Full Professor
Strategic program(s):
Biography
Biography
Nicolette Notermans obtained her PhD degree on the clinical features and pathogenesis of Chronic Idiopathic Axonal Polyneuropathy (CIAP) and Polyneuropathy associated with Monoclonal Gammopathy of undetermined significance (MGUS) in Utrecht (1994). After her PhD she obtained several grants (NWO, Prinses Beatrix foundation) to study the etiology of CIAP, polyneuropathy associated with MGUS and other immune-mediated neuropathies. She has initiated several studies of large, national cohorts of patients with CIAP and MGUS, in close collaboration with haematologists throughout the country.
She is a member of the word-wide task force of vasculitic neuropathy and MGUS neuropathy. As president of the Dutch neuromuscular research organization (ISNO), she organized the 7th annual conference of the World Muscle Society in 2002, in Rotterdam. Since 2010, she is the director of the successful neuromuscular diseases residency program which attracts many residents from other teaching hospitals.
Research line
Polyneuropathy
Key publications
1: Warendorf JK, Vrancken AFJE, van Eijk RPA, Visser NA, van den Berg LH, Notermans NC. Statins do not increase risk of polyneuropathy: a case-control study and literature review. Neurology. 2019 Apr 30;92(18):e2136-e2144
2. Vos JM, Notermans NC, D'Sa S, Lunn MP, van der Pol WL, Kraan W, Reilly MM, Chalker J, Gupta R, Kersten MJ, Pals ST, Minnema MC. High prevalence of the MYD88 L265P mutation in IgM anti-MAG paraprotein-associated peripheral neuropathy. J Neurol Neurosurg Psychiatry. 2018 Sep;89(9):1007-1009
3. Pruppers MHJ, Merkies ISJ, Lunn MPT, Notermans NC; IMAGiNe Study Group. 230th ENMC International Workshop: Improving future assessment and research in IgM anti-MAG peripheral neuropathy: a consensus collaborative effort, Naarden, The Netherlands, 24-26 February 2017. Neuromuscul Disord. 2017 Nov;27(11):1065-1072
4: Visser NA, Vrancken AF, van der Schouw YT, van den Berg LH, Notermans NC. Chronic idiopathic axonal polyneuropathy is associated with the metabolic syndrome. Diabetes Care. 2013 36(4):817-22.
5: Niermeijer JM, Fischer K, Eurelings M, Franssen H, Wokke JH, Notermans NC. Prognosis of polyneuropathy due to IgM monoclonal gammopathy: a prospective cohort study. Neurology. 2010 2;74(5):406-12.
6: Niermeijer JM, Eurelings M, van der Linden MW, Lokhorst HM, Franssen H, Fischer K, Teunissen LL, van den Berg LH, Schobben F, Wokke JH, Notermans NC. Intermittent cyclophosphamide with prednisone versus placebo for polyneuropathy with IgM monoclonal gammopathy. Neurol. 2007 3;69(1):50-9.
7: Franssen H, Notermans NC. Length dependence in polyneuropathy associated with IgM gammopathy. Ann Neurol. 2006;59(2):365-71
Fellowship & awards
1: ENMC Grant, starten Europees samenwerkingsverband MGUS (2016)
2: Guillain-Barré Peripheral Nerve Society Grant: IgM Anti-MAG peripheral Neuropathy (Imagine study). From proper assessment to trial needs (2015)
3: Prinses Beatrix Foundation grant (2009-2014): Unraveling CIAP pathogenesis
4: NWO-AGIKO grant (2002-2007): Analysis chromosomal aberrations and risk factors MGUS
5: ZonMw Netwerk grant (2001)
6: ZonMw Health care efficiency research grant (1999-2002)
7: NWO- AGIKO grant (1996-2001): CIAP, the role of ischemia in pathogenesis
Education
Basic Teaching Qualification (2016)
