Profile photo Gerard Pasterkamp

Gerard Pasterkamp

Full Professor

Strategic program(s):

Biography

Gerard Pasterkamp, MD, is professor Experimental Cardiology and quarter maker of the Circulatory Health Research Center, UMC Utrecht. His research interests are in the field of cardiovascular biology and more specifically innovation in biomarkers. His research interests are in the field of cardiovascular biology and innovation in biomarkers and drug targets. The research group houses the largest atherosclerotic plaque biobank worldwide: Athero Express including >4000 patients. This biobank has generated new insights into determinants of plaque destabilisation. The laboratory also invests in the excavation of genetic determinants of atherosclerotic plaque characteristics. He coordinates national and EU based consortia with the aim to unravel biomarkers and mechanisms of atherosclerotic disease. His translational profile is noted in the private public consortia he is involved in. He is supervising three public private grants that have been rewarded with the aim to develop novel biomarkers and imaging technology to detect cardiac ischemia and endothelial dysfunction. In 2018 he obtained a LeDucq grant together with Prof G Owens (Virginia University) on the role of smooth muscle cell plasticity in the atherosclerotic plaque. 

Recent publications

Atherosclerotic Plaque Epigenetic Age Acceleration Predicts a Poor Prognosis and Is Associated With Endothelial-to-Mesenchymal Transition in Humans Ernest Diez Benavente, Robin J G Hartman, Tim R Sakkers, Marian Wesseling, Yannicke Sloots, Lotte Slenders, Arjan Boltjes, Barend M Mol, Gert J de Borst, Dominique P V de Kleijn, Koen H M Prange, Menno P J de Winther, Johan Kuiper, Mete Civelek, Sander W van der Laan, Steve Horvath, Charlotte Onland-Moret, Michal Mokry, Gerard Pasterkamp, Hester M den Ruijter
Arteriosclerosis, Thrombosis, and Vascular Biology, 2024, vol. 44, p.1419-1431
A critical appreciation of pathway analysis in atherosclerotic disease. Cellular phenotypic plasticity as an illustrative example M Wesseling, E Diez-Benavente, M Mokry, H M den Ruijter, G Pasterkamp
Vascular Pharmacology, 2024, vol. 154, p.1-5
IL-1β Inhibition Partially Negates the Beneficial Effects of Diet-Induced Atherosclerosis Regression in Mice Santosh Karnewar, Vaishnavi Karnewar, Rebecca A. Deaton, Laura S. Shankman, Ernest D. Benavente, Corey M. Williams, Xenia Bradley, Gabriel F. Alencar, Gamze B. Bulut, Sara Kirmani, Richard A. Baylis, Eli R. Zunder, Hester M. Den Ruijter, Gerard Pasterkamp, Gary K. Owens
Arteriosclerosis, Thrombosis, and Vascular Biology, 2024, vol. 44, p.1379-1392
Single-Cell Gene-Regulatory Networks of Advanced Symptomatic Atherosclerosis Giuseppe Mocci, Katyayani Sukhavasi, Tiit Örd, Sean Bankier, Prosanta Singha, Uma Thanigai Arasu, Olayinka Oluwasegun Agbabiaje, Petri Mäkinen, Lijiang Ma, Chani J. Hodonsky, Redouane Aherrahrou, Lars Muhl, Jianping Liu, Sonja Gustafsson, Byambajav Byandelger, Ying Wang, Simon Koplev, Urban Lendahl, Gary K. Owens, Nicholas J. Leeper, Gerard Pasterkamp, Michael Vanlandewijck, Tom Michoel, Arno Ruusalepp, Ke Hao, Seppo Ylä-Herttuala, Marika Väli, Heli Järve, Michal Mokry, Mete Civelek, Clint J. Miller, Jason C. Kovacic, Minna U. Kaikkonen, Christer Betsholtz, Johan L.M. Björkegren
Circulation research, 2024, vol. 134, p.1405-1423
Perioperative platelet reactivity over time in patients undergoing vascular surgery A.R.T. Brand Kanters, N. C. Roozendaal, N.M.J. Parr, G. Pasterkamp, R. T. Urbanus, S. J.A. Korporaal, Gert J. de Borst
PLoS ONE, 2024, vol. 19
Identification of a gene network driving the attenuated response to lipopolysaccharide of monocytes from hypertensive coronary artery disease patients Chang Lu, Marjo M P C Donners, Julius B J de Baaij, Han Jin, Jeroen J T Otten, Marco Manca, Anton Jan van Zonneveld, J Wouter Jukema, Adriaan Kraaijeveld, Johan Kuiper, Gerard Pasterkamp, Barend Mees, Judith C Sluimer, Rachel Cavill, Joël M H Karel, Pieter Goossens, Erik A L Biessen
Frontiers in Immunology, 2024, vol. 15

Fellowships & Awards

2006: Het navigatiesysteem van zenuwcellen