Profile photo Raymond Schiffelers

Raymond Schiffelers

Full Professor

Strategic program(s):

Biography

Raymond Schiffelers studied Bio-Pharmaceutical Sciences at Leiden University (1990-1995). After an industrial traineeship at SmithKline Beecham Pharmaceuticals (UK) he did his PhD in medical microbiology at Erasmus University Rotterdam on liposomal targeting of antimicrobial agents (1996-2001). Subsequently he became post-doc at Utrecht University working on liposomes targeting tumor vasculature. In 2002-2003, at Intradigm Co (USA) he expanded his tumor vasculature-targeting work with polymers for delivery of siRNA. After his return to Utrecht University he became assistant and then associate professor. He co-invented OncoCort® a nanomedicine formulation of corticosteroids that will enter clinical trials in 2015.  In 2011, he moved to the Laboratory for Clinical Chemistry & Hematology of the University Medical Center Utrecht to work on nanomedicines, both for diagnosis and therapy. In particularly, he focuses on extracellular vesicles in the circulation as inspiration for new drug delivery systems and diagnostic readouts. He is founding member of the International Society for Extracellular Vesicles (ISEV) founding member and member organizing committee for the ISEV2014-annual meeting, Associate Editor of the Journal Extracellular Vesicles and editor of the International Journal of Pharmaceutics and the Journal of Controlled Release. He is Founder of EXCYTEX-an extracellular vesicle-based company and member of the Scientific Advisory Board for a number of start-up companies.

 

Research groups

Nanomedicine lab

Research aim

We develop synthetic and biological nanomedicine for targeted drug delivery

Go to group

Recent publications

Enhancing cardiomyocyte reprogramming efficiency by targeting cellular senescence is mediated via Rb1 gene Juntao Fang, Qiangbing Yang, Renée G.C. Maas, Pieter Vader, Michal Mokry, Noortje A.M. van den Dungen, Li Qian, Junjie Xiao, Raymond Schiffelers, Zhiyong Lei, Joost P.G. Sluijter
Stem Cell Research and Therapy, 2025, vol. 16
Hybrid Extracellular Vesicles for Efficient Loading and Functional Delivery of mRNA Xiaoqin Wang, Michael J Munson, Kristina Friis, Anna Marzeda, Andreia M Silva, Franziska Kohl, Leif Hultin, Raymond M Schiffelers, Niek Dekker
Journal of Extracellular Vesicles, 2025, vol. 14
A modular strategy for extracellular vesicle-mediated CRISPR-Cas9 delivery through aptamer-based loading and UV-activated cargo release Omnia M Elsharkasy, Charlotte V Hegeman, Tom A P Driedonks, Xiuming Liang, Ivana Lansweers, Olaf L Cotugno, Ingmar Y de Groot, Zoë E M N J de Wit, Antonio Garcia-Guerra, Niels J A Moorman, Sjoerd H Boonstra, Esmeralda D C Bosman, Juliet W Lefferts, Willemijn S de Voogt, Jerney J François, Annet C W van Wesel, Samir El Andaloussi, Raymond M Schiffelers, Sander A A Kooijmans, Enrico Mastrobattista, Pieter Vader, Olivier G de Jong
Nature Communications, 2025, vol. 16
The liver talks back Laura Wormser, Valerie Fritz, Melanie Kappelmann-Fenzl, Nicole Rachinger, Pol Escudé, Karin Enderle, Matthias D Kaufmann, Miriam Düll, Abdo Mahli, Sebastian Zundler, Moritz Leppkes, Stefan Fischer, Felix Elsner, Carol-Immanuel Geppert, Michael Hannus, Susanne Merkel, Michael Erdmann, Claudia Günther, Katja Evert, Zubeir El Ahmad, Gunter Meister, Elisabetta D'Avanzo, Marc P Stemmler, Clemens Neufert, Andreas E Kremer, Georg F Weber, Thomas Brabletz, Stephan von Hörsten, Reiner Wiest, Raymond Schiffelers, Arndt Hartmann, Jürgen Siebler, Jonel Trebicka, Maximilian Waldner, Markus F Neurath, Claus Hellerbrand, Anja K Bosserhoff, Peter Dietrich
Proceedings of the National Academy of Sciences of the United States of America, 2025, vol. 122, p.1-12
Targeted inhibition of hepatic de novo ceramide synthesis ameliorates MASH Xiaodong Yu, Chenyuan Huang, Martijn Evers, Jingjing Liu, Hui Jun Ting, Sitong Zhang, Suet Yen Chong, Michelle Siying Tan, Siyu Wang, Nilofer Sayed, Liang Gao, Mark D. Muthiah, Gwyneth S.T. Soon, Aileen Wee, Edward Kai Hua Chow, Natalie Jun Hui Soh, Giorgia Pastorin, Victor C. Yu, Bin Liu, Yock Young Dan, Federico Torta, Raymond Schiffelers, Gert Storm, Jiong Wei Wang
Science advances, 2025, vol. 11
T cell-specific non-viral DNA delivery and in vivo CAR-T generation using targeted lipid nanoparticles Jaime Fernández Bimbo, Eline van Diest, Daniel E. Murphy, Ator Ashoti, Martijn J.W. Evers, Suneel A. Narayanavari, Diana Pereira Vaz, Hanneke Rijssemus, Christina Zotou, Nadine Saber, Zhiyong Lei, Peter Mayrhofer, Maurits Geerlings, Raymond Schiffelers, Jacek Lubelski
Journal for immunotherapy of cancer, 2025, vol. 13

Fellowships & Awards

Vidi 2007 ‘Targeting inflammation to fight cancer’

Galenus Research Award 2009

ERC Consolidator grant 2010 260627 ‘Microvesicle-inspired drug delivery systems’

ERC Proof of Concept grant 2012 29744 ‘TargetMV’

External positions

Binnen Nanocell Therapeutics heb ik de functie van VP Preclinical R&D - supervisie onderzoekers op het gebied van preklinische R&D van nanomedicines - Nanocell Therapeutics

Editor - Blad op mijn vakgebied - Journal of Controlled Release

president ETPN - strategie in europees nanomedicine onderzoek - European Technology Platform Nanomedicine

Scientific Advisory Board - bedrijf ontwikkelt producten op mijn vakgebied - SentryX bv

associate editor - publicatie op mijn vakgebied - Drug Delivery & Translational Research

Scientific Advisory Board - Bedrijf ontwikkelt nanodeeltjes - Anjarium BioSciences

editor - publicatie op mijn vakgebied - International Journal of Pharmaceutics

associate editor - blad op mijn vakgebied - Journal Extracellular Vesicles

Chief Scientific Officer - Wetenschappelijke ontwikkelingen signaleren en onderzoeksstrategie bepalen - Excytex bv