Profile photo Pim van der Harst

Pim van der Harst

Full Professor

Strategic program(s):

Biography

I am an interventional cardiologist and scientist and head of the department of cardiology of the University Medical Center Utrecht. My clinical work includes the percutaneous treatment of obstructive coronary artery disease, including acute myocardial infarction. My translational research focusses on the analysis of big and complex data (e.g. genetic, ehr, imaging), including the use of machine learning and cloud computing, to improve our understanding and the early detection of coronary artery disease and heart failure. To this end we use large population based cohorts, including the Dutch PREVEND and LifeLine cohorts and the UK Biobank. Data on my "omics" research can be found our my website: www.cardiomics.net  In my clinical translational research I am also working on advanced image analysis, device interventions, machine learning, deep learning, and e/m Health to further improve and personalize care for our patients. Currently ongoing diagnostic imaging studies in include the REPLACE-IT (replacement of invasive coronary angiography) and the EARLY-SYNERGY (early detection of obstructive coronary artery disease; www.early-synergy.nl) studies. Currently interventional studies include the GIPS-IV, AXES and MRI-MC studies. Many of my projects based on collaborations with the most influential and creative individuals and research groups in the world.

Research groups

Inherited heart disease (cardiogenetics)

Research aim

We aim to enhance patient and family lives impacted by inherited cardiomyopathies. Our efforts target gene and variant identification, disease mechanisms, factors influencing disease outcomes, therapy optimization, and exploration of novel therapies.

Go to group

Recent publications

Ablation of Ventricular and Atrial Arrhythmias in the Era of Cardiac Magnetic Resonance Pietro Costantini, Francesca Coraducci, Giulia De Zan, Damiano Fedele, Eleonora Ostillio, Riccardo Bertozzi, Federico Donato, Giuseppe Muscogiuri, Anna Giulia Pavon, Luca Bergamaschi, Carmine Pizzi, Astrid Hendriks, Anneline S J M Te Riele, Dominika Suchá, Sophie Rier, Pim van der Harst, Birgitta Velthuis, Ivo van der Bilt, Anna Colarieti, Alessandro Carriero, Marco Guglielmo
Echocardiography, 2025, vol. 42
Model-Based Cost-Utility Analysis of Combined Low-Dose Computed Tomography Screening for Lung Cancer, Chronic Obstructive Pulmonary Disease, and Cardiovascular Disease Carina M. Behr, Maarten J. IJzerman, Michelle M.A. Kip, Harry J.M. Groen, Marjolein A. Heuvelmans, Maarten van den Berge, Pim van der Harst, Marleen Vonder, Rozemarijn Vliegenthart, Hendrik Koffijberg
JTO clinical and research reports, 2025, vol. 6
Deep learning for electrocardiogram interpretation Bas B S Schots, Camila S Pizarro, Bauke K O Arends, Marish I F J Oerlemans, Dino Ahmetagić, Pim van der Harst, René van Es
European Journal of Clinical Investigation, 2025, vol. 55
Meta-analysis of genome-wide associations and polygenic risk prediction for atrial fibrillation in more than 180,000 cases Carolina Roselli, Ida Surakka, Morten S Olesen, Gardar Sveinbjornsson, Nicholas A Marston, Seung Hoan Choi, Hilma Holm, Mark Chaffin, Daniel Gudbjartsson, Matthew C Hill, Hildur Aegisdottir, Christine M Albert, Alvaro Alonso, Christopher D Anderson, Dan E Arking, David O Arnar, John Barnard, Emelia J Benjamin, Eugene Braunwald, Ben Brumpton, Archie Campbell, Nathalie Chami, Daniel I Chasman, Kelly Cho, Eue-Keun Choi, Ingrid E Christophersen, Mina K Chung, David Conen, Harry J Crijns, Michael J Cutler, Tomasz Czuba, Scott M Damrauer, Martin Dichgans, Marcus Dörr, Elton Dudink, ThuyVy Duong, Christian Erikstrup, Tõnu Esko, Diane Fatkin, Jessica D Faul, Manuel Ferreira, Daniel F Freitag, Santhi K Ganesh, J Michael Gaziano, Bastiaan Geelhoed, Jonas Ghouse, Christian Gieger, Franco Giulianini, Sarah E Graham, Pim van der Harst,
Nature genetics, 2025, vol. 57, p.539-547
Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk Seung Hoan Choi, Sean J Jurgens, Ling Xiao, Matthew C Hill, Christopher M Haggerty, Garðar Sveinbjörnsson, Valerie N Morrill, Nicholas A Marston, Lu-Chen Weng, James P Pirruccello, David O Arnar, Daniel Fannar Gudbjartsson, Helene Mantineo, Aenne S von Falkenhausen, Andrea Natale, Arnljot Tveit, Bastiaan Geelhoed, Carolina Roselli, David R Van Wagoner, Dawood Darbar, Doreen Haase, Elsayed Z Soliman, Giovanni E Davogustto, Goo Jun, Hugh Calkins, Jeffrey L Anderson, Jennifer A Brody, Jennifer L Halford, John Barnard, John E Hokanson, Jonathan D Smith, Joshua C Bis, Kendra Young, Linda S B Johnson, Lorenz Risch, Lorne J Gula, Lydia Coulter Kwee, Mark D Chaffin, Michael Kühne, Michael Preuss, Namrata Gupta, Navid A Nafissi, Nicholas L Smith, Peter M Nilsson, Pim van der Harst, Quinn S Wells, Renae L Judy, Renate B Schnabel, Renee Johnson, Roelof A J Smit,
Nature genetics, 2025, vol. 57, p.548-562
Scientific research in primary health care Moniek Koopman, Jorn Reijnders, Bastiaan Kietselaer, Pim van der Harst, Rykel van Bruggen, Geert-Jan Dinant, Rozemarijn Vliegenthart, Robert Willemsen
Primary health care research & development, 2025, vol. 26

Fellowships & Awards

Awards

2015

Winner of Humanimal – One Health Innovation Challenge 2015 with the Durrer Center (of which I was Chief Scientific Officer). Price for “Best Professional Idea Flevoland” for our Open One Health Biobank proposal (€ 50,000.--)

2013Scientific Excellence Award from the Board of the UMCG (€ 100,000.--)
2010 Excellence Award from the Netherlands Foundation for Cardiovascular Excellence for Scientific, Clinical and Presenting Excellence (€ 50,000.--)

Fellowships

2012NWO Clinical Fellowship (90.700.441); Systems and functional genomics strategies to identify novel vulnerability genes for heart failure. €160,000.--
2007VENI Fellowship (916.76.170) of the Innovational Research Incentives Scheme of the Netherlands Organization for Scientific Research (NWO); Telomere length in cardiovascular disease; differential expression and prognostic value (€ 248,000.--)
2008ICIN Fellowship (€ 45,000.--) of the Interuniversity Cardiology Institute of the Netherlands

         

 

External positions

Editor-in-Chief - editor - bohn stafleu van loghum

Lid van de Raad van Toezicht - vele raakvlakken - Netherlands Heart Institute

begeleiden promovendi met afronden van hun promotie, eerste promotor - soortgelijk - Universitair Medisch Centrum Groningen

National member of Scientific Advisory Board LifeLines Cohort Study - ja, inhoudelijk advies - LifeLines B.V.

Nucleus member of the center for circulatory health at the UMC Utrecht - ja - UMC Utrecht

begeleiden promovendi met afronden van hun promotie, eerste promotor - soortgelijk - Universitair Medisch Centrum Groningen

National member of Scientific Advisory Board LifeLines Cohort Study - ja, inhoudelijk advies - LifeLines B.V.

Nucleus member of the center for circulatory health at the UMC Utrecht - ja - UMC Utrecht