Profile photo Monique Minnema

Monique Minnema

Full Professor

Strategic program(s):

Biography

Prof Dr Monique Minnema was trained as internist and hematologist at Academic Medical Center, Amsterdam and the University Medical Center, Utrecht. She started working as a hematologist in 2005 at the department of hematology, UMC Utrecht and was appointed full professor in 2019. She is specialized in the diagnosis and treatment of B cell malignancies, especially plasma cell dyscrasis like Multiple Myeloma, AL amyloidosis, and Waldenstrom Macroglobulinemia. Prof Minnema is author on several national and internatonial quidelines on the diagnosis and treatment of these diseases.
She is head supervisor of the hematology clinical research team, the hematology biobank and the European expertise reference network (ERN) malignant hematology of the UMC Utrecht. Her main focus of clinical research is the development of novel therapies (both cellular and drug) for plasma cell dyscrasias and the development of new research structures for hematology research in the Netherlands.

Prof Dr Minnema is vice chairperson of the HOVON working partie for Multiple
Myeloma, and member of the Lymphoma and IEC working parties. Examples of her work are the HOVON 104 trial and the use of the monoclonal antibody Daratumumab for patients with AL amyloidosis in first line treatment, the clinical studies with Daratumumab and the bispecific antibody Talquetamab in relapsed Multiple Myeloma the use of anti CD19 CAR T cells in relapsed Lymphoma.
Her translational research focuses on 3D models to predict response to therapy and the use of combined immunotherapy for relapsed multiple myeloma.

She was a member of the organizing committee of the Waldenström workshop in Amsterdam in 2016, and is co initiator of the yearly Immune Effector Cell Symposium and the current chair of the Systemic Amyloidosis symposium in the Netherlands

Research groups

B cell malignancies

Research aim

Our research aim is to control cellular life and death decisions to improve treatment of B cell cancers and allow T cell immunotherapy for untreatable cancers.

Go to group

Decision support systems for precision care in translational cancer-imaging

Research aim

To develop, validate and implement decision support systems based on imaging for the diagnosis, prognosis and triaging of oncology patients

Go to group

Recent publications

Uncovering cell type-specific phenotypes using a novel human in vitro model of transthyretin amyloid cardiomyopathy Jiabin Qin, Qiangbing Yang, Asier Ullate-Agote, Vasco Sampaio-Pinto, Laura Florit, Inge Dokter, Chrysoula Mathioudaki, Lotte Middelberg, Pilar Montero-Calle, Paula Aguirre-Ruiz, Joana de Las Heras Rojo, Zhiyong Lei, Zeping Qiu, Jin Wei, Pim van der Harst, Felipe Prosper, Manuel M Mazo, Olalla Iglesias-García, Monique C Minnema, Joost P G Sluijter, Marish I F J Oerlemans, Alain van Mil
Stem cell research & therapy, 2025, vol. 16
Report of consensus panel 2 from the 12th international workshop on the management of Bing-Neel syndrome in patients with Waldenstrom's Macroglobulinemia Shayna Sarosiek, Anne-Marie L Becking, Andrew Branagan, Simone Ferrero, Jahanzaib Khwaja, Eva Kimby, Damien Roos-Weil, Naohiro Sekiguchi, Marek Trneny, Shuhua Yi, Christopher J Patterson, Christian Buske, Jeffrey V Matous, Steven P Treon, Monique C Minnema
Seminars in Hematology, 2025, vol. 62, p.85-89
Engineering anti-BCMA CAR T cells for enhancing myeloma killing efficacy via apoptosis regulation Thomas Kimman, Marta Cuenca, Ralph G Tieland, Dedeke Rockx-Brouwer, Jasmijn Janssen, Benjamin Motais, Anne Slomp, Corine Pleijte, Sabine Heijhuurs, Angelo D Meringa, Wendy Boschloo, Douwe Mt Bosma, Sanne Kroos, Vania Lo Presti, Joost P G Sluijter, Stefan Nierkens, Niels Bovenschen, Jürgen Kuball, Alain van Mil, Monique C Minnema, Zsolt Sebestyén, Victor Peperzak
Nature Communications, 2025, vol. 16
Report of Consensus Panel 5 from the 12th International Workshop on Waldenstrom's Macroglobulinemia on the management of patients with intolerance or resistance to covalent BTK inhibitors Jorge J Castillo, Francesco Autore, Neil L Berinstein, Andrew R Branagan, Meletios A Dimopoulos, Carlos Fernandez de Larrea, Simone Ferrero, Prashant Kapoor, Efstathios Kastritis, Jahanzaib Khwaja, Monique C Minnema, Lugui Qiu, John F Seymour, Josephine M I Vos, Christopher J Patterson, Christian Buske, Jeffrey V Matous, Steven P Treon, M Lia Palomba
Seminars in Hematology, 2025, vol. 62, p.113-119
Automated vertebrae identification and segmentation with structural uncertainty analysis in longitudinal CT scans of patients with multiple myeloma Djennifer K Madzia-Madzou, Margot Jak, Bart de Keizer, Jorrit-Jan Verlaan, Monique C Minnema, Kenneth Gilhuijs
European Journal of Radiology, 2025, vol. 188
Zanubrutinib in Bing Neel syndrome Anne-Marie L Becking, Johannes P M van de Mortel, Oliver Tomkins, Thijs W H Flinsenberg, Nicole Japzon, Marie José Kersten, Jahanzaib Khwaja, Saskia Kuipers, Henriette Levenga, Sean McKeague, Stephen Opat, Ross T Salvaris, Sherif Seif, Sheeba K Thomas, Alexander F J E Vrancken, Shirley D'Sa, Monique C Minnema, Josephine M I Vos
Leukemia, 2025, vol. 39, p.1260–1264

External positions

Data Monitoring Committee for Galapagos’ ongoing hematological clinical trial programs - voorzitter - Galapagos

Myeloom Werkgroep - Vice voorzitter - HOVON

Commissie Dataregistratie en Cohorten - voorzitter - HOVON

voorzitter - Myeloom Werkgroep commissie CART - HOVON

Commissie Wetenschap en Onderzoek - voorzitter - NVvH

European Consortium for Waldenstrom’s Macroglobulinemia - lid - ECWM

International Myeloma Working Group - lid - IMWG

EXCALIBER Data Monitoring Committee - lid - BMS

Aquarius Steering Committee - lid - Janssen

Scientific Advisory Sub-Committee on the WM Global Awareness Building Initiative - lid - IWMF

Medical Advisory Committee - lid - MPE

Beoordelingscommissie Ontwikkeling en Implementatie - lid - KWF

Algemeen bestuur - lid - NVvH

Lymfoom Werkgroep - Lid - HOVON

Immune Effector Cell werkgroep - Lid - HOVON