Pieter Vader

Associate Professor

Strategic program(s):

Biography

Pieter Vader graduated in Chemistry (B.Sc., 2005) and Drug Innovation (M.Sc., 2007) from the University of Utrecht. He earned his PhD degree in 2012 from the University of Utrecht on the subject of targeted delivery of siRNA to inhibit tumor angiogenesis.

From 2012 to 2014, Pieter was employed as a (senior) postdoctoral fellow at the University of Oxford, UK, in the lab of Prof. Matthew Wood, supported by a NWO Rubicon fellowship. The research topic was development of small RNA-loaded extracellular vesicles for targeted delivery.

In 2014 he moved back to The Netherlands to continue his work at the University Medical Center Utrecht. Currently, he is Associate Professor at CDL Research and at the Department of Experimental Cardiology. His main research interests are in the field of therapeutic applications of extracellular vesicles, including unraveling the mechanisms underlying extracellular vesicle-mediated cargo transfer. His research has been supported by a NWO Veni Grant (2014), ERC Starting Grant (2019), Dutch Heart Foundation Dekker Senior Scientist Grant (2019), NWO Vidi Grant (2020) and ERC Consolidator Grant (2023). In 2021, Pieter was awarded the Prix Galien Research Award for his work on drug delivery.

Strategic program(s):

Contact

pvader2@umcutrecht.nl

Pure profile

Research groups

Nanomedicine lab

Research aim

We develop synthetic and biological nanomedicine for targeted drug delivery

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Recent publications

All publications

Cardiac delivery of modified mRNA using lipid nanoparticles M C I Labonia, M Estapé Senti, P H van der Kraak, M A D Brans, I Dokter, T J Streef, A M Smits, A K Deshantri, S C A de Jager, R M Schiffelers, J P G Sluijter, P Vader
Journal of controlled release : official journal of the Controlled Release Society, 2024, vol. 369, p.734-745

Extracellular vesicle-mediated delivery of CRISPR/Cas9 ribonucleoprotein complex targeting proprotein convertase subtilisin-kexin type 9 (Pcsk9) in primary mouse hepatocytes Nazma F Ilahibaks, Thomas A Kluiver, Olivier G de Jong, Saskia C A de Jager, Raymond M Schiffelers, Pieter Vader, Weng Chuan Peng, Zhiyong Lei, Joost P G Sluijter
Journal of Extracellular Vesicles, 2024, vol. 13

Scalable purification of extracellular vesicles with high yield and purity using multimodal flowthrough chromatography Scott E. Bonner, Simonides I. van de Wakker, William Phillips, Eduard Willms, Joost P.G. Sluijter, Andrew F. Hill, Matthew J.A. Wood, Pieter Vader
Journal of Extracellular Biology, 2024, vol. 3

Hypoxia and TNF-alpha modulate extracellular vesicle release from human induced pluripotent stem cell-derived cardiomyocytes Margarida Viola, Maarten P. Bebelman, Renee G.C. Maas, Willemijn S. de Voogt, Frederik J. Verweij, Cor S. Seinen, Saskia C.A. de Jager, Pieter Vader, Dirk Michiel Pegtel, Joost Petrus Gerardus Sluijter
Journal of Extracellular Vesicles, 2024, vol. 13

Size matters: Functional differences of small extracellular vesicle subpopulations in cardiac repair responses Simon van de Wakker, Julia Bauzá-Martinez, Carla Rios Arceo, Herak Manjikian, Christian J.B. Snijders Blok, Marieke Roefs, Renee G Maas, Eduard Willms, Matti F. Pronker, Olivier de Jong, Wei Wu, André Görgens, Samir E L Andaloussi, Joost Sluijter, Pieter Vader
Journal of Extracellular Vesicles, 2024, vol. 13

Minimal information for studies of extracellular vesicles (MISEV2023) Joshua A. Welsh, Deborah C.I. Goberdhan, Lorraine O’Driscoll, Edit I. Buzas, Cherie Blenkiron, Benedetta Bussolati, Houjian Cai, Dolores Di Vizio, Tom A.P. Driedonks, Uta Erdbrügger, Juan M. Falcon-Perez, Qing Ling Fu, Andrew F. Hill, Metka Lenassi, Sai Kiang Lim, G. Mahoney M˜y, Sujata Mohanty, Andreas Möller, Rienk Nieuwland, Takahiro Ochiya, Susmita Sahoo, Ana C. Torrecilhas, Lei Zheng, Andries Zijlstra, Sarah Abuelreich, Reem Bagabas, Paolo Bergese, Esther M. Bridges, Marco Brucale, Dylan Burger, Randy P. Carney, Emanuele Cocucci, Rossella Crescitelli, Edveena Hanser, Adrian L. Harris, Norman J. Haughey, An Hendrix, Alexander R. Ivanov, Tijana Jovanovic-Talisman, Nicole A. Kruh-Garcia, Bas W.M. van Balkom, Federica Collino, Olivier G. de Jong, Sander A.A. Kooijmans, Magdalena J. Lorenowicz, Kenny Man, Marieke T. Roefs, Raymond M. Schiffelers, Joost P.G. Sluijter, Pieter Vader,
Journal of Extracellular Vesicles, 2024, vol. 13

Fellowships & Awards

2019: ERC Starting Grant

2014: VENI

2011: Rubicon grant

External positions

Associate Editor - Editoriale werkzaamheden - Elsevier BV

Lid van de wetenschappelijke adviesraad - Het bedrijf ontwikkelt membraanblaasjes voor therapeutische toepassingen. - EVOX THERAPEUTICS LIMITED