Profile photo Monique Minnema

Monique Minnema

Full Professor

Strategic program(s):

Biography

Prof Dr Monique Minnema was trained as internist and hematologist at Academic Medical Center, Amsterdam and the University Medical Center, Utrecht. She started working as a hematologist in 2005 at the department of hematology, UMC Utrecht and was appointed full professor in 2019. She is specialized in the diagnosis and treatment of B cell malignancies, especially plasma cell dyscrasis like Multiple Myeloma, AL amyloidosis, and Waldenstrom Macroglobulinemia. Prof Minnema is author on several national and internatonial quidelines on the diagnosis and treatment of these diseases.
She is head supervisor of the hematology clinical research team, the hematology biobank and the European expertise reference network (ERN) malignant hematology of the UMC Utrecht. Her main focus of clinical research is the development of novel therapies (both cellular and drug) for plasma cell dyscrasias and the development of new research structures for hematology research in the Netherlands.

Prof Dr Minnema is vice chairperson of the HOVON working partie for Multiple
Myeloma, and member of the Lymphoma and IEC working parties. Examples of her work are the HOVON 104 trial and the use of the monoclonal antibody Daratumumab for patients with AL amyloidosis in first line treatment, the clinical studies with Daratumumab and the bispecific antibody Talquetamab in relapsed Multiple Myeloma the use of anti CD19 CAR T cells in relapsed Lymphoma.
Her translational research focuses on 3D models to predict response to therapy and the use of combined immunotherapy for relapsed multiple myeloma.

She was a member of the organizing committee of the Waldenström workshop in Amsterdam in 2016, and is co initiator of the yearly Immune Effector Cell Symposium and the current chair of the Systemic Amyloidosis symposium in the Netherlands

Research groups

B cell malignancies

Research aim

Our research aim is to control cellular life and death decisions to improve treatment of B cell cancers and allow T cell immunotherapy for untreatable cancers.
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Decision support systems for precision care in translational cancer-imaging

Research aim

To develop, validate and implement decision support systems based on imaging for the diagnosis, prognosis and triaging of oncology patients
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Recent publications

Healthcare Resource Utilization and Cost-of-Illness in Systemic Light Chain (AL) Amyloidosis in Europe Arnaud Jaccard, Frank Bridoux, Wilfried Roeloffzen, Monique C Minnema, Rui Bergantim, Roman Hájek, Cristina João, M Teresa Cibeira, Giovanni Palladini, Stefan Schönland, Giampaolo Merlini, Paolo Milani, Meletios A Dimopoulos, Sriram Ravichandran, Ute Hegenbart, Hermine Agis, Blanca Gros, Aisha Asra, Valeria Magarotto, Giorgos Cheliotis, Giorgos Psarros, Pieter Sonneveld, Ashutosh Wechalekar, Efstathios Kastritis
Clinical Lymphoma, Myeloma and Leukemia, 2024, vol. 24, p.e205-e216
Identifying clinical response to daratumumab therapy in relapsed/refractory multiple myeloma using a patient-derived in vitro model Niels van Nieuwenhuijzen, Marta Cuenca, Leonie Abbink, Margot Jak, Victor Peperzak, Monique C Minnema
EJHaem, 2024, vol. 5, p.141-146
Impact of debulking therapy on the clinical outcomes of axicabtagene ciloleucel in the treatment of relapsed or refractory large B-cell lymphoma Tom van Meerten, John Kuruvilla, Kevin W Song, Catherine Thieblemont, Monique C Minnema, Edouard Forcade, Sophie De Guibert, Marie José Kersten, Pim Gnj Mutsaers, Martin Wermke, Yan Zheng, Allen Xue, Joshua N Winters, Jenny Nater, Rhine R Shen, Clare Spooner, Frank Neumann, Jenny J Kim, Max S Topp
American Journal of Cancer Research [E], 2024, vol. 14, p.2905-2920
Bispecific Antibody Use in Patients With Lymphoma and Multiple Myeloma Adam Braun, Sushanth Gouni, Astrid Pulles, Paolo Strati, Monique C Minnema, Lihua E Budde
American Society of Clinical Oncology educational book , 2024, vol. 44
HOVON 104, long-term follow-up of bortezomib-dexamethasone induction therapy followed by autologous stem cell transplantation in newly diagnosed AL amyloidosis patients Monique C Minnema, Kazem Nasserinejad, Ute Hegenbart, Paula F Ypma, Ka Lung Wu, Marie Jose Kersten, Sandra Croockewit, Sonja Zweegman, Lidwine Tick, Annemiek Broijl, Harry Koene, Gerard M J Bos, Pieter Sonneveld, Stefan O Schönland
EJHaem, 2024, vol. 5, p.815-819
Primary cerebral immunoglobulin light chain amyloidoma in a patient with multiple sclerosis Marissa J M Traets, Krisna Chuwonpad, Roos J Leguit, Stephan T F M Frequin, Monique C Minnema
BMJ Case Reports, 2024, vol. 17

Fellowships & Awards

2017: Dutch Cancer Society/KWF Research Project: Personalized strategy to avert drug resistance in hematologic cancers.