences, 2024, vol. 25
Cardiac delivery of modified mRNA using lipid nanoparticles M C I Labonia, M Estapé Senti, P H van der Kraak, M A D Brans, I Dokter, T J Streef, A M Smits, A K Deshantri, S C A de Jager, R M Schiffelers, J P G Sluijter, P Vader
Journal of controlled release : official journal of the Controlled Release Society, 2024, vol. 369, p.734-745
A magnetic separation method for isolating and characterizing the biomolecular corona of lipid nanoparticles Valentina Francia, Yao Zhang, Miffy Hok Yan Cheng, Raymond M Schiffelers, Dominik Witzigmann, Pieter R Cullis
Proceedings of the National Academy of Sciences of the United States of America, 2024, vol. 121
Lipid nanoparticles for nucleic acid delivery beyond the liver Nadine Saber, Mariona Estape Senti, Raymond Michel Schiffelers
Human gene therapy, 2024, vol. 35, p.617-627
Vitamin C facilitates direct cardiac reprogramming by inhibiting reactive oxygen species Juntao Fang, Qiangbing Yang, Renée G C Maas, Michele Buono, Bram Meijlink, Dyonne Lotgerink Bruinenberg, Ernest Diez Benavente, Michal Mokry, Alain van Mil, Li Qian, Marie-José Goumans, Raymond Schiffelers, Zhiyong Lei, Joost P G Sluijter
Stem Cell Research & Therapy [E], 2024, vol. 15, p.19

Fellowships & Awards

2021: NWA-ORC: NANOSPRESSO-NL: op maat gemaakte gepersonaliseerde geneesmiddelen versus grootschalige industriële productie van geneesmiddelen

External positions

Jury lid - beoordelen subsidie-aanvragen - Agence National de Recherche

Binnen Nanocell Therapeutics heb ik de functie van VP Preclinical R&D - supervisie onderzoekers op het gebied van preklinische R&D van nanomedicines - Nanocell Therapeutics

Editor - Blad op mijn vakgebied - Journal of Controlled Release

president ETPN - strategie in europees nanomedicine onderzoek - European Technology Platform Nanomedicine

Scientific Advisory Board - bedrijf ontwikkelt producten op mijn vakgebied - SentryX bv

associate editor - publicatie op mijn vakgebied - Drug Delivery & Translational Research

Scientific Advisory Board - Bedrijf ontwikkelt nanodeeltjes - Anjarium BioSciences

editor - publicatie op mijn vakgebied - International Journal of Pharmaceutics

associate editor - blad op mijn vakgebied - Journal Extracellular Vesicles

Chief Scientific Officer - Wetenschappelijke ontwikkelingen signaleren en onderzoeksstrategie bepalen - Excytex bv