Researchers Patricia Olofsen-Dieleman

Patricia Olofsen-Dieleman

Researcher/Postdoc

Strategic program(s):

Biography

Dr Patricia Olofsen is a postdoc in the Center for Translational Immunology (CTI) at the University Medical Center Utrecht, the Netherlands. She obtained her PhD in 2021 at the Erasmus University on the molecular and cellular defects driving the leukemic progression of severe congenital neutropenia. Intrigued by neutrophils, cytokines and cancer, she joined the Leusen lab in 2021 to study the role of cytokines in attracting and activating neutrophils to kill tumor cells using IgA monoclonal antibodies.

Strategic program(s):

Contact

p.a.olofsen@umcutrecht.nl

Pure profile

Recent publications

All publications

Enhancing neutrophil cytotoxicity of a panel of clinical EGFR antibodies by Fc engineering to IgA3.0 Chilam Chan, J. H.Marco Jansen, Ilona S.T. Hendriks, Ida C. van der Peet, Meggy E.L. Verdonschot, Elsemieke M. Passchier, Maria Tsioumpekou, Maaike Nederend, Sharon A. Klomp, Thomas Valerius, Matthias Peipp, Jeanette H.W. Leusen, Patricia A. Olofsen
MOLECULAR CANCER THERAPEUTICS, 2024, vol. 23, p.1317-1331

Characterization of human Fc alpha receptor transgenic mice Marjolein C. Stip, J. H.Marco Jansen, Maaike Nederend, Maria Tsioumpekou, Mitchell Evers, Patricia A. Olofsen, Friederike Meyer-Wentrup, Jeanette H.W. Leusen
Cancer Immunology, Immunotherapy, 2023, vol. 72, p.3063-3077

The Role of Cytokines in Neutrophil Development, Tissue Homing, Function and Plasticity in Health and Disease Maria Tsioumpekou, Daniëlle Krijgsman, Jeanette H W Leusen, Patricia A Olofsen
Cells, 2023, vol. 12

Effective, Long-Term, Neutrophil Depletion Using a Murinized Anti-Ly-6G 1A8 Antibody Patricia A. Olofsen, Marjolein C. Stip, J. H.Marco Jansen, Chilam Chan, Maaike Nederend, Ralph G. Tieland, Maria Tsioumpekou, Jeanette H.W. Leusen
Cells, 2022, vol. 11

PML-controlled responses in severe congenital neutropenia with ELANE-misfolding mutations Patricia A. Olofsen, Dennis A. Bosch, Onno Roovers, Paulina M.H. van Strien, Hans W.J. de Looper, Remco M. Hoogenboezem, Sander Barnhoorn, Pier G. Mastroberardino, Mehrnaz Ghazvini, Vincent H.J. van der Velden, Eric M.J. Bindels, Emma M. de Pater, Ivo P. Touw
Blood Advances, 2021, vol. 5, p.775-786

RUNX1 Mutations in the Leukemic Progression of Severe Congenital Neutropenia Patricia A. Olofsen, Ivo P. Touw
Molecules and Cells, 2020, vol. 43, p.139-144