Profile photo Pim van der Harst

Pim van der Harst

Full Professor

Strategic program(s):

Biography

I am an interventional cardiologist and scientist and head of the department of cardiology of the University Medical Center Utrecht. My clinical work includes the percutaneous treatment of obstructive coronary artery disease, including acute myocardial infarction. My translational research focusses on the analysis of big and complex data (e.g. genetic, ehr, imaging), including the use of machine learning and cloud computing, to improve our understanding and the early detection of coronary artery disease and heart failure. To this end we use large population based cohorts, including the Dutch PREVEND and LifeLine cohorts and the UK Biobank. Data on my "omics" research can be found our my website: www.cardiomics.net  In my clinical translational research I am also working on advanced image analysis, device interventions, machine learning, deep learning, and e/m Health to further improve and personalize care for our patients. Currently ongoing diagnostic imaging studies in include the REPLACE-IT (replacement of invasive coronary angiography) and the EARLY-SYNERGY (early detection of obstructive coronary artery disease; www.early-synergy.nl) studies. Currently interventional studies include the GIPS-IV, AXES and MRI-MC studies. Many of my projects based on collaborations with the most influential and creative individuals and research groups in the world.

Research groups

Inherited heart disease (cardiogenetics)

Research aim

We aim to enhance patient and family lives impacted by inherited cardiomyopathies. Our efforts target gene and variant identification, disease mechanisms, factors influencing disease outcomes, therapy optimization, and exploration of novel therapies.

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Recent publications

A genome- and phenome-wide association study of plasma procalcitonin concentrations in individuals of European ancestry Wenbo Zhang, Peter J. van der Most, Siqi Wang, Zoha Kamali, Alice Giontella, Sofia Enhörning, Ron T. Gansevoort, Pim van der Harst, Stephan J.L. Bakker, Olle Melander, Frederik Keus, Gerton Lunter, Harold Snieder
EBioMedicine, 2026, vol. 123
Myocardial infarction with nonobstructive coronary arteries - the European PERspective (SNIPER) survey Doralisa Morrone, Giulio Stefanini, Marco De Carlo, Cristina Giannini, Gabor Toth, Dan Prunea, Carlo Zivelonghi, Alice Benedetti, Bernard De Bruyne, Adriaan Wilgenhof, Jan Kanovsky, Petr Kala, Lene Holmvang, Markus Hasbak, David Hildick-Smith, James Cockburn, Nicolas Amabile, Aurelie Veugeois, Thomas Hovasse, Antoinette Neylon, Benjamin Honton, Bruno Farah, Tommaso Gori, Maike Knorr, Alexander Wolf, Thomas Schmit, Jörg Hausleiter, Konstantin Stark K, Mohamed Abdel-Waha, Hans Josef Feistritzer, Felix Woitek, Axel Linke, Jürgen Leick, Shazia Afzal, Dimitrios Alexopoulos, Charalampos Varlamos, Kostantinos Tsioufis, Kyriakos Dimitriadis, Luca Testa, Mattia Squillace, Federico Conrotto, Fabrizio D'Ascenzo, Gianluca Campo, Marta Cocco, Carlo Di Mario, Flavia Caniato, Flavio Luciano Ribichini, Daniele Prati, Giuseppe Tarantini, Francesco Cardaioli, Francesco Burzotta, Lazzaro Paraggio, Francesco Bedogni, Luca Arzuffi, Alaide Chieffo, Giulia Ghizzoni, Giedrius Davidavicius, Povilas Budrys, Nicolas Van Mieghem, Joost Daemen, Regine Brinkmann, Hendrik Bante, Maciej Lesiak, Sylwia Iwanczyk, Jerzy Pregowski, Jaroslaw Skowronski, Sergio Madeira, Luis Raposo, Rodrigo Estevez-Loureiro, Antonio Sisinni, Javier Escaned, Adrian Jeronimo, Raul Moreno, Santiago Jimenez-Valero, Pieter Vriesendorp, Tobias Pustjens, Robert Van Geuns, Peter Damman, Tim Van de Hoef, Pim Van der Harst, Mamas A. Mamas, Simon Duckett, Ghada Mikhail, Carla Lucarelli, Colin Berry, Raffaele De Caterina
Journal of cardiovascular medicine, 2025, vol. 26, p.731-740
Combining Surgical and Percutaneous Revascularization for Multivessel Coronary Artery Disease Samuel Heuts, Pim van der Harst, Erika Nodin, Joakim Grant Frederiksen, Patrique Segers, Fabrizio Rosati, Johan Bennett, Arpad Lux, Steven Jacobs, Monica Gianoli, Janus C Jakobsen, Christian Lildal Carranza, Wouter Oosterlinck
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2025, vol. 67
Non-Invasive Remote Monitoring in Heart Failure Camila S Pizarro, Bas B S Schots, Mark J Schuuring, Pim van der Harst, René van Es, Marish I F J Oerlemans
Current Heart Failure Reports, 2025, vol. 22
Machine Learning–Based CCTA-Guided Intensive Atheroprotective Strategy in a Middle-Aged INOCA Patient With Challenging Arterial Features Alexander Kharlamov, Priscilla McElhinney, Pieter Kitslaar, Nicola Gaibazzi, Marco Guglielmo, Pim van der Harst, Avtandil Babunashvili, Alexei Sozykin, Damini Dey, Gianluca Pontone
JACC: Case Reports, 2025, vol. 30, p.105907
Predicting acute coronary events after breast cancer radiotherapy D S Spoor, N B Boekel, F E V Leeuwen, N Russell, S Jacob, S E Combs, M Mayinger, K Borm, R Vliegenthart, P van der Harst, G Sikkema, V A B van den Bogaard, N M Sijtsema, J H Maduro, E Schuit, J A Langendijk, A P G Crijns
European Journal of Cancer, 2025, vol. 231

Fellowships & Awards

Awards

2015

Winner of Humanimal – One Health Innovation Challenge 2015 with the Durrer Center (of which I was Chief Scientific Officer). Price for “Best Professional Idea Flevoland” for our Open One Health Biobank proposal (€ 50,000.--)

2013Scientific Excellence Award from the Board of the UMCG (€ 100,000.--)
2010 Excellence Award from the Netherlands Foundation for Cardiovascular Excellence for Scientific, Clinical and Presenting Excellence (€ 50,000.--)

Fellowships

2012NWO Clinical Fellowship (90.700.441); Systems and functional genomics strategies to identify novel vulnerability genes for heart failure. €160,000.--
2007VENI Fellowship (916.76.170) of the Innovational Research Incentives Scheme of the Netherlands Organization for Scientific Research (NWO); Telomere length in cardiovascular disease; differential expression and prognostic value (€ 248,000.--)
2008ICIN Fellowship (€ 45,000.--) of the Interuniversity Cardiology Institute of the Netherlands

         

 

External positions

Editor-in-Chief - editor - bohn stafleu van loghum

Lid van de Raad van Toezicht - vele raakvlakken - Netherlands Heart Institute

begeleiden promovendi met afronden van hun promotie, eerste promotor - soortgelijk - Universitair Medisch Centrum Groningen

National member of Scientific Advisory Board LifeLines Cohort Study - ja, inhoudelijk advies - LifeLines B.V.

Nucleus member of the center for circulatory health at the UMC Utrecht - ja - UMC Utrecht

begeleiden promovendi met afronden van hun promotie, eerste promotor - soortgelijk - Universitair Medisch Centrum Groningen

National member of Scientific Advisory Board LifeLines Cohort Study - ja, inhoudelijk advies - LifeLines B.V.

Nucleus member of the center for circulatory health at the UMC Utrecht - ja - UMC Utrecht