Profile photo Gerard Pasterkamp

Gerard Pasterkamp

Full Professor

Strategic program(s):

Biography

Gerard Pasterkamp, MD, is professor Experimental Cardiology and quarter maker of the Circulatory Health Research Center, UMC Utrecht. His research interests are in the field of cardiovascular biology and more specifically innovation in biomarkers. His research interests are in the field of cardiovascular biology and innovation in biomarkers and drug targets. The research group houses the largest atherosclerotic plaque biobank worldwide: Athero Express including >4000 patients. This biobank has generated new insights into determinants of plaque destabilisation. The laboratory also invests in the excavation of genetic determinants of atherosclerotic plaque characteristics. He coordinates national and EU based consortia with the aim to unravel biomarkers and mechanisms of atherosclerotic disease. His translational profile is noted in the private public consortia he is involved in. He is supervising three public private grants that have been rewarded with the aim to develop novel biomarkers and imaging technology to detect cardiac ischemia and endothelial dysfunction. In 2018 he obtained a LeDucq grant together with Prof G Owens (Virginia University) on the role of smooth muscle cell plasticity in the atherosclerotic plaque. 

Recent publications

Zebrafish model for functional screening of flow-responsive genes controlling endothelial cell proliferation George Bowley, Sophie Irving, Imo Hoefer, Robert Wilkinson, Gerard Pasterkamp, Hazem M.S. Darwish, Stephen White, Sheila E. Francis, Tim Chico, Emily Noel, Jovana Serbanovic-Canic, Paul C. Evans
Scientific Reports, 2024, vol. 14
Atherosclerotic Plaque Epigenetic Age Acceleration Predicts a Poor Prognosis and Is Associated With Endothelial-to-Mesenchymal Transition in Humans Ernest Diez Benavente, Robin J G Hartman, Tim R Sakkers, Marian Wesseling, Yannicke Sloots, Lotte Slenders, Arjan Boltjes, Barend M Mol, Gert J de Borst, Dominique P V de Kleijn, Koen H M Prange, Menno P J de Winther, Johan Kuiper, Mete Civelek, Sander W van der Laan, Steve Horvath, Charlotte Onland-Moret, Michal Mokry, Gerard Pasterkamp, Hester M den Ruijter
Arteriosclerosis, Thrombosis, and Vascular Biology, 2024, vol. 44, p.1419-1431
The Effects of FABP4 on Cardiovascular Disease in the Aging Population Ellen M. van der Ark-Vonk, Mike V. Puijk, Gerard Pasterkamp, Sander W. van der Laan
Current atherosclerosis reports, 2024, vol. 26, p.163-175
A critical appreciation of pathway analysis in atherosclerotic disease. Cellular phenotypic plasticity as an illustrative example M Wesseling, E Diez-Benavente, M Mokry, H M den Ruijter, G Pasterkamp
Vascular Pharmacology, 2024, vol. 154, p.1-5
Tobacco smoking is associated with sex- and plaque-type specific upregulation of CRLF1 in atherosclerotic lesions Tian Lan, Kaylin C.A. Palm, Luka Hoeben, Ernest Diez Benavente, R. Noah Perry, Mete Civelek, Dominique P.V. de Kleijn, Hester M. den Ruijter, Gerard Pasterkamp, Michal Mokry
Atherosclerosis, 2024, vol. 397
Human atherosclerotic plaque transcriptomics reveals endothelial beta-2 spectrin as a potential regulator a leaky plaque microvasculature phenotype Timo Rademakers, Marco Manca, Han Jin, Tanguy Orban, Ljubica Matic Perisic, Hubertus J.M. Frissen, Frank Rühle, Petra Hautvast, Jos van Rijssel, Kim van Kuijk, Barend M.E. Mees, Carine J. Peutz-Kootstra, Sylvia Heeneman, Mat J.A.P. Daemen, Gerard Pasterkamp, Monika Stoll, Marc A.M.J. van Zandvoort, Ulf Hedin, Franck Dequiedt, Jaap D. van Buul, Judith C. Sluimer, Erik A.L. Biessen
Angiogenesis, 2024, vol. 27, p.461-474

External positions

reviewerspanel/commissie Health Holland ronde oktober 2024 - reviewen en met commissie belsuiten over honorering aanvragen - Health Holland

auteur - uitgeven van een boek, maar aantal uren is niet (meer) van toepassing. werk is al gedaan - persoonlijk, geen werkgever

Voorzitter Wetenschappelijke Adviesraad - Voorzitten vergaderingen - Reuma Nederland