Onur Basak

Assistant Professor

Strategic program(s):

Contact

obasak@umcutrecht.nl

Pure profile

Research groups

Single cell biology of neural cell identity

Research aim

We strive to discover how the immense cellular diversity of the human brain is generated and maintain. The mechanisms specifying cellular identity help us better understand brain function as well as cognitive dysfunction and malignant growth.

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Recent publications

All publications

Molecular pathology, developmental changes and synaptic dysfunction in (pre-) symptomatic human C9ORF72-ALS/FTD cerebral organoids Astrid T van der Geest, Channa E Jakobs, Tijana Ljubikj, Christiaan F M Huffels, Marta Cañizares Luna, Renata Vieira de Sá, Youri Adolfs, Marina de Wit, Daan H Rutten, Marthe Kaal, Maria M Zwartkruis, Mireia Carcolé, Ewout J N Groen, Elly M Hol, Onur Basak, Adrian M Isaacs, Henk-Jan... Show all

ATAXIN-2 intermediate-length polyglutamine expansions elicit ALS-associated metabolic and immune phenotypes Renata Vieira de Sá, Emma Sudria-Lopez, Marta Cañizares Luna, Oliver Harschnitz, Dianne M A van den Heuvel, Sandra Kling, Danielle Vonk, Henk-Jan Westeneng, Henk Karst, Lauri Bloemenkamp, Suzy Varderidou-Minasian, Domino K Schlegel, Mayte Mars, Mark H Broekhoven, Nicky C H van Kronenburg, Youri Adolfs, Vamshidhar R Vangoor, Rianne de... Show all

GFAP-isoforms in the nervous system Alexandra J E M de Reus, Onur Basak, Werner Dykstra, Jessy V van Asperen, Emma J van Bodegraven, Elly M Hol
Current Opinion in Cell Biology, 2024, vol. 87

Humanized brain organoids-on-chip integrated with sensors for screening neuronal activity and neurotoxicity Pelin Saglam-Metiner, Ender Yildirim, Can Dincer, Onur Basak, Ozlem Yesil-Celiktas
Mikrochimica acta, 2024, vol. 191

Single-cell profiling of human subventricular zone progenitors identifies SFRP1 as a target to re-activate progenitors Vanessa Donega, Astrid T. van der Geest, Jacqueline A. Sluijs, Roland E. van Dijk, Chi Chiu Wang, Onur Basak, R. Jeroen Pasterkamp, Elly M. Hol
Nature Communications, 2022, vol. 13, p.1-12

Molecular signatures and cellular diversity during mouse habenula development Lieke L. van de Haar, Danai Riga, Juliska E. Boer, Oxana Garritsen, Youri Adolfs, Thomas E. Sieburgh, Roland E. van Dijk, Kyoko Watanabe, Nicky C.H. van Kronenburg, Mark H. Broekhoven, Danielle Posthuma, Frank J. Meye, Onur Basak, R. Jeroen Pasterkamp
Cell Reports, 2022, vol. 40, p.1-32