Profile photo Gerard Pasterkamp

Gerard Pasterkamp

Full Professor

Strategic program(s):

Biography

Gerard Pasterkamp, MD, is professor Experimental Cardiology and quarter maker of the Circulatory Health Research Center, UMC Utrecht. His research interests are in the field of cardiovascular biology and more specifically innovation in biomarkers. His research interests are in the field of cardiovascular biology and innovation in biomarkers and drug targets. The research group houses the largest atherosclerotic plaque biobank worldwide: Athero Express including >4000 patients. This biobank has generated new insights into determinants of plaque destabilisation. The laboratory also invests in the excavation of genetic determinants of atherosclerotic plaque characteristics. He coordinates national and EU based consortia with the aim to unravel biomarkers and mechanisms of atherosclerotic disease. His translational profile is noted in the private public consortia he is involved in. He is supervising three public private grants that have been rewarded with the aim to develop novel biomarkers and imaging technology to detect cardiac ischemia and endothelial dysfunction. In 2018 he obtained a LeDucq grant together with Prof G Owens (Virginia University) on the role of smooth muscle cell plasticity in the atherosclerotic plaque. 

Recent publications

Computational Modeling Predicts Benefits of Proefferocytic Therapy in Human Atherosclerosis Kai-Uwe Jarr, Kaylin C A Palm, Gerard Pasterkamp, Michal Mokry, Nicholas J Leeper
Circulation, 2025, vol. 152, p.208-211
Genetically determined ancestry associates with morphological and molecular carotid plaque features Nima Fahim, Tim R Sakkers, Joost Hoekstra, Dominique P V de Kleijn, Michal Mokry, Jose Verdezoto Mosquera, Gerard Pasterkamp, Hester M den Ruijter, Clint L Miller, Jessica van Setten, Sander W van der Laan
2025
A Comparative Proteomics Study of Autopsy and Fresh-Frozen Coronary Artery Samples Xiaoke Yin PhD, Alicia Beele MSc, Konstantinos Theofilatos PhD, Ferheen Baig PhD, Maria Hasman PhD, Lukas E Schmidt MSc, Joseph J Boyle PhD, Adam W Turner PhD, Clint L Miller PhD, Gerard Pasterkamp Md, Stefan Stojkovic Md PhD, Johann Wojta PhD, Michael Joner Md, Manuel Mayr Md PhD
Journal of Proteome Research, 2025, vol. 24, p.3154-3159
Proteomic profiling reveals a higher presence of glycolytic enzymes in human atherosclerotic lesions with unfavourable histological characteristics Kaylin C A Palm, Xiaoke Yin, Ferheen Baig, Konstantinos Theofilatos, Sander W van der Laan, Gert J de Borst, Dominique P V de Kleijn, Johann Wojta, Stefan Stojkovic, Manuel Mayr, Hester M den Ruijter, Gerard Pasterkamp, Ernest Diez Benavente, Michal Mokry
Cardiovascular research, 2025, vol. 121, p.1187-1203
Endothelial-to-mesenchymal transition gene signature derived from single-cell transcriptomics of human atherosclerotic tissue associates with stable plaque histological characteristics Lotte Slenders, Marian Wesseling, Siting Wei, Arjan Boltjes, Daniek M C Kapteijn, Petra van de Kraak, Marie A C Depuydt, Koen Prange, Noortje A M van den Dungen, Ernest Diez Benavente, Dominique P V de Kleijn, Gert J de Borst, Menno de Winther, Hester M den Ruijter, Gary K Owens, Gerard Pasterkamp, Michal Mokry
Vascular Pharmacology, 2025, vol. 159
Plaque erosion Gerard Pasterkamp, Hester M den Ruijter, Michal Mokry
European heart journal, 2025, vol. 46, p.2220-2222

External positions

reviewerspanel/commissie Health Holland ronde oktober 2024 - reviewen en met commissie belsuiten over honorering aanvragen - Health Holland

auteur - uitgeven van een boek, maar aantal uren is niet (meer) van toepassing. werk is al gedaan - persoonlijk, geen werkgever

Voorzitter Wetenschappelijke Adviesraad - Voorzitten vergaderingen - Reuma Nederland