Profile photo Pim van der Harst

Pim van der Harst

Full Professor

Strategic program(s):

Biography

I am an interventional cardiologist and scientist and head of the department of cardiology of the University Medical Center Utrecht. My clinical work includes the percutaneous treatment of obstructive coronary artery disease, including acute myocardial infarction. My translational research focusses on the analysis of big and complex data (e.g. genetic, ehr, imaging), including the use of machine learning and cloud computing, to improve our understanding and the early detection of coronary artery disease and heart failure. To this end we use large population based cohorts, including the Dutch PREVEND and LifeLine cohorts and the UK Biobank. Data on my "omics" research can be found our my website: www.cardiomics.net  In my clinical translational research I am also working on advanced image analysis, device interventions, machine learning, deep learning, and e/m Health to further improve and personalize care for our patients. Currently ongoing diagnostic imaging studies in include the REPLACE-IT (replacement of invasive coronary angiography) and the EARLY-SYNERGY (early detection of obstructive coronary artery disease; www.early-synergy.nl) studies. Currently interventional studies include the GIPS-IV, AXES and MRI-MC studies. Many of my projects based on collaborations with the most influential and creative individuals and research groups in the world.

Research groups

Inherited heart disease (cardiogenetics)

Research aim

We aim to enhance patient and family lives impacted by inherited cardiomyopathies. Our efforts target gene and variant identification, disease mechanisms, factors influencing disease outcomes, therapy optimization, and exploration of novel therapies.

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Recent publications

From guidelines to patient-centred action Pim van der Harst
Netherlands Heart Journal, 2025, vol. 33, p.215
Clinical relevance and outcome of routine endomyocardial biopsy to detect rejection after heart transplantation Leendert C Kieviet, Steven A Muller, Mariusz K Szymanski, Manon G van der Meer, M Louis Handoko, Saskia Z H Rittersma, Saskia C A de Jager, Egidius E van Aarnhem, Annelotte Vos, Pim van der Harst, Linda W van Laake, Marish I F J Oerlemans
JHLT Open, 2025, vol. 9
Microaxial flow pump in cardiogenic shock Jan-Willem Balder, Adriaan Kraaijeveld, Mariusz Szymanski, Linda van Laake, Einar Hart, Michiel Voskuil, Joep Droogh, Faiz Ramjankhan, Tim van de Hoef, Jeannine Hermens, Pim van der Harst, Kevin Damman, Erik Lipsic, Gabija Pundziute, Michael Dickinson
Netherlands Heart Journal, 2025, vol. 33, p.226–231
Uncovering cell type-specific phenotypes using a novel human in vitro model of transthyretin amyloid cardiomyopathy Jiabin Qin, Qiangbing Yang, Asier Ullate-Agote, Vasco Sampaio-Pinto, Laura Florit, Inge Dokter, Chrysoula Mathioudaki, Lotte Middelberg, Pilar Montero-Calle, Paula Aguirre-Ruiz, Joana de Las Heras Rojo, Zhiyong Lei, Zeping Qiu, Jin Wei, Pim van der Harst, Felipe Prosper, Manuel M Mazo, Olalla Iglesias-García, Monique C Minnema, Joost P G Sluijter, Marish I F J Oerlemans, Alain van Mil
Stem cell research & therapy, 2025, vol. 16
Erratum to ‘Model-Based Cost-Utility Analysis of Combined Low-Dose Computed Tomography Screening for Lung Cancer, Chronic Obstructive Pulmonary Disease, and Cardiovascular Disease’ [JTO Clinical and Research Reports Volume 6 Issue 5 (2025) 100813] (JTO Cl Carina M. Behr, Maarten J. IJzerman, Michelle M.A. Kip, Harry J.M. Groen, Marjolein A. Heuvelmans, Maarten van den Berge, Pim van der Harst, Marleen Vonder, Rozemarijn Vliegenthart, Hendrik Koffijberg
JTO clinical and research reports, 2025, vol. 6
Studies on ICD guidelines, cardiac amyloidosis in HFpEF, and remote monitoring outcomes Pim van der Harst
Netherlands Heart Journal, 2025, vol. 33, p.183

Fellowships & Awards

Awards

2015

Winner of Humanimal – One Health Innovation Challenge 2015 with the Durrer Center (of which I was Chief Scientific Officer). Price for “Best Professional Idea Flevoland” for our Open One Health Biobank proposal (€ 50,000.--)

2013Scientific Excellence Award from the Board of the UMCG (€ 100,000.--)
2010 Excellence Award from the Netherlands Foundation for Cardiovascular Excellence for Scientific, Clinical and Presenting Excellence (€ 50,000.--)

Fellowships

2012NWO Clinical Fellowship (90.700.441); Systems and functional genomics strategies to identify novel vulnerability genes for heart failure. €160,000.--
2007VENI Fellowship (916.76.170) of the Innovational Research Incentives Scheme of the Netherlands Organization for Scientific Research (NWO); Telomere length in cardiovascular disease; differential expression and prognostic value (€ 248,000.--)
2008ICIN Fellowship (€ 45,000.--) of the Interuniversity Cardiology Institute of the Netherlands

         

 

External positions

Editor-in-Chief - editor - bohn stafleu van loghum

Lid van de Raad van Toezicht - vele raakvlakken - Netherlands Heart Institute

begeleiden promovendi met afronden van hun promotie, eerste promotor - soortgelijk - Universitair Medisch Centrum Groningen

National member of Scientific Advisory Board LifeLines Cohort Study - ja, inhoudelijk advies - LifeLines B.V.

Nucleus member of the center for circulatory health at the UMC Utrecht - ja - UMC Utrecht

begeleiden promovendi met afronden van hun promotie, eerste promotor - soortgelijk - Universitair Medisch Centrum Groningen

National member of Scientific Advisory Board LifeLines Cohort Study - ja, inhoudelijk advies - LifeLines B.V.

Nucleus member of the center for circulatory health at the UMC Utrecht - ja - UMC Utrecht