Profile photo Pim van der Harst

Pim van der Harst

Full Professor

Strategic program(s):

Biography

I am an interventional cardiologist and scientist and head of the department of cardiology of the University Medical Center Utrecht. My clinical work includes the percutaneous treatment of obstructive coronary artery disease, including acute myocardial infarction. My translational research focusses on the analysis of big and complex data (e.g. genetic, ehr, imaging), including the use of machine learning and cloud computing, to improve our understanding and the early detection of coronary artery disease and heart failure. To this end we use large population based cohorts, including the Dutch PREVEND and LifeLine cohorts and the UK Biobank. Data on my "omics" research can be found our my website: www.cardiomics.net  In my clinical translational research I am also working on advanced image analysis, device interventions, machine learning, deep learning, and e/m Health to further improve and personalize care for our patients. Currently ongoing diagnostic imaging studies in include the REPLACE-IT (replacement of invasive coronary angiography) and the EARLY-SYNERGY (early detection of obstructive coronary artery disease; www.early-synergy.nl) studies. Currently interventional studies include the GIPS-IV, AXES and MRI-MC studies. Many of my projects based on collaborations with the most influential and creative individuals and research groups in the world.

Research groups

Inherited heart disease (cardiogenetics)

Research aim

We aim to enhance patient and family lives impacted by inherited cardiomyopathies. Our efforts target gene and variant identification, disease mechanisms, factors influencing disease outcomes, therapy optimization, and exploration of novel therapies.

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Recent publications

Ischemia during exercise stress testing, an indication of coronary vasomotor dysfunction? Diantha J.M. Schipaanboord, Tijn P.J. Jansen, Luuk Scherpenhuijzen, Caïa Crooijmans, Aukelien C. Dimitriu-Leen, Pim van der Harst, Tim P. van de Hoef, René van Es, Hester M. den Ruijter, Peter Damman, N. Charlotte Onland-Moret, Suzette E. Elias-Smale
IJC Heart and Vasculature, 2025, vol. 56
Location-specific prognostic significance of plaque burden, stenosis, and plaque morphology in coronary artery disease Ruurt A. Jukema, Teemu Maaniitty, Nick S. Nurmohamed, Pieter G. Raijmakers, R. Nils Planken, Jos Twisk, Pim van der Harst, Maarten J. Cramer, James K. Min, James P. Earls, Paul Knaapen, Antti Saraste, Juhani Knuuti, Ibrahim Danad
European heart journal. Cardiovascular Imaging, 2025, vol. 26, p.22-29
Left atrial strain predicts long-term heart failure outcomes after ST-elevation myocardial infarction Kim W.L.M. Ricken, Chris Lenselink, Constantijn S. Venema, Iwan C.C. van der Horst, Pim van der Harst, Gabija Pundziute-Do Prado, Adriaan A. Voors, Erik Lipsic
International Journal of Cardiology, 2025, vol. 422
Importance of early use of tolvaptan in hyponatremic acutely decompensated heart failure patients, a retrospective study Rarsari Soerarso, Emir Yonas, Silfi Pauline Sirait, Dian Yaniarti Hasanah, Sunu Budhi Raharjo, Bambang Budi Siswanto, Maarten J Cramer, Pim van der Harst, Marish I F J Oerlemans
The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology, 2025, vol. 77
Measuring health-related quality of life in cardiovascular disease using a novel patient-centred and disease-specific patient-reported outcome measure Tajinder K. Singh, Daan Ties, Hilde E. Groot, Paul F.M. Krabbe, Pim van der Harst
International Journal of Cardiology: Cardiovascular Risk and Prevention, 2025, vol. 24
A genetic association study of circulating coagulation factor VIII and von Willebrand factor levels Paul S. de Vries, Paula Reventun, Michael R. Brown, Adam S. Heath, Jennifer E. Huffman, Ngoc Quynh Le, Allison Bebo, Jennifer A. Brody, Gerard Temprano-Sagrera, Laura M. Raffield, Ayse Bilge Ozel, Florian Thibord, Deepti Jain, Joshua P. Lewis, Benjamin A.T. Rodriguez, Nathan Pankratz, Kent D. Taylor, Ozren Polasek, Ming Huei Chen, Lisa R. Yanek, German D. Carrasquilla, Riccardo E. Marioni, Marcus E. Kleber, David Alexandre Trégouët, Jie Yao, Ruifang Li-Gao, Peter K. Joshi, Stella Trompet, Angel Martinez-Perez, Mohsen Ghanbari, Tom E. Howard, Alex P. Reiner, Marios Arvanitis, Kathleen A. Ryan, Traci M. Bartz, Igor Rudan, Nauder Faraday, Allan Linneberg, Lynette Ekunwe, Gail Davies, Graciela E. Delgado, Pierre Suchon, Xiuqing Guo, Frits R. Rosendaal, Lucija Klaric, Raymond Noordam, Frank van Rooij, Joanne E. Curran, Marsha M. Wheeler, Pim van der Harst, ,
Blood, 2024, vol. 143, p.1845-1855

External positions

Editor-in-Chief - editor - bohn stafleu van loghum

Lid van de Raad van Toezicht - vele raakvlakken - Netherlands Heart Institute

begeleiden promovendi met afronden van hun promotie, eerste promotor - soortgelijk - Universitair Medisch Centrum Groningen

National member of Scientific Advisory Board LifeLines Cohort Study - ja, inhoudelijk advies - LifeLines B.V.

Nucleus member of the center for circulatory health at the UMC Utrecht - ja - UMC Utrecht

begeleiden promovendi met afronden van hun promotie, eerste promotor - soortgelijk - Universitair Medisch Centrum Groningen

National member of Scientific Advisory Board LifeLines Cohort Study - ja, inhoudelijk advies - LifeLines B.V.

Nucleus member of the center for circulatory health at the UMC Utrecht - ja - UMC Utrecht