Profile photo Monique Nijhuis

Monique Nijhuis

Associate Professor

Biography

Monique Nijhuis studied Molecular Biology and obtained her PhD in 1999 at the University of Utrecht on the investigation of the impact of antiretroviral therapy on HIV fitness. Following postdoctoral research training in respiratory viruses she initiated her own research line and became an associate Professor of Virology at the University Medical Center Utrecht in The Netherlands. She is heading the Translational Virology group which performs research at the interface between fundamental and clinical virology. Her research is centered on (I) Viral entry, transmission and pathogenesis (II) Mechanisms of antiviral resistance and viral evolution and (III) Viral-reservoirs and eradication. Monique Nijhuis was granted by the Netherlands Organization for Scientific Research (NWO) with the VIDI and ASPASIA award. She is a member of the IAS HIV Cure International Scientific Working Group and the scientific advisory board of the Dutch Aidsfonds and associate editor of Retrovirology. She has published over 100 papers in peer-reviewed journals and has guided technicians, PhD student, and Postdoctoral Fellows. 

She is teaching Virology in the Bachelor Biomedical Sciences and several Master and PhD programs. She has mentored numerous Bachelor and Graduate students. She is heading the Biological Safety Committee supervising several Biosafety Level III laboratories.

Research groups

Translational virology

Research aim

By integrating insights from clinical and fundamental research on drug resistance, viral persistence, and evolution, we aim to improve antiviral treatment and viral eradication strategies globally

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Recent publications

Sustained HIV remission after allogeneic hematopoietic stem cell transplantation with wild-type CCR5 donor cells Asier Sáez-Cirión, Anne Claire Mamez, Véronique Avettand-Fenoel, Mitja Nabergoj, Caroline Passaes, Paul Thoueille, Laurent Decosterd, Maxime Hentzien, Federico Perdomo-Celis, Maria Salgado, Monique Nijhuis, Adeline Mélard, Elise Gardiennet, Valérie Lorin, Valérie Monceaux, Anaïs Chapel, Maël Gourvès, Marine Lechartier, Hugo Mouquet, Annemarie Wensing, Javier Martinez-Picado, Sabine Yerly, Mathieu Rougemont, Alexandra Calmy
Nature medicine, 2024, vol. 30, p.3544-3554
Characterization of HIV variants from paired Cerebrospinal fluid and Plasma samples in primary microglia and CD4+ T-cells Stephanie B.H. Gumbs, Arjen J. Stam, Tania Mudrikova, Pauline J. Schipper, Andy I.M. Hoepelman, Petra M. van Ham, Anne L. Borst, LMarije Hofstra, Lavina Gharu, Stephanie van Wyk, Eduan Wilkinson, Lot D. de Witte, Annemarie M.J. Wensing, Monique Nijhuis
Journal of Neurovirology, 2024, vol. 30, p.380-392
Defective proviruses significantly impact viral transcription and immune activation in men and women with HIV-1 subtype C in rural South Africa Ninée V.E.J. Buchholtz, Lucas E. Hermans, Chijioke N. Umunnakwe, Marieke M. Nühn, Regina Voss, Emma Need, Neeltje A. Kootstra, Irma Maurer, Dorien C.M. de Jong, Jori Symons, Hugo A. Tempelman, Annemarie M.J. Wensing, Monique Nijhuis
Frontiers in Immunology, 2024, vol. 15
Dynamics of virological and immunological markers of HIV persistence after allogeneic haematopoietic stem-cell transplantation in the IciStem cohort Maria Salgado, Cristina Gálvez, Monique Nijhuis, Mi Kwon, E Fabian Cardozo-Ojeda, Jon Badiola, Matthew J Gorman, Laura E P Huyveneers, Victor Urrea, Alessandra Bandera, Björn-Erik Ole Jensen, Linos Vandekerckhove, Manuel Jurado, Kavita Raj, Julian Schulze Zur Wiesch, Rebeca Bailén, Johanna M Eberhard, Mitja Nabergoj, Gero Hütter, Raquel Saldaña-Moreno, Sharon Oldford, Lisa Barrett, Maria Luisa Montes Ramirez, Salisu Garba, Ravi Kumar Gupta, Boris Revollo, Christelle Ferra-Coll, Jurgen Kuball, Galit Alter, Asier Sáez-Cirión, Jose Luis Diez-Martin, Elizabeth R Duke, Joshua T Schiffer, Annemarie Wensing, Javier Martinez-Picado,
The lancet. HIV, 2024, vol. 11, p.e389-e405
Periodontal inflammation as a potential driver of HIV low level viremia Arjen J. Stam, Hester Groenewegen, Arjan Vissink, Annemarie M.J. Wensing, Monique Nijhuis, Wouter F.W. Bierman
PLoS ONE, 2024, vol. 19
Development of a highly sensitive and specific intact proviral DNA assay for HIV-1 subtype B and C N. V.E.J. Buchholtz, M. M. Nühn, T. C.M. de Jong, T. A.T. Stienstra, K. Reddy, T. Ndung’u, Z. M. Ndhlovu, K. Fisher, S. Palmer, A. M.J. Wensing, J. Symons, M. Nijhuis
Virology Journal, 2024, vol. 21