Paul van Diest

Full Professor

Strategic program(s):

Biography

Paul J van Diest has been a dedicated cancer researcher since the start of his career, obtaining numerous grants a.o. from the NIH and the Dutch Cancer Society. He studied Medicine, did his PhD and pathology residency at the VU University medical center (VUMC) in Amsterdam. After obtaining his Board certification in Pathology in 1996, he became Consultant Pathologist at the Department of Pathology of the VUMC. In 1999 he was appointed Associate Professor and in 2001 to full Professor. In 2003 he moved to Utrecht to become Head of the Department of Pathology at the University Medical Center Utrecht (UMCU) where he is currently still working. He is Adjunct Professor of Oncology at the Sidney Kimmel Oncology Center at Johns Hopkins, Baltimore, USA. He serves on the editorial board of >20 international journals. He has been active in the board as secretary and president of several international societies. He has published >900 papers in peer reviewed journals, personally supervised 90 PhD theses, and has an H-index of 99. The main theme of his research is finding ways for prevention, optimized diagnosis and cure of breast cancer, both the male and female forms. He is also active in the field of implementing digital pathology and AI.

Strategic program(s):

Contact

pdiest@umcutrecht.nl

Pure profile

Research groups

Translational breast cancer research group

Research aim

We aim to optimize early diagnosis and treatment of breast cancer, especially rare breast cancers like pregnancy associated, male & lobular breast cancer. We refine tissue diagnostics with molecular techniques/AI, and apply nipple fluid/blood tests.

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AI in pathology

Research aim

To develop, validate, and implement AI in digital pathology practice

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Recent publications

All publications

Deep learning on CT scans to predict checkpoint inhibitor treatment outcomes in advanced melanoma Laurens S Ter Maat, Rob A J De Mooij, Isabella A J Van Duin, Joost J C Verhoeff, Sjoerd G Elias, Tim Leiner, Wouter A C van Amsterdam, Max F Troenokarso, Eran R A N Arntz, Franchette W P J Van den Berkmortel, Marye J Boers-Sonderen, Martijn F Boomsma, Fons J M Van den Eertwegh, Jan Willem de Groot, Geke A P Hospers, Djura Piersma, Art Vreugdenhil, Hans M Westgeest, Ellen Kapiteijn, Ardine A De Wit, Willeke A M Blokx, Paul J Van Diest, Pim A De Jong, Josien P W Pluim, Karijn P M Suijkerbuijk, Mitko Veta
Scientific Reports, 2024, vol. 14

Multimodal genome-wide survey of progressing and non-progressing breast ductal carcinoma in-situ Marija Debeljak, Soonweng Cho, Bradley M. Downs, Michael Considine, Brittany Avin-McKelvey, Yongchun Wang, Phillip N. Perez, William E. Grizzle, Katherine A. Hoadley, Charles F. Lynch, Brenda Y. Hernandez, Paul J. van Diest, Wendy Cozen, Ann S. Hamilton, Debra Hawes, Edward Gabrielson, Ashley Cimino-Mathews, Liliana D. Florea, Leslie Cope, Christopher B. Umbricht
Breast Cancer Research, 2024, vol. 26

RNA helicase DDX3 regulates RAD51 localization and DNA damage repair in Ewing sarcoma Matthew E. Randolph, Marwa Afifi, Aparna Gorthi, Rachel Weil, Breelyn A. Wilky, Joshua Weinreb, Paul Ciero, Natalie ter Hoeve, Paul J. van Diest, Venu Raman, Alexander J.R. Bishop, David M. Loeb
iScience, 2024, vol. 27

Artificial Intelligence-Based Sentinel Lymph Node Metastasis Detection in Cervical Cancer † Ilse G.T. Baeten, Jacob P. Hoogendam, Nikolas Stathonikos, Cornelis G. Gerestein, Geertruida N. Jonges, Paul J. van Diest, Ronald P. Zweemer
Cancers, 2024, vol. 16

Breast cancer survival prediction using an automated mitosis detection pipeline Nikolas Stathonikos, Marc Aubreville, Sjoerd de Vries, Frauke Wilm, Christof A Bertram, Mitko Veta, Paul J van Diest
The journal of pathology. Clinical research, 2024, vol. 10

Disease extent according to baseline [18F]fluorodeoxyglucose PET/CT and molecular subtype Florien J G van Amstel, Cornelis M de Mooij, Janine M Simons, Cristina Mitea, Paul J van Diest, Patty J Nelemans, Carmen C van der Pol, Ernest J T Luiten, Linetta B Koppert, Marjolein L Smidt, Thiemo J A van Nijnatten,
The British journal of surgery, 2024, vol. 111

Fellowships & Awards

Dutch Cancer Society (KWF)

Health Care Efficiency Research Programme of The Netherlands Organization for Health Research and Development (ZonMw)

External positions

Board of Advisors - Adviseren - ESDIP

Advisory Board - Jaarlijkse meeting duur 1 dag bijwonen - Visiopharm

Advisor - AI ontwikkeling en research wordt gedaan op afdeling - PAIGE

Member of the Digital Pathology advisory board of Paige - Op basis van expertise - Paige

Contractresearch - Vanuit de expertise van mijn huidige functie - Samantree

Visiting Professor. lesgeven, opleiding AIOS uit Siena voor stage althier - Op basis expertise - University of Siena, Italy

Zie bijlage - Alles op basis van expertise in mijn functie - Varia alle inkomsten t.g.v. UMC Utrecht zie bijlage

Member of the Digital Pathology advisory board of Philips - Vanuit mijn expertise - Philips

Wetenschappelijk - Vanuit mijn expertise - Sidney Kimmel Oncology Center at Johns Hopkins