Profile photo Geert Ramakers

Geert Ramakers

Associate Professor

Strategic program(s):

Biography

Geert Ramakers obtained his PhD degree in Utrecht (1995) with Willem Hendrik Gispen en Flaminio Catabeni (co promotores: Pierre de Graan and Ivan Urban). He performed postdoctoral research in Utrecht (1995 – 1997) at the department of Neuroscience and Anatomy and Oslo (1998 – 2000) at the department of Physiology. In 2000 he was appointed at the UMC Utrecht as assistant professor at the department of Neuroscience and Pharmacology.

His research focusses on  cellular and synaptic plasticity; he wants to know how neurons integrate synaptic signals and convert these signals into output signals (action potentials). Research focusses on two brain areas: the hippocampus and the midbrain dopamine system (ventral tegmental area and striatum). Whole cell patch-clamp and field potential recordings in vitro, in vivo electrophysiology and optogenetic approaches are primarily used to study these phenomena.

Plasticity of neural circuits plays an important role during development, learning and ongoing behaviour. Plasticity of neural systems can result from alterations in synaptic strength, as well as changes in neuronal excitability. Unraveling the mechanisms underlying plasticity is fundamental in understanding the physiology of learning and memory and pathophysiology of neurological diseases (e.g. addiction). The aim of his research is to delineate specific processes involved in synaptic and cellular plasticity and eventually the role of these processes in physiological and pathophysiological conditions. 

In addition to his research efforts, Geert is also coordinator of the master program Neuroscience and Cognition and the neurotrack within the bachelor Biomedical Sciences.

Research line

Cellular and Synaptic Plasticity

Most recent key publications

1: Jongbloets, B. C., Ramakers, G. M. J. & Pasterkamp, R. J. (2013) Semaphorin7A and its receptors: Pleiotropic regulators of immune cell function, bone homeostasis, and neural development. Seminars in Cell and Developmental Biology 1–36. doi:10.1016/j.semcd
2: Meye, F. J., van Zessen, R., Smidt, M. P., Adan, R. A. H. & Ramakers, G. M. J. (2012) Morphine Withdrawal Enhances Constitutive µ-Opioid Receptor Activity in the Ventral Tegmental Area. Journal of Neuroscience 32, 16120–16128
3: Meye, F. J., Trezza, V., Vanderschuren, L. J. M. J., Ramakers, G. M. J. & Adan, R. A. H. (2012) Neutral antagonism at the cannabinoid 1 receptor: a safer treatment for obesity. Mol. Psych. doi:10.1038/mp.2012.145
4: Notenboom, R. G. E., Ramakers, G. M. J., Kamal, A., Spruijt, B. M. & De Graan, P. N. E. (2010) Long-lasting modulation of synaptic plasticity in rat hippocampus after early-life complex febrile seizures. European Journal of Neuroscience 32, 749–758
5: Hoogendam JM, Ramakers GM, Di Lazarro V (2010) Physiology of repetitive transcranial magnetic stimulation of the human brain. Brain Stim. 3, 95-118

Research groups

Teaching team Translational Neuroscience

Research aim

Our teaching mission is to raise the next generation scientists and clinicians with state-of-the-art knowledge, technical expertise and vision in the field of neuroscience and pharmacology.

Go to group

Recent publications

Baclofen and naltrexone, but not N-acetylcysteine, affect voluntary alcohol drinking in rats regardless of individual levels of alcohol intake A Maryse Minnaard, Geert M J Ramakers, Louk J M J Vanderschuren, Heidi M B Lesscher
Behavioural Pharmacology, 2021, vol. 32, p.251-257
Keuzevrijheid voor master studenten: van last tot lust Rianne Bouwmeester, Shirrinka Goubitz, Mieke Lumens, Geert Ramakers, Scager K, G Dilaver
Onderzoek van Onderwijs, 2020, vol. 49, p.12
Stage-specific functions of Semaphorin7A during adult hippocampal neurogenesis rely on distinct receptors Bart C. Jongbloets, Suzanne Lemstra, Roberta Schellino, Mark H. Broekhoven, Jyoti Parkash, Anita J C G M Hellemons, Tianyi Mao, Paolo Giacobini, Henriette Van Praag, Silvia De Marchis, Geert M J Ramakers, R. Jeroen Pasterkamp
Nature Communications [E], 2017, vol. 8
Effects of neonatal exposure to the flame retardant tetrabromobisphenol-A, aluminum diethylphosphinate or zinc stannate on long-term potentiation and synaptic protein levels in mice Hester S. Hendriks, Lucas A. E. Koolen, Milou M. L. Dingemans, Henrik Viberg, Iwa Lee, Pim E. G. Leonards, Geert M. J. Ramakers, Remco H. S. Westerink
Archives of toxicology, 2015, vol. 89, p.2345-2354
Modulation of cue-induced firing of ventral tegmental area dopamine neurons by leptin and ghrelin Open G. Van Der Plasse, R. Van Zessen, M. C.M. Luijendijk, H. Erkan, G. D. Stuber, G. M.J. Ramakers, R. A.H. Adan
International Journal of Obesity, 2015, vol. 39, p.1742–1749
The vital role of constitutive GPCR activity in the mesolimbic dopamine system F.J. Meye, G.M.J. Ramakers, R.A.H. Adan
Translational Psychiatry [E], 2014, vol. 4

Fellowships & Awards

2019: Heijmans van den Bergh Education Prize