Profile photo Neeltje Steeghs

Neeltje Steeghs

Full Professor

Strategic program(s):

Biography

Neeltje Steeghs, M.D., Ph.D. is a licensed Medical Oncologist and Clinical Pharmacologist.  She served as chair of the Dutch Pharmacology Oncology Group and chair of the Dutch GIST consortium. Her main scientific interests are new drug development, including the  performance of clinical phase I and early phase II trials, and the inclusion of pharmacokinetics and pharmacodynamics in these studies. She also has a major interest in the design aspects of early clinical studies.
Besides her clinical activities, she has been Clinical Assessor for the Medicines Evaluation Board of the European Medicines Agency (2009-2011), chair of the Dutch Sarcoma Study Group, board member for the Paediatric Oncology Research Foundation (2010-2013), Young investigator for the EORTC Soft Tissue and Bone Sarcoma Group (2013-2016), chair of the multidisciplinary expert board for the Center for Personalized Cancer Treatment (2012-2015) and Vice-Chair of the Medical Ethical Committee of the Netherlands Cancer Institute. She has also been board member for the Dutch Oncological Medicine Evaluation Board, the National Working Party for Cancer Drugs Interactions and the Translational Research Board of the Netherlands Cancer Institute. She has a.o. been editor of Gastrointestinal Stromal Tumor (GIST), and Pharmacology of Anti-Cancer Drugs.
She currently serves as Director for the National Platform of Early Phase Clinical Trials at Oncode Accelerator/University Medical Center Utrecht, as Director of the Early Drug Development Center and Clinical Research at the Netherlands Cancer Institute, in Amsterdam, the Netherlands and as advisor for several pharmaceutical companies.
Neeltje Steeghs has been principle investigator for many investigator initiated and industry sponsored clinical trials. She is regarded as a leading authority on mechanisms for safe and effective dosing of anticancer agents. She has authored or co-authored over 200 scientific papers, and has given numerous lectures on a variety of topics at international meetings.
Neeltje Steeghs was invited to join the ESMO 2024 Scientific Committee as member of the Developmental therapeutics track.

Strategic program(s):

Contact

Recent publications

Multiparametric magnetic resonance imaging for radiotherapy response evaluation in high-risk soft tissue sarcoma Milan van Meekeren, Petra J van Houdt, Marta Fiocco, Jessica M Winfield, Christina Messiou, Birthe C Heeres, Hans Gelderblom, Neeltje Steeghs, Rick Haas, Kirsten van Langevelde
Physics and Imaging in Radiation Oncology, 2025, vol. 35
Targeting the DNA damage response to enhance radiotherapy in soft tissue sarcomas Bauke H G van Riet, Sanne Venneker, Judith V M G Bovée, Neeltje Steeghs, Rick L Haas
Critical Reviews in Oncology/Hematology, 2025, vol. 214
Imatinib Desensitization After a Type IV Hypersensitivity Reaction in a Gastrointestinal Stromal Tumor Patient-A Case Report Maud B A van der Kleij, Tristan V M Bruijn, Raween W Kalicharan, Yannick S Elshot, Maxime C F Pilon, Mark Oostdijk, Matthijs M Tibben, Bastiaan Nuijen, Alwin D R Huitema, Thomas Rustemeyer, Neeltje Steeghs
Cancer reports (Hoboken, N.J.), 2025, vol. 8
The role of whole-genome sequencing for guiding systemic therapy in patients with soft tissue sarcoma P van der Laan, W J van Houdt, H van Boven, P Snaebjornsson, L J W Bosch, K Monkhorst, Y M Schrage, L Heimans, J M Kerst, N Steeghs, W T A van der Graaf
ESMO open, 2025, vol. 10
Phase II study of elraglusib (9-ING-41), a GSK-3β inhibitor, in combination with gemcitabine plus nab-paclitaxel in previously untreated metastatic pancreatic cancer D Mahalingam, A Saeed, S F Powell, M Huerta, V Sahai, A L Coveler, E J Davis, N Steeghs, M Mulcahy, A G Raufi, L Cavalcante, A Cervantes, J Berlin, T Weisskittel, A Ugolkov, A P Mazar, W Mikrut, S Smith, F J Giles, B A Carneiro
ESMO open, 2025, vol. 10
Phase I Study of Sorafenib Combined with Gemcitabine and Carboplatin in Patients with Advanced Solid Tumors Daphne W M Voogd, Merel J J Lucassen, Ruud van der Noll, Sybrand W J Zielhuis, David Boss, Jos H Beijnen, Hilde Rosing, Matthijs Tibben, Alwin D R Huitema, Jan H M Schellens, Neeltje Steeghs
Oncology and therapy, 2025, vol. 13, p.465-483

External positions

lid portfolio review board - 1x per 2 jaar portfolio review - Cancer Research UK Center for Drug Development

Internist-oncoloog/hoofd CRU - Internist-oncoloog/hoofd CRU - Nederlands Kanker Instituut - Antoni van Leeuwenhoek

editor - editor - Journals (meerdere)

Consultancy - Advisering tav medicijn ontwikkeling en klinische studies - Meerdere farmaceutische bedrijven

Lid - Beoordeling studievoorstellen - METC