Onur Basak

Assistant Professor

Strategic program(s):

Contact

obasak@umcutrecht.nl

Pure profile

Research groups

Single cell biology of neural cell identity

Research aim

We strive to discover how the immense cellular diversity of the human brain is generated and maintain. The mechanisms specifying cellular identity help us better understand brain function as well as cognitive dysfunction and malignant growth.

Go to group

Recent publications

All publications

Molecular pathology, developmental changes and synaptic dysfunction in (pre-) symptomatic human C9ORF72-ALS/FTD cerebral organoids Astrid T van der Geest, Channa E Jakobs, Tijana Ljubikj, Christiaan F M Huffels, Marta Cañizares Luna, Renata Vieira de Sá, Youri Adolfs, Marina de Wit, Daan H Rutten, Marthe Kaal, Maria M Zwartkruis, Mireia Carcolé, Ewout J N Groen, Elly M Hol, Onur Basak, Adrian M Isaacs, Henk-Jan Westeneng, Leonard H van den Berg, Jan H Veldink, Domino K Schlegel, R Jeroen Pasterkamp
Acta neuropathologica communications, 2024, vol. 12

ATAXIN-2 intermediate-length polyglutamine expansions elicit ALS-associated metabolic and immune phenotypes Renata Vieira de Sá, Emma Sudria-Lopez, Marta Cañizares Luna, Oliver Harschnitz, Dianne M A van den Heuvel, Sandra Kling, Danielle Vonk, Henk-Jan Westeneng, Henk Karst, Lauri Bloemenkamp, Suzy Varderidou-Minasian, Domino K Schlegel, Mayte Mars, Mark H Broekhoven, Nicky C H van Kronenburg, Youri Adolfs, Vamshidhar R Vangoor, Rianne de Jongh, Tijana Ljubikj, Lianne Peeters, Sabine Seeler, Enric Mocholi, Onur Basak, David Gordon, Fabrizio Giuliani, Tessa Verhoeff, Giel Korsten, Teresa Calafat Pla, Morten T Venø, Jørgen Kjems, Kevin Talbot, Michael A van Es, Jan H Veldink, Leonard H van den Berg, Pavol Zelina, R Jeroen Pasterkamp
Nature Communications, 2024, vol. 15

GFAP-isoforms in the nervous system Alexandra J E M de Reus, Onur Basak, Werner Dykstra, Jessy V van Asperen, Emma J van Bodegraven, Elly M Hol
Current Opinion in Cell Biology, 2024, vol. 87

Humanized brain organoids-on-chip integrated with sensors for screening neuronal activity and neurotoxicity Pelin Saglam-Metiner, Ender Yildirim, Can Dincer, Onur Basak, Ozlem Yesil-Celiktas
Mikrochimica acta, 2024, vol. 191

Single-cell profiling of human subventricular zone progenitors identifies SFRP1 as a target to re-activate progenitors Vanessa Donega, Astrid T. van der Geest, Jacqueline A. Sluijs, Roland E. van Dijk, Chi Chiu Wang, Onur Basak, R. Jeroen Pasterkamp, Elly M. Hol
Nature Communications, 2022, vol. 13, p.1-12

Molecular profile and response to energy deficit of leptin-receptor neurons in the lateral hypothalamus N Kakava-Georgiadou, V Drkelic, K M Garner, M C M Luijendijk, O Basak, R A H Adan
Scientific Reports, 2022, vol. 12